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• Original Article •
Brain gray matter volume and functional brain network in patients with lower back pain: a MRI study
JIANG Jian  DU Wei  CUI Yunan  JIANG Yuhan  LIU Ailian  Miao Yanwei 

Cite this article as: Jiang J, Du W, Cui YN, et al. Brain gray matter volume and functional brain network in patients with lower back pain: a MRI study[J]. Chin J Magn Reson Imaging, 2021, 12(9): 45-48, 60. DOI:10.12015/issn.1674-8034.2021.09.010.


[Abstract] Objective To investigate the abnormalities of brain gray matter (GM) and the functional network changes in patients with lower back pain (LBP).Methods andMethods FMRI was performed on 20 individuals with LBP and 20 age and gender-matched healthy controls (HC). The GM volumes of the two groups were compared by voxel-based morphological (VBM) analysis. In order to reflect the network efficiency, network-based statistics were performed to explore the differences between the brain networks of patients with LBP and those with HC.Results In comparison of HC, patients with LBP showed reduced GM volumes in several brain cortical areas (P＜0.001). The brain networks in LBP showed a significantly longer characteristic path length as well as a lower clustering coefficient (P＜0.001), global efficiency (P=0.001) and local efficiency (P＜0.001) compared with HC, which led to unstable and inefficient brain networks. In addition, LBP patients showed significantly decreased functional connectivity in several brain areas (P＜0.001).Conclusions LBP will result in the volume reduction of GM and the damage of the topological properties of the functional brain network. Our results provide a further insight into the neural mechanisms behind LBP.
[Keywords] brain functional network；voxel-based morphological；lower back pain；functional magnetic resonance imaging, brain gray matter

JIANG Jian   DU Wei   CUI Yunan   JIANG Yuhan   LIU Ailian   Miao Yanwei*  

Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116000, China

Miao YW, E-mail: ywmiao716@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS The Education Department of Liaoning Province Foundation (No. LZ2019047).
Received  2021-04-23
Accepted  2021-06-03
DOI: 10.12015/issn.1674-8034.2021.09.010
Cite this article as: Jiang J, Du W, Cui YN, et al. Brain gray matter volume and functional brain network in patients with lower back pain: a MRI study[J]. Chin J Magn Reson Imaging, 2021, 12(9): 45-48, 60. DOI:10.12015/issn.1674-8034.2021.09.010.

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