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The correlation between intravoxel incoherent motion and microvessel density and pathological differentiation of cervical cancer
RAN Yiting  BEI Guiguang 

Cite this article as: Ran YT Bei GG. The correlation between intravoxel incoherent motion and microvessel density and pathological differentiation of cervical cancer[J]. Chin J Magn Reson Imaging, 2021, 12(7): 72-76. DOI:10.12015/issn.1674-8034.2021.07.015.


[Abstract] Objective To analyse the value of intravoxel incoherent motion (IVIM) diffusion weighted imaging and histological microvessel density (MVD) in grading of cervical cancer and to investigate their correlation. Materials andMethods Twenty-six patients with pathologically proved cervical cancer were analysed retrospectively. They were divided into G1 group (highly differentiated), G2 group (moderately differentiated) and G3 group (poorly differentiated) according to pathology grading of cervical cancer. All patients underwent IVIM MRI. The IVIM parameters (ADC, D, D*, f, fD*) were assessed. And these parameters were correlated with MVD. The MVD were determined with the CD34 stain. Kruskal-Wallis H test was used to compare differences of parameters among three groups. Spearman's rank correlation analysis was used to evaluate the correlation of parameters and pathology grading and the correlation between IVIM parameters and MVD.Results IVIM parameters, like D value and D* value, showed statistical difference among three groups (P=0.009、P=0.003). Pairwise comparison showed that D had significant difference (P＜0.05). Comparing with G1 and G3, G2 and G3, D* value showed significant difference. D value decreased with the increase of differentiation level (that is, the lowest median value of D value in the low-differentiation group). While the value of D* decreased gradually with the increase of differentiation level. The MVD was statistically significant among the three groups (P＜0.05). The correlation between IVIM parameters D* value and MVD was statistically significant (P＜0.05), showing a linear correlation (r2=-0.554).Conclusions IVIM parameters (D、D*) and MVD have certain diagnostic value for cervical cancer grading. Besides, D* might be used in the noninvasive evalution of MVD.
[Keywords] cervical cancer；diffusion weighted imaging；intravoxel incoherent motion；microvessel density

RAN Yiting1, 2   BEI Guiguang3*  

1 Department of Radiology, Northern Theater Command General Hospital of China Medical University, Shenyang 110812, China

2 Chengdu Women's and Children's Central Hospital, University of Electroni Science and Technology of China,Chengdu 611731, China

3 Department of Radiology, General Hospital of Northern Theater Command, Shenyang 110812, China

Bei GG, E-mal: 2023477349@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Key Project of Natural Science Foundation of Liaoning Province (No. 20170540916).
Received  2021-02-25
Accepted  2021-05-13
DOI: 10.12015/issn.1674-8034.2021.07.015
Cite this article as: Ran YT Bei GG. The correlation between intravoxel incoherent motion and microvessel density and pathological differentiation of cervical cancer[J]. Chin J Magn Reson Imaging, 2021, 12(7): 72-76. DOI:10.12015/issn.1674-8034.2021.07.015.

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