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Application value of DCE-MRI in tumor body, peritumoral edema area in grading diffuse glioma
WANG Ru  WANG Shaoyu  ZHANG Huapeng  GAO Yang 

Cite this article as: Wang R, Wang SY, Zhang HP, et al. Application value of DCE-MRI in tumor body, peritumoral edema area in grading diffuse glioma[J]. Chin J Magn Reson Imaging, 2021, 12(6): 88-91. DOI:10.12015/issn.1674-8034.2021.06.017.


[Abstract] Objective To investigate the perfusion characteristics of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) in tumor body and peritumoral edema of patients with diffuse glioma and its clinical value in grading glioma, so as to provide a reliable surgical resection range. Materials andMethods According to the 2016 WHO glioma classification and grading criteria, patients were divided into low-grade glioma group (LGG group, Ⅱ grade) 17 cases and high-grade glioma group (HGG group, Ⅲ+Ⅳ grade) 27 cases. All patients underwent DCE-MRI before operation. The workstation performed DCE-MRI post-processing, and extracted two parameters: volume translocation constant (Ktrans) and extravascular extracellular space volume fraction (Ve). The tumor area, extra-tumor edema 1 cm, extra-tumor edema 1—2 cm area and contralateral hemisphere normal white area were the regions of interest, then measured the values of each parameter and analyzed the differences in high and low-grade gliomas. Spearman correlation coefficient was used to analyze the correlation between the parameters and pathological grade of diffuse glioma.Results The Ktrans and Ve in the tumor area and extratumoral edema of the HGG group were higher than those in the LGG group (Ktrans value compared, t=7.821, 9.468, 8.670, Ve value compared, t=4.411, 7.812, 2.544; P＜0.05). The Ktrans and Ve of two groups in every region were decreasing from tumor area to normal white matter area. In the two groups, there was a statistically significant difference between the tumor area and the extra-tumor edema 1 cm, extra-tumor edema 1—2 cm area and the normal white matter area (HGG group: Ktrans value compared, t=5.845, 9.907, 10.654, Ve value compared, t=4.398, 8.194, 9.014; P＜0.05; LGG group: Ktrans value compared, t=7.763, 8.085, 8.397, Ve value compared, t=6.719, 7.328, 7.370; P＜0.05). In the HGG group, there was a statistically significant difference between the extra-tumor edema 1 cm and the extra-tumor edema 1—2 cm area, normal white matter area (Ktrans value compared, t=6.966, 7.780, Ve value compared, t=7.920, 8.053; P＜0.05), there was no significant difference between the extra-tumor edema 1—2 cm area and the normal white matte area (Ktrans value compared, t=1.006, Ve value compared, t=0.617; P＞0.05); in the LGG group, there was no statistically significant difference between the extra-tumor edema 1 cm area and the extra-tumor edema 1—2 cm area (Ktrans value compared, t=1.733, Ve value compared, t=1.751; P＞0.05), between the extra-tumor edema 1 cm area and the normal white matter area (Ktrans value compared, t=2.012, Ve value compared, t=2.021; P＞0.05), between the extra-tumor edema 1—2 cm area and the normal white matter area (Ktrans value compared, t=0.654, Ve value compared, t=1.184; P＞0.05). Ktrans value and Ve value were positively correlated with pathological grade of diffuse glioma (r=0.811, 0.734, P＜0.05).Conclusions DCE-MRI can improve the grade of tumor and guide the scope of clinical resection.
[Keywords] diffuse glioma；peritumoral edema；dynamic contrast enhanced；magnetic resonance imaging；grading；perfusion imaging

WANG Ru1   WANG Shaoyu2   ZHANG Huapeng2   GAO Yang1*  

1 Affiliated Hospital of Inner Mongolia Medical University, Hohhot 010050, China

2 SIEMENS Healthineers, Shanghai 201318, China

Gao Y, E-mail: 1390903990@qq.com

Conflicts of interest   None.

This work was part of Science and Technology Project of Inner Mongolia Autonomous Region (No. 2019GG047).
Received  2020-12-13
Accepted  2021-02-25
DOI: 10.12015/issn.1674-8034.2021.06.017
Cite this article as: Wang R, Wang SY, Zhang HP, et al. Application value of DCE-MRI in tumor body, peritumoral edema area in grading diffuse glioma[J]. Chin J Magn Reson Imaging, 2021, 12(6): 88-91. DOI:10.12015/issn.1674-8034.2021.06.017.

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