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• Original Article •
The effects of repetitive transcranial magnetic stimulation on the left executive control network in heroin dependent individuals: a resting-state fMRI study
JIN Long  FU Yanwen  WANG Shu  ZHANG Wei  WEI Yixin  WANG Wei  YUAN Menghui  LI Qiang  WEI Longxiao 

Cite this article as: Jin L, Fu YW, Wang S, et al. The effects of repetitive transcranial magnetic stimulation on the left executive control network in heroin dependent individuals: a resting-state fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(9): 40-44. DOI:10.12015/issn.1674-8034.2021.09.009.


[Abstract] Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the left executive control network (ECN) in heroin dependent individuals. Materials andMethods Nineteen heroin dependent individuals (rTMS group) and 22 healthy control subjects (HC group) matched with age, sex and education level were included. The fMRI and behavioral data of the rTMS group were collected before and after treatment, and the fMRI data of the HC group were collected. The differences of cue-induced craving and left ECN before and after treatment in the rTMS group were analyzed.Results The heroin cue-induced craving score of the rTMS group after treatment (1.47±2.61) was significantly decreased than before treatment (1.82±2.91) (P＜0.05). The abnormally increased functional connectivity between the left dorsolateral prefrontal cortex (DLPFC) and the right DLPFC (MINI coordinate: x=27, y=39, z=51; voxels: 73; corrected by GRF, P＜0.05) was significantly decreased in the rTMS group after treatment with similar tendency toward that of the HC group.Conclusions It suggested that rTMS can reduce drug cue-induced craving of heroin dependent individuals and help restore abnormal left ECN function of heroin dependent individuals.
[Keywords] repetitive transcranial magnetic stimulation；heroin addiction；left executive control network；functional connectivity；functional magnetic resonance imaging

JIN Long1   FU Yanwen2   WANG Shu3   ZHANG Wei1   WEI Yixin1   WANG Wei1   YUAN Menghui1   LI Qiang4   WEI Longxiao1*  

1 Department of Nuclear Medicine,Tangdu Hospital, the Air Force Military Medical University, Xi'an 710038, China

2 Department of Neurology, Rugao Fourth People's Hospital, Jiangsu Province, Rugao 226511, China

3 MR Division, Canon Medical Systems (China) Co., LTD, Xi'an 710016, China

4 Department of Radiology, Tangdu Hospital, The Air Force Military Medical University, Xi'an 710038, China

Wei LX, E-mail: weilx3245@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Nature Science Foundation of China (No. 81671661). Top Talents of Tangdu Hospital (No. 2019).
Received  2021-04-30
Accepted  2021-06-23
DOI: 10.12015/issn.1674-8034.2021.09.009
Cite this article as: Jin L, Fu YW, Wang S, et al. The effects of repetitive transcranial magnetic stimulation on the left executive control network in heroin dependent individuals: a resting-state fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(9): 40-44. DOI:10.12015/issn.1674-8034.2021.09.009.

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