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• Original Article •
Study of whole-liver histogram analysis based on Gd-EOB-DTPA hepatobiliary phase for evaluating liver fibrosis in rabbits
LI Yufeng  LIU Haifeng  WANG Qing  DU Ya'nan  ZHU Zuhui  XING Wei 

Cite this article as: Li YF, Liu HF, Wang Q, et al. Study of whole-liver histogram analysis based on Gd-EOB-DTPA hepatobiliary phase for evaluating liver fibrosis in rabbits[J]. Chin J Magn Reson Imaging, 2021, 12(7): 45-50. DOI:10.12015/issn.1674-8034.2021.07.009.


[Abstract] Objective To explore parameters derived from whole-liver histogram analysis (HA) with Gd-EOB-DTPA enhanced MRI hepatobiliary phase in quantitatively evaluating liver fibrosis (LF). Materials andMethods One hundred rabbits were randomly divided into CCl4-induced LF group (n=80) and control group (n=20), and then were scheduled for hepatobiliary phase imaging examination. Whole-liver region of interest was drawn, and histogram analysis metrics including minimum, maximum, mean, median, skewness, kurtosis, inhomogeneity, entropy, and nth percentiles were extracted from hepatobiliary phase. Parameters were compared among different LF stages using Mann-Whitney U test and receivers operating characteristic curve, using histopathological results as reference standard.Results Eighty-four patients were enrolled, 18, 17, 17, 18, and 14 rabbits were pathologically diagnosed as F0—F4, respectively. HA parameters including the inhomogeneity (r=0.809), 90th (r=0.718), 75th (r=0.645), entropy (r=0.546), median (r=0.425) and kurtosis (r=0.305) of hepatobiliary phase demonstrated significant positive correlation with increasing fibrosis stage (P＜0.05). Inhomogeneity, 90th, 75th and entropy were of value in different normal (F0), early stage (F1—F2) and advanced (F3—F4) stage. The inhomogeneity parameter demonstrated higher diagnostic efficacy than other histogram analysis parameters in fibrosis staging, with an AUC value of 0.87 for F0 vs. F1—F4, 0.77 for F0 vs. F1—F2, 0.90 for F1—F2 vs. F3—F4, and 0.97 for F0 vs. F3—F4.Conclusions Histogram analysis of Gd-EOB-DTPA enhanced MRI hepatobiliary phase provide higher diagnostic value in distinguishing LF stages, which can be served as an effective imaging alternative in staging LF.
[Keywords] gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid；hepatobiliary phase；histogram analysis；liver fibrosis；magnetic resonance imaging；experiment study

LI Yufeng   LIU Haifeng   WANG Qing   DU Ya'nan   ZHU Zuhui   XING Wei*  

Department of Radiology, Third Affiliated Hospital of Soochow University, Changzhou 213003, China

Xing W, E-mail: suzhxingwei@suda.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81771798). Science and Technology Project of Jiangsu Province (No. BE2018646). Youth Project of Changzhou Health Commission (No. QN202022).
Received  2021-03-04
Accepted  2021-04-19
DOI: 10.12015/issn.1674-8034.2021.07.009
Cite this article as: Li YF, Liu HF, Wang Q, et al. Study of whole-liver histogram analysis based on Gd-EOB-DTPA hepatobiliary phase for evaluating liver fibrosis in rabbits[J]. Chin J Magn Reson Imaging, 2021, 12(7): 45-50. DOI:10.12015/issn.1674-8034.2021.07.009.

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