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Predictive effect of Gd-EOB-DTPA enhanced MRI for HBV-related diameter ≤ 1 cm sHCC intrahepatic metastasis
LI Xueqin  PAN Ziang  WANG Xing  ZHAO Dawei  LIN Dongdong  YANG Guang  LIU Hui  REN Meiji  XIA Zhenying  LI Hongjun  LI Dechun 

Cite this article as: Li XQ, Pan ZA, Wang X, et al. Predictive effect of Gd-EOB-DTPA enhanced MRI for HBV-related diameter ≤1 cm sHCC intrahepatic metastasis[J]. Chin J Magn Reson Imaging, 2021, 12(6): 97-101. DOI:10.12015/issn.1674-8034.2021.06.019.


[Abstract] Objective To explore the predictive effect of Gd-EOB-DTPA (Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid, Gd-EOB-DTPA) enhanced MRI for metastasis of hepatocellular carcinoma (HCC) with diameter ≤1 cm. Materials andMethods Forty-five patients (median age 55 years old, male 71.1%) without intrahepatic metastasis, without tumor embolus in portal vein trunk and primary branch, with sufficient incisal margin and diameter of ≤1 cm were followed up for a median time of 13 months, and were divided into metastatic group (n=15) and non-metastatic group (n=30) according to whether HCC intrahepatic metastasis occurred. Clinical and imaging characteristics between two groups were compared and risk factors of HCC intrahepatic metastasis were determined by univariate Kaplan-Meier analysis and multivariate Cox regression.Results Compared with the non-metastatic group, HCC with intrahepatic metastasis in the early stage of Gd-EOB-DTPA enhanced MRI images was likely to show hypointensity on T1WI (9/60.0%, P=0.042), hyperintensity on DWI (12/80.0%, P＜0.001), homogeneous enhancement in the arterial phase (10/66.7% P=0.017), hypointensity in transitional (12/80.0%, P=0.001) and hepatobiliary phase (9/60.0%, P=0.016); minimal signal ＞1/2 in hepatobiliary phase (14/93.3%,P＜0.001). After adjusting for age, sex, differentiation grade, Edmondson grade in the multivariate Cox model, hypointensity in transitional phase (HR=6.19, 95% CI: 1.73—22.16, P=0.005) was independent risk factor for HCC intrahepatic metastasis.Conclusions Gd-EOB-DTPA enhanced MRI has advantages in predicting intrahepatic metastasis of HCC lesions with a diameter ≤1 cm. It can provide support for the formulation of therapeutic regimen as soon as possible.
[Keywords] Gd-EOB-DTPA；magnetic resonance imaging；hepatocellular carcinoma；intrahepatic metastasis

LI Xueqin1   PAN Ziang2   WANG Xing1   ZHAO Dawei1   LIN Dongdong1   YANG Guang1   LIU Hui1   REN Meiji1   XIA Zhenying1   LI Hongjun1   LI Dechun3*  

1 Youan Hospital Affiliated of Capital Medical University, Beijing 100069, China

2 Peking Union Medical College & Chinese Academy of Medical Sciences, Peking Union Medical College Hospital, Beijing 100730, China

3 Xuzhou Central Hospital, Xuzhou 221009, China

Li DC, E-mail: 18952171358@189.cn

Conflicts of interest   None.

Received  2021-02-04
Accepted  2021-03-29
DOI: 10.12015/issn.1674-8034.2021.06.019
Cite this article as: Li XQ, Pan ZA, Wang X, et al. Predictive effect of Gd-EOB-DTPA enhanced MRI for HBV-related diameter ≤1 cm sHCC intrahepatic metastasis[J]. Chin J Magn Reson Imaging, 2021, 12(6): 97-101. DOI:10.12015/issn.1674-8034.2021.06.019.

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