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• Original Article •
Analysis of corticospinal tract injury in stroke based on a corticospinal tract template derived from healthy subjects
WEI Yu  YU Qiurong  YIN Dazhi  WANG Hewei  SUN Limin  XU Guojun  ZHAN Shuang  WANG Xuefei  GUO Miao  LIU Fan  FAN Mingxia 

Cite this article as: Wei Y, Yu QR, Yin DZ, et al. Analysis of corticospinal tract injury in stroke based on a corticospinal tract template derived from healthy subjects[J]. Chin J Magn Reson Imaging, 2021, 12(7): 39-44, 68. DOI:10.12015/issn.1674-8034.2021.07.008.


[Abstract] Objective To explore the relationship between diffusion parameters of corticospinal tract (CST) and motor dysfunction in stroke using diffusion tensor imaging (DTI). Materials andMethods DTI data were collected from 37 unilateral subcortical stroke patients and 30 healthy subjects (HCs). A CST template was generated from the CST of HCs which was tracked by using the probabilistic tractography. Based on the template, the diffusion parameters of fractional anisotropy (FA) and mean diffusivity (MD) were measured , further, the FA ratio (rFA), FA asymmetry (FAasy), MD ratio (rMD) and MD asymmetry (MDasy) were calculated to assess the CST impairments in stroke patients. Furthermore, the correlations of these CST diffusion parameters with Fugl-Meyer Assessment (FMA) were performed.Results Compared with HCs, FA of the ipsilesional CST and rFA decreased significantly (t=-15.775, t=-11.111, P＜0.001, respectively) while FAasy increased significantly (t=9.473, P＜0.001); MD of the ipsilesional CST and rMD increased significantly (t=9.553, t=7.733, P＜0.001, respectively) while MDasy decreased significantly (t=-8.941, P＜0.001); no significant differences of these diffusion parameters were observed in the contralesional CST (P＞0.05). Neither disease duration nor lesion size was significantly correlated with these diffusion parameters (P＞0.05). FA of the ipsilesional CST and rFA was positively correlated with "hand+wrist" and upper limb FMA (r=0.342, P=0.038; r=0.479, P=0.003; r=0.343, P=0.038; r=0.482, P=0.003, respectively), while FAasy was negatively correlated with "hand+wrist" and upper limb FMA (r=-0.353, P=0.032; r=-0.490, P=0.002, respectively). In addition, stepwise regression analysis revealed that the correlations between FAasy and "hand+wrist" and upper limb FMA was stronger than that with FA of the ipsilesional CST and rFA (Beta=-0.353, P=0.032; Beta=-0.490, P=0.002, respectively).Conclusions FA parameters derived from CST template may reflect CST microstructural integrity impairments following stroke. FAasy was closely related to the "hand+wrist" and upper limb FMA implying an important reference index for assessing motor dysfunction of the upper limbs and "hand+wrist" in stroke patients.
[Keywords] magnetic resonance imaging；diffusion tensor imaging；stroke；corticospinal tract；motor dysfunction

WEI Yu1   YU Qiurong1   YIN Dazhi2   WANG Hewei3   SUN Limin3   XU Guojun1   ZHAN Shuang1   WANG Xuefei1   GUO Miao1   LIU Fan1   FAN Mingxia1*  

1 Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

2 School of Psychology and Cognitive science, East China Normal University, Shanghai 200062, China

3 Huashan Hospital, Fudan University, Shanghai 200040, China

Fan MX, E-mail: mxfan@phy.ecnu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS This work was supported by the National Natural Science Foundation of China (No. 81471651), the National Natural Science Foundation of China (No. 81974356), the Young National Natural Science Foundation of China (No. 81401859), the National Key R&D Program of China (No.2020YFC2004200).
Received  2021-04-28
Accepted  2021-05-27
DOI: 10.12015/issn.1674-8034.2021.07.008
Cite this article as: Wei Y, Yu QR, Yin DZ, et al. Analysis of corticospinal tract injury in stroke based on a corticospinal tract template derived from healthy subjects[J]. Chin J Magn Reson Imaging, 2021, 12(7): 39-44, 68. DOI:10.12015/issn.1674-8034.2021.07.008.

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