Share：
Share this content in WeChat
X
[Chinese][PDF]64195
• Original Article •
The effects of repetitive transcranial magnetic stimulation on the left executive control network in heroin dependent individuals: a resting-state fMRI study
JIN Long  FU Yanwen  WANG Shu  ZHANG Wei  WEI Yixin  WANG Wei  YUAN Menghui  LI Qiang  WEI Longxiao 

Cite this article as: Jin L, Fu YW, Wang S, et al. The effects of repetitive transcranial magnetic stimulation on the left executive control network in heroin dependent individuals: a resting-state fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(9): 40-44. DOI:10.12015/issn.1674-8034.2021.09.009.


[Abstract] Objective To investigate the effect of repetitive transcranial magnetic stimulation (rTMS) on the left executive control network (ECN) in heroin dependent individuals. Materials andMethods Nineteen heroin dependent individuals (rTMS group) and 22 healthy control subjects (HC group) matched with age, sex and education level were included. The fMRI and behavioral data of the rTMS group were collected before and after treatment, and the fMRI data of the HC group were collected. The differences of cue-induced craving and left ECN before and after treatment in the rTMS group were analyzed.Results The heroin cue-induced craving score of the rTMS group after treatment (1.47±2.61) was significantly decreased than before treatment (1.82±2.91) (P＜0.05). The abnormally increased functional connectivity between the left dorsolateral prefrontal cortex (DLPFC) and the right DLPFC (MINI coordinate: x=27, y=39, z=51; voxels: 73; corrected by GRF, P＜0.05) was significantly decreased in the rTMS group after treatment with similar tendency toward that of the HC group.Conclusions It suggested that rTMS can reduce drug cue-induced craving of heroin dependent individuals and help restore abnormal left ECN function of heroin dependent individuals.
[Keywords] repetitive transcranial magnetic stimulation；heroin addiction；left executive control network；functional connectivity；functional magnetic resonance imaging

JIN Long1   FU Yanwen2   WANG Shu3   ZHANG Wei1   WEI Yixin1   WANG Wei1   YUAN Menghui1   LI Qiang4   WEI Longxiao1*  

1 Department of Nuclear Medicine,Tangdu Hospital, the Air Force Military Medical University, Xi'an 710038, China

2 Department of Neurology, Rugao Fourth People's Hospital, Jiangsu Province, Rugao 226511, China

3 MR Division, Canon Medical Systems (China) Co., LTD, Xi'an 710016, China

4 Department of Radiology, Tangdu Hospital, The Air Force Military Medical University, Xi'an 710038, China

Wei LX, E-mail: weilx3245@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Nature Science Foundation of China (No. 81671661). Top Talents of Tangdu Hospital (No. 2019).
Received  2021-04-30
Accepted  2021-06-23
DOI: 10.12015/issn.1674-8034.2021.09.009
Cite this article as: Jin L, Fu YW, Wang S, et al. The effects of repetitive transcranial magnetic stimulation on the left executive control network in heroin dependent individuals: a resting-state fMRI study[J]. Chin J Magn Reson Imaging, 2021, 12(9): 40-44. DOI:10.12015/issn.1674-8034.2021.09.009.

[1]
China National Narcotics Control Committee.2019 China Drug Situation Report[R/OL]. 2020. http://www. nncc626. com/2020-06/24/c_1210675813.htm.
[2]
Volkow ND, Wang G, Fowler JS, et al. Addiction: beyond dopamine reward circuitry[J]. P Natl Acad Sci Usa, 2011, 108(37): 15037-15042. DOI: 10.1073/pnas.1010654108.
[3]
Wadman M. Zapping cocaine addiction[J]. Science, 2017, 357(6355): 960-963. DOI: 10.1126/science.357.6355.960.
[4]
Bolloni C, Badas P, Corona G, et al. Transcranial magnetic stimulation for the treatment of cocaine addiction: evidence to date[J]. 2018, 9: 11-21. DOI: 10.2147/SAR.S161206.
[5]
Su H, Zhong N, Gan H, et al. High frequency repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex for methamphetamine use disorders: a randomised clinical trial[J]. Drug Alcohol Depen, 2017, 175:84-91. DOI: 10.1016/j.drugalcdep.2017.01.037.
[6]
Hauer L, Scarano G I, Brigo F, et al. Effects of repetitive transcranial magnetic stimulation on nicotine consumption and craving: a systematic review[J]. Psychiat Res, 2019, 281: 112562. DOI: 10.1016/j.psychres.2019.112562.
[7]
Sahlem GL, Baker NL, George MS, et al. Repetitive transcranial magnetic stimulation (rTMS) administration to heavy cannabis users[J]. The Am J Drug Alcohol Abuse, 2018, 44(1): 47-55. DOI: 10.1080/00952990.2017.1355920.
[8]
Shi H, Chen JJ, Wang F, et al. Functional magnetic resonance imaging study on the effects of craving task on large-scale brain networks in heroin addicts. Chin J Magn Reson Imaging, 2019, 10(3): 161-168. DOI: 10.12015/issn.1674-8034.2019.03.001.
[9]
Li Q, Liu J, Wang W, et al. Disrupted coupling of large-scale networks is associated with relapse behaviour in heroin-dependent men[J]. J Psychiatry Neurosci, 2018(1): 48-57. DOI: 10.1503/jpn.170011.
[10]
Shen Y, Cao X, Tan T, et al. 10-Hz repetitive transcranial magnetic stimulation of the left dorsolateral prefrontal cortex reduces heroin cue craving in long-term addicts[J]. Biol Psychiat, 2016, 80(3): e13-e14. DOI: 10.1016/j.biopsych.2016.02.006.
[11]
Li X, Hartwell KJ, OWENS M, et al. Repetitive transcranial magnetic stimulation of the dorsolateral prefrontal cortex reduces nicotine cue craving[J]. Biol Psychiat, 2013, 73(8): 714-720. DOI: 10.1016/j.biopsych.2013.01.003.
[12]
Li Q, Li W, Wang H, et al. Predicting subsequent relapse by drug-related cue-induced brain activation in heroin addiction: an event-related functional magnetic resonance imaging study[J]. Addict Biol, 2015, 20(5): 968-978. DOI: 10.1111/adb.12182.
[13]
Wang XX, Zhao N, Dong XL, et al. Advances in transcranial magnetic stimulation for intervention of substance dependence. Pract Clin Med, 2020, 21(5): 80-85. DOI: 10.13764/j.cnk.lcsy.2020.05.030.
[14]
Song H, Fang LZ, Ye XG, et al. A study on the clinical effect of repetitive transcranial magnetic stimulation on the improvement of heroin protracted withdrawal syndrome. Journal of Chengdu Med College J, 2017, 12(5): 590-593. DOI: 10.3969/j.issn.1674-2257.2017.05.014.
[15]
Bressler SL, Menon V. Large-scale brain networks in cognition: emerging methods and principles[J]. Trends Cogn Sci, 2010, 14(6): 277-290. DOI: 10.1016/j.tics.2010.04.004.
[16]
Goldstein RZ, Volkow ND. Dysfunction of the prefrontal cortex in addiction: neuroimaging findings and clinical implications[J]. Nat Rev Neurosci, 2011, 12(11): 652-669. DOI: 10.1038/nrn3119.
[17]
Yang WC, Wang YR, Li Q, et al. The altered functional connectivity of prefrontal cortex in heroin dependent Individuals: fMRI Study. J Pract Radiol, 2011, 27(2): 153-156. DOI: 10.3969/j.issn.1002-1671.2011.02.001.
[18]
Jin L, Zhang W, Huang YF, et al. Characteristics of function of left executive control network in heroin addicts during methadone maintenance treatment: a resting-state fMRI study. Chin J Magn Reson Imaging, 2020, 11(3): 166-170. DOI: 10.12015/issn.1674-8034.2020.03.002.
[19]
van der Werf YD, Sanz-Arigita EJ, Menning S, et al. Modulating spontaneous brain activity using repetitive transcranial magnetic stimulation[J]. Bmc Neurosci, 2010, 11(1): 145. DOI: 10.1186/1471-2202-11-145.
[20]
Volkow ND, Wang G, Fowler JS, et al. Addiction circuitry in the human brain[J]. Annu Rev Pharmacol, 2012, 52(1): 321-336. DOI: 10.1146/annurev-pharmtox-010611-134625.
[21]
Hanlon CA, Dowdle LT, Moss H, et al. Mobilization of medial and lateral frontal-striatal circuits in cocaine users and controls: an interleaved TMS/BOLD functional connectivity study[J]. Neuropsychopharmacol, 2016, 41(13): 3032-3041. DOI: 10.1038/npp.2016.114.
[22]
Li X, Du L, Sahlem GL, et al. Repetitive transcranial magnetic stimulation (rTMS) of the dorsolateral prefrontal cortex reduces resting-state insula activity and modulates functional connectivity of the orbitofrontal cortex in cigarette smokers[J]. Drug Alcohol Depen, 2017, 174: 98-105. DOI: 10.1016/j.drugalcdep.2017.02.002.
[23]
Su H, Liu Y, Yin D, et al. Neuroplastic changes in resting-state functional connectivity after rTMS intervention for methamphetamine craving[J]. Neuropharmacology, 2020, 175:108177. DOI: 10.1016/j.neuropharm.2020.108177.

PREV The stronger sensitivity to missed chances in individuals with IGD: a resting-state fMRI study
NEXT Brain gray matter volume and functional brain network in patients with lower back pain: a MRI study
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn