Share：
Share this content in WeChat
X
[Chinese][PDF]149892
• Clinical Article •
An explorative resting-state fMRI study of central mechanism in patients with primary dysmenorrhea during menstrual phase by using the method of degree centrality
LIU Ni  ZHANG Ya'nan  WU Junchen  HAO Ying  LI Wenxun  XIA Jing  LIU Zhidan  LI Yingqiu  HUANG Yiran  HUO Jianwei 

Cite this article as: Liu N, Zhang YN, Wu JC, et al. An explorative resting-state fMRI study of central mechanism in patients with primary dysmenorrhea during menstrual phase by using the method of degree centrality[J]. Chin J Magn Reson Imaging, 2021, 12(7): 29-33. DOI:10.12015/issn.1674-8034.2021.07.006.


[Abstract] Objective To investigate the central mechanism during menstrual phase in patients with primary dysmenorrhea (PDM) by using the method of degree centrality (DC) based on resting-state functional magnetic resonance imaging (rs-fMRI). Materials andMethods Thirty-five patients (PDM group) and forty-one healthy women (HC group) were recruited for the study. The clinical data of two groups was performed, including Visual Analogue Scale for Pain and Anxiety, accompanying Symptom Score of Dysmenorrhea. Meanwhile, rs-fMRI data were collected. The difference of DC values between the two groups and the correlation between DC values in different brain regions and clinical data were analyzed by using DPABI software.Results Compared to the healthy controls, patients with PDM demonstrated significantly increased DC values in the bilateral middle frontal gyrus, left orbital superior frontal gyrus and precuneus, and decreased values in the left brainstem, superior and middle temporal gyrus (Gaussian random field corrected, voxel P＜0.001, cluster P＜0.05, two tailed). The DC value of the right middle frontal gyrus was negatively correlated with the course of disease (r=0.383, P=0.023).Conclusions Among the central mechanisms during menstrual phase in PDM patients, the prefrontal region may be involved in the compensatory brain activity in response to cognitive regulation of pain,, while the precuneus may be involved in the central pain sensitization mechanism. The cerebellum and brainstem may also be involved in pain-related processing.
[Keywords] primary dysmenorrhea；menstruation；resting-state functional magnetic resonance imaging；degree centrality；brain network

LIU Ni1   ZHANG Ya'nan1   WU Junchen1   HAO Ying2   LI Wenxun3   XIA Jing3   LIU Zhidan3   LI Yingqiu3   HUANG Yiran3*   HUO Jianwei1*  

1 Department of Radiology, Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing 100010, China

2 Beijing International Center for Mathematical Research, Peking University, Beijing 100871, China

3 School of Acupuncture Moxibustion & Tuina, Beijing University of Chinese Medicine, Beijing 100029, China

Huo JW, E-mail: huojianwei@bjzhongyi.com Huang YR, E-mail: caicai13@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS This article is supported by the National Natural Science Foundation of China (No. 81503652).
Received  2021-02-24
Accepted  2021-04-06
DOI: 10.12015/issn.1674-8034.2021.07.006
Cite this article as: Liu N, Zhang YN, Wu JC, et al. An explorative resting-state fMRI study of central mechanism in patients with primary dysmenorrhea during menstrual phase by using the method of degree centrality[J]. Chin J Magn Reson Imaging, 2021, 12(7): 29-33. DOI:10.12015/issn.1674-8034.2021.07.006.

1
Iacovides S, Avidon I, Baker F. What we know about primary dysmenorrhea today: a critical review[J]. Hum Reprod Update, 2015, 21(6): 762-778. DOI: 10.1093/humupd/dmv039.
2
Iacovides S, Baker F, Avidon I, Bentley A. Women with dysmenorrhea are hypersensitive to experimental deep muscle pain across the menstrual cycle[J]. J Pain, 2013, 14(10): 1066-1076. DOI: 10.1016/j.jpain.2013.04.010.
3
Nloh A, Ngadjui E, Vogue N, et al. Prevalence and factors associated with dysmenorrhea in women at child bearing age in the Dschang health district, west-cameroon[J]. Pan Afr Med J, 2020, 37: 178. DOI: 10.11604/pamj.2020.37.178.19693.
4
Ortiz M. Primary dysmenorrhea among Mexican university students: prevalence, impact and treatment[J]. Eur J Obstet Gynecol Reprod Biol, 2010, 152(1): 73-77. DOI: 10.1016/j.ejogrb.2010.04.015.
5
Ortiz M, Rangel-Flores E, Carrillo-Alarcón L, et al. Prevalence and impact of primary dysmenorrhea among Mexican high school students[J]. Int J Gynaecol Obstet, 2009, 107(3): 240-243. DOI: 10.1016/j.ijgo.2009.07.031.
6
Dawood M. Primary dysmenorrhea: advances in pathogenesis and management[J]. Obstet Gynecol, 2006, 108(2): 428-441. DOI: 10.1097/01.AOG.0000230214.26638.0c.
7
Burnett M, Lemyre M. No. 345-Primary Dysmenorrhea Consensus Guideline[J]. J Obstet Gynaecol Can, 2017, 39(7): 585-595. DOI: 10.1016/j.jogc.2016.12.023.
8
Zahradnik H, Hanjalic-Beck A, Groth K. Nonsteroidal anti-inflammatory drugs and hormonal contraceptives for pain relief from dysmenorrhea: a review[J]. Contraception, 2010, 81(3): 185-196. DOI: 10.1016/j.contraception.2009.09.014.
9
Liu P, Liu Y, Wang G, et al. Changes of functional connectivity of the anterior cingulate cortex in women with primary dysmenorrhea[J]. Brain Imaging Behav, 2018, 12(3): 710-717. DOI: 10.1007/s11682-017-9730-y.
10
Lisofsky N, Mårtensson J, Eckert A, et al. Hippocampal volume and functional connectivity changes during the female menstrual cycle[J]. Neuroimage. 2015, 118: 154-162. DOI: 10.1016/j.neuroimage.2015.06.012.
11
Wei S, Chao H, Tu C, et al. Changes in functional connectivity of pain modulatory systems in women with primary dysmenorrhea[J]. Pain, 2016, 157(1): 92-102. DOI: 10.1097/j.pain.0000000000000340.
12
Liao X, Xia M, Xu T, et al. Functional brain hubs and their test-retest reliability: a multiband resting-state functional MRI study[J]. Neuroimage, 2013, 83: 969-982. DOI: 10.1016/j.neuroimage.2013.07.058.
13
Guylaine L, Odette P, Viola A, et al. Primary dysmenorrhea consensus guideline[J]. J Obstet Gynaecol Can, 2005, 27(12): 1117-1146. DOI: 10.1016/s1701-2163(16)30395-4.
14
Zhang Q, Yu S, Wang Y, et al. Abnormal reward system network in primary dysmenorrhea[J]. Mol Pain, 2019, 15: 1744806919862096. DOI: 10.1177/1744806919862096.
15
Yang L, Dun W, Li K, et al. Altered amygdalar volume and functional connectivity in primary dysmenorrhoea during the menstrual cycle[J]. Eur J Pain, 2019, 23(5): 994-1005. DOI: 10.1002/ejp.1368.
16
Han F, Liu H, Wang K, et al. Correlation between thalamus-related functional connectivity and serum BDNF levels during the periovulatory phase of primary dysmenorrhea[J]. Front Human Neurosci, 2019, 13: 333. DOI: 10.3389/fnhum.2019.00333.
17
Liu P, Yang J, Wang G, et al. Altered regional cortical thickness and subcortical volume in women with primary dysmenorrhoea[J]. Eur J Pain, 2016, 20(4): 512-520. DOI: 10.1002/ejp.753.
18
Chen T, Mu J, Xue Q, et al. Whole-brain structural magnetic resonance imaging-based classification of primary dysmenorrhea in pain-free phase: a machine learning study[J]. Pain, 2019, 160(3): 734-741. DOI: 10.1097/j.pain.0000000000001428.
19
Lee L, Chen Y, Lin C, et al. Unaltered intrinsic functional brain architecture in young women with primary dysmenorrhea[J]. Sci Rep, 2018, 8(1): 12971. DOI: 10.1038/s41598-018-30827-6.
20
Jin L, Yang X, Liu P, et al. Dynamic abnormalities of spontaneous brain activity in women with primary dysmenorrhea[J]. J Pain Res, 2017, 10: 699-707. DOI: 10.2147/jpr.S121286.
21
Liu P, Liu Y, Wang G, et al. Aberrant default mode network in patients with primary dysmenorrhea: a fMRI study[J]. Brain Imaging Behav, 2017, 11(5): 1479-1485. DOI: 10.1007/s11682-016-9627-1.
22
Schwedt T. Structural and functional brain alterations in post-traumatic headache attributed to mild traumatic brain injury: a narrative review[J]. Front Neurol, 2019, 10: 615. DOI: 10.3389/fneur.2019.00615.
23
Schwedt T, Chong C, Peplinski J, et al. Persistent post-traumatic headache vs. migraine: an MRI study demonstrating differences in brain structure[J]. J Headache Pain, 2017, 18(1): 87. DOI: 10.1186/s10194-017-0796-0.
24
Yang F, Chou K, Fuh J, et al. Altered hypothalamic functional connectivity in cluster headache: a longitudinal resting-state functional MRI study[J]. J Neurol Neurosur Psychiatry, 2015, 86(4): 437-445. DOI: 10.1136/jnnp-2014-308122.
25
Lu L, Li F, Wang P, et al. Altered hypothalamic functional connectivity in post-traumatic headache after mild traumatic brain injury[J]. J Headache pain, 2020, 21(1): 93. DOI: 10.1186/s10194-020-01164-9.
26
Zyloney C, Jensen K, Polich G, et al. Imaging the functional connectivity of the periaqueductal gray during genuine and sham electroacupuncture treatment[J]. Mol, pain, 2010, 6: 80. DOI: 10.1186/1744-8069-6-80.
27
Zhang Y, Huang Y, Liu J, et al. Aberrant resting-state cerebral blood flow and its connectivity in primary dysmenorrhea on arterial spin labeling MRI[J]. Magn Reson Imaging, 2020, 73: 84-90. DOI: 10.1016/j.mri.2020.07.012.
28
Gong P, Zhang MM, Wang Q, et al. Effect of acupuncture at Sanyinjiao (SP6) on glucose metabolism in the patient of dysmenorrhea[J]. Zhongguo Zhen Jiu, 2006, 26(1): 51-55.
29
Claassen J, Labrenz F, Ernst T, et al. Altered cerebellar activity in visceral pain-related fear conditioning in irritable bowel syndrome[J]. Cerebellum, 2017, 16(2): 508-517. DOI: 10.1007/s12311-016-0832-7.
30
Habas C, Kamdar N, Nguyen D, et al. Distinct cerebellar contributions to intrinsic connectivity networks[J]. J Neurosci, 2009, 29(26): 8586-8594. DOI: 10.1523/jneurosci.1868-09.2009.
31
Seifert F, Maihöfner C. Representation of cold allodynia in the human brain--a functional MRI study[J]. Neuroimage, 2007, 35(3): 1168-1180. DOI: 10.1016/j.neuroimage.2007.01.021.
32
Kutch J, Tu F. Altered brain connectivity in dysmenorrhea: pain modulation and the motor cortex[J]. Pain, 2016, 157(1): 5-6. DOI: 10.1097/j.pain.0000000000000364.
33
Zhang Y, Huo J, Huang Y, et al. Altered amplitude of low-frequency fluctuation and regional cerebral blood flow in females with primary dysmenorrhea: a resting-state fMRI and arterial spin labeling study[J]. J Pain Res, 2019, 12: 1243-1250. DOI: 10.2147/jpr.S177502.
34
Lee P, Low I, Chen Y, et al. Encoding of menstrual pain experience with theta oscillations in women with primary dysmenorrhea[J]. Sci Rep, 2017, 7(1): 15977. DOI: 10.1038/s41598-017-16039-4.
35
Ozgocer T, Ucar C, Yildiz S. Cortisol awakening response is blunted and pain perception is increased during menses in cyclic women[J]. Psychoneuroendocrinology, 2017, 77: 158-164. DOI: 10.1016/j.psyneuen.2016.12.011.

PREV Comparation of amide proton transfer-weighted and T2 mapping in quantifying rectal cancer with and without chemotherapy: a preliminary study
NEXT The value of T2 mapping texture features of 3.0 T MRI in grading cartilage injury of knee osteoarthritis
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn