Share：
Share this content in WeChat
X
[Chinese][PDF]1212109
• Review •
Advances in the evaluation of liver reserve function by Gd-EOB-DTPA-MRI
DING Cong  BAI Genji 

Cite this article as: Ding C, Bai GJ. Advances in the evaluation of liver reserve function by Gd-EOB-DTPA-MRI[J]. Chin J Magn Reson Imaging, 2021, 12(8): 104-107. DOI:10.12015/issn.1674-8034.2021.08.024.


[Abstract] Gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) is a hepatocyte specific contrast agent, which can evaluate the liver morphology and function at the same time, while the accurate assessment of liver reserve function is helpful to reduce postoperative complications of hepatectomy and improves the prognosis of chronic liver disease. This paper systematically expounds the principle and current situation of Gd-EOB-DTPA in the evaluation of liver function and forecasts the future research direction of Gd-EOB-DTPA.
[Keywords] Gd-EOB-DTPA；liver reserve function；magnetic resonance imaging；chronic liver disease

DING Cong   BAI Genji*  

Department of Radiology, the Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian 223300, China

Bai GJ, E-mail: hybgj0451@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS This work was part of Beijing Medical Health Public Welfare Fund (No.B20240ES).
Received  2021-02-05
Accepted  2021-03-05
DOI: 10.12015/issn.1674-8034.2021.08.024
Cite this article as: Ding C, Bai GJ. Advances in the evaluation of liver reserve function by Gd-EOB-DTPA-MRI[J]. Chin J Magn Reson Imaging, 2021, 12(8): 104-107. DOI:10.12015/issn.1674-8034.2021.08.024.

1
Yang T, Wu MC. Discrimination against hepatitis B carriers in China[J]. Lancet, 2011, 378(9796): 1059. DOI: 10.1016/S0140-6736(11)61460-8.
2
Wang YY, Zhao XH, Ma L, et al. Comparison of the ability of Child-Pugh score, MELD score, and ICG-R15 to assess preoperative hepatic functional reserve in patients with hepatocellular carcinoma[J]. J Surg Oncol, 2018, 118(3): 440-445. DOI: 10.1002/jso.25184.
3
Gu J, Zhang EL, Liang BY, et al. Effectiveness comparison of indocyanine green retention test with the cirrhotic severity scoring in evaluating the pathological severity of liver cirrhosis in patients with hepatocellular carcinoma and Child-Pugh grade A liver function[J]. World J Surg Oncol, 2020, 18(1): 79. DOI: 10.1186/s12957-020-01854-3.
4
Ho Shu-Yein, Po-Hong Liu, Hsu Chia-Yang, et al. Comparison of twelve liver functional reserve models for outcome prediction in patients with hepatocellular carcinoma undergoing surgical resection[J]. Sci Reports, 2018, 8(1): 4773. DOI: 10.1038/s41598-018-22923-4.
5
Zhao SJ, Wang MM, Yang ZY, et al. Comparison between Child-Pugh score and Albumin-Bilirubin grade in the prognosis of patients with HCC after liver resection using time-dependent ROC[J]. Annals Translat Med, 2020, 8(8): 539. DOI: 10.21037/atm.2020.02.85.
6
Hiraoka A, Kumada T, Michitaka K, et al. Newly proposed ALBI grade and ALBI-T score as tools for assessment of hepatic function and prognosis in hepatocellular carcinoma patients[J]. Liver Cancer, 2019, 8(5): 312-325. DOI: 10.1159/000494844.
7
Zou H, Wen Y, Yuan K, et al. Combining albumin-bilirubin score with future liver remnant predicts post-hepatectomy liver failure in HBV-associated HCC patients[J]. Liver Int, 2018, 38(3): 494-502. DOI: 10.1111/liv.13514.
8
Mai RY, Zeng J, Lu HZ, et al. Combining aspartate aminotransferase-to-platelet ratio index with future liver remnant to assess preoperative hepatic functional reserve in patients with hepatocellular carcinoma[J]. J Gastrointest Surg, 2020, 25(3): 688-697. DOI: 10.1007/s11605-020-04575-w.
9
Theilig D, Tsereteli A, Elkilany A, et al. Gd-EOB-DTPA-enhanced MRI T1 relaxometry as an imaging-based liver function test compared with (13)C-methacetin breath test[J]. Acta Radiol (Stockholm, Sweden: 1987), 2020, 61(3): 291-301. DOI: 10.1177/0284185119861314.
10
Rajakannu M, Cherqui D, Ciacio O, et al. Liver stiffness measurement by transient elastography predicts late posthepatectomy outcomes in patients undergoing resection for hepatocellular carcinoma[J]. Surgery, 2017, 162(4): 766-774. DOI: 10.1016/j.surg.2017.06.006.
11
Charing Ching-Ning Chong, Grace Lai-Hung Wong, Anthony Wing-Hung Chan, et al. Liver stiffness measurement predicts high-grade post-hepatectomy liver failure: A prospective cohort study[J]. J Gastroenterol Hepatology, 2017, 32(2): 506-514. DOI: 10.1111/jgh.13503.
12
Shen YH, Zhou CH, Zhu GD, et al. Liver stiffness assessed by shear wave elastography predicts postoperative liver failure in patients with hepatocellular carcinoma[J]. J Gastrointestinal Surg, 2017, 21(9): 1471-1479. DOI: 10.1007/s11605-017-3443-9.
13
Sugiura R, Kuwatani M, Nishida M, et al. Correlation between liver elasticity by ultrasound elastography and liver functional reserve[J]. Ultrasound in Med Biology, 2019, 45(10): 2704-2712. DOI: 10.1016/j.ultrasmedbio.2019.06.407.
14
Nishio T, Taura K, Koyama Y, et al. Prediction of posthepatectomy liver failure based on liver stiffness measurement in patients with hepatocellular carcinoma[J]. Surgery, 2016, 159(2): 399-408. DOI: 10.1016/j.surg.2015.06.024.
15
Yi HM, Cai BH, Ai X, et al. Value of contrast-enhanced ultrasound for preoperative assessment of liver reserve function in patients with liver tumors[J]. PLoS One, 2019, 14(9): e0222514. DOI: 10.1371/journal.pone.0222514.
16
Zheng JL, Xie W, Huang Y, et al. The technique of 3D reconstruction combining with biochemistry to build an equivalent formula of indocyanine green (ICG) clearance test to assess the liver reserve function[J]. BMC Surg, 2020, 20(1): 283. DOI: 10.1186/s12893-020-00952-z.
17
Beppu T, Hayashi H, Okabe H, et al. Liver functional volumetry for portal vein embolization using a newly developed 99mTc-galactosyl human serum albumin scintigraphy SPECT-computed tomography fusion system[J]. J Gastroenterol, 2011, 46(7): 938-943. DOI: 10.1007/s00535-011-0406-x.
18
Sumiyoshi T, Shima Y, Tokorodani R, et al. CT/99mTc-GSA SPECT fusion images demonstrate functional differences between the liver lobes[J]. World J Gastroenterol, 2013, 19(21): 3217-3225. DOI: 10.3748/wjg.v19.i21.3217.
19
Xia YX, Zhang L, Zhao YH, et al. Gallium-68-labelled indocyanine green as a potential liver reserve imaging agent[J]. Contrast Media & Molecular Imaging, 2019, 2019: 4201353. DOI: 10.1155/2019/4201353.
20
Katsube T, Okada M, Kumano S, et al. Estimation of liver function using T1 mapping on Gd-EOB-DTPA-enhanced magnetic resonance imaging[J]. Invest Radiol, 2011, 46(4): 277-283. DOI: 10.1097/RLI.0b013e318200f67d.
21
Zhang T, Runge JH, Lavini C, et al. A pharmacokinetic model including arrival time for two inputs and compensating for varying applied flip-angle in dynamic gadoxetic acid-enhanced MR imaging[J]. PLoS One, 2019, 14(8): e0220835. DOI: 10.1371/journal.pone.0220835.
22
Yamada A, Hara T, Li F, et al. Quantitative evaluation of liver function with use of gadoxetate disodium-enhanced MR imaging[J]. Radiology, 2011, 260(3): 727-33. DOI: 10.1148/radiol.11100586.
23
Haimerl M, Verloh N, Zeman F, et al. Gd-EOB-DTPA-enhanced MRI for evaluation of liver function: Comparison between signal-intensity-based indices and T1 relaxometry[J]. Sci Reports, 2017, 7: 43347. DOI: 10.1038/srep43347.
24
Araki K, Harimoto N, Kubo N, et al. Functional remnant liver volumetry using Gd-EOB-DTPA-enhanced magnetic resonance imaging (MRI) predicts post-hepatectomy liver failure in resection of more than one segment[J]. HPB (Oxford), 2020, 22(2): 318-327. DOI: 10.1016/j.hpb.2019.08.002.
25
Tajima T, Takao H, Akai H, et al. Relationship between liver function and liver signal intensity in hepatobiliary phase of gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging[J]. J Comput Assisted Tomography, 2010, 34(3): 362-366. DOI: 10.1097/RCT.0b013e3181cd3304.
26
Xie S, Sun YL, Wang L, et al. Assessment of liver function and liver fibrosis with dynamic Gd-EOB-DTPA-enhanced MRI[J]. Acade Radiol, 2015, 22(4): 460-466. DOI: 10.1016/j.acra.2014.11.006.
27
Yoon JH, Choi JI, Jeong YY, et al. Pre-treatment estimation of future remnant liver function using gadoxetic acid MRI in patients with HCC[J]. J Hepatol, 2016, 65(6): 1155-1162. DOI: 10.1016/j.jhep.2016.07.024.
28
Okada M, Ishii K, Numata K, et al. Can the biliary enhancement of Gd-EOB-DTPA predict the degree of liver function?[J]. HBPD Int, 2012, 11(3): 307-313. DOI: 10.1016/s1499-3872(12)60165-9.
29
Tschirch FTC, Struwe A, Petrowsky H, et al. Contrast-enhanced MR cholangiography with Gd-EOB-DTPA in patients with liver cirrhosis: visualization of the biliary ducts in comparison with patients with normal liver parenchyma[J]. Eur Radiol, 2008, 18(8): 1577-1586. DOI: 10.1007/s00330-008-0929-6.
30
Fahlenkamp UL, Ziegeler K, Adams LC, et al. Intracellular accumulation capacity of gadoxetate: initial results for a novel biomarker of liver function[J]. Sci Reports, 2020, 10(1): 18104. DOI: 10.1038/s41598-020-75145-y.
31
Luetkens JA, Klein S, Träber F, et al. Quantification of liver fibrosis at T1 and T2 mapping with extracellular volume fraction MRI: Preclinical results[J]. Radiology, 2018, 288(3): 748-754. DOI: 10.1148/radiol.2018180051.
32
Liu MT, Zhang XQ, Lu J, et al. Evaluation of liver function using the hepatocyte enhancement fraction based on gadoxetic acid-enhanced MRI in patients with chronic hepatitis B[J]. Abdominal Radiol (New York), 2020, 45(10): 3129-3135. DOI: 10.1007/s00261-020-02478-7.
33
Asenbaum U, Kaczirek K, Ba-Ssalamah A, et al. Post-hepatectomy liver failure after major hepatic surgery: not only size matters[J]. Eur Radiol, 2018, 28(11): 4748-4756. DOI: 10.1007/s00330-018-5487-y.
34
Theilig D, Steffen I, Malinowski M, et al. Predicting liver failure after extended right hepatectomy following right portal vein embolization with gadoxetic acid-enhanced MRI[J]. Eur Radiol, 2019, 29(11): 5861-5872. DOI: 10.1007/s00330-019-06101-2.
35
Kim DK, Choi JI, Choi MH, et al. Prediction of posthepatectomy liver failure: MRI with hepatocyte-specific contrast agent versus indocyanine green clearance test[J]. AJR Am J Roentgenol, 2018, 211(3): 580-587. DOI: 10.2214/AJR.17.19206.
36
Poetter-Lang S, Bastati N, Messner A, et al. Quantification of liver function using gadoxetic acid-enhanced MRI[J]. Abdominal Radiol (New York), 2020, 45(11): 3532-3544. DOI: 10.1007/s00261-020-02779-x.
37
Bernard E Van Beers, Garteiser P, Leporq B, et al. Quantitative imaging in diffuse liver diseases[J]. Seminars Liver Dis, 2017, 37(3): 243-258. DOI: 10.1055/s-0037-1603651.
38
Yang DW, Li D, Li JS, et al. Systematic review: The diagnostic efficacy of gadoxetic acid-enhanced MRI for liver fibrosis staging[J]. Eur J Radiol, 2020, 125: 108857. DOI: 10.1016/j.ejrad.2020.108857.
39
Feier D, Balassy C, Bastati N, et al. The diagnostic efficacy of quantitative liver MR imaging with diffusion-weighted, SWI, and hepato-specific contrast-enhanced sequences in staging liver fibrosis--a multiparametric approach[J]. Eur Radiol, 2016, 26(2): 539-546. DOI: 10.1007/s00330-015-3830-0.
40
Hoffman DH, Ayoola A, Nickel D, et al. T1 mapping, T2 mapping and MR elastography of the liver for detection and staging of liver fibrosis[J]. Abdominal Radiol (New York), 2020, 45(3): 692-700. DOI: 10.1007/s00261-019-02382-9.
41
Bastati N, Beer L, Mandorfer M, et al. Does the functional liver imaging score derived from gadoxetic acid-enhanced MRI predict outcomes in chronic liver disease?[J]. Radiology, 2020, 294(1): 98-107. DOI: 10.1148/radiol.2019190734.
42
Truhn D, Kuhl CK, Ciritsiset A, al. A new model for MR evaluation of liver function with gadoxetic acid, including both uptake and excretion[J]. Eur Radiol, 2019, 29(1): 383-391. DOI: 10.1007/s00330-018-5500-5.

PREV Advance in multicenter research of hepatocellular carcinoma based on radiomics
NEXT Clinical research progress of radiomics in pancreatic cancer
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn