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The correlation between diffusion kurtosis imaging and pathological condition in clear cell renal carcinoma
FENG Qiang  ZHANG Ruiming  FANG Wei  MA Zhijun 

Cite this article as: Feng Q, Zhang RM, Fang W, et al. The correlation between diffusion kurtosis imaging and pathological condition in clear cell renal carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(9): 57-60. DOI:10.12015/issn.1674-8034.2021.09.013.


[Abstract] Objective To investigate if the mean diffusivity (MD) and mean kurtosis (MK) allows assessment of pathological condition of clear cell renal cell carcinoma (CCRCC), including microvessel density (MVD), microvessel area (MVA), and Ki-67. Materials andMethods Thirty-three patients were enrolled in this study, with CCRCC confirmed by surgical pathology. For diffusion kurtosis imaging (DKI), a coronal echo planar imaging (EPI) sequence was performed (repetition time: 4000 ms; echo time: 99 ms; diffusion direction: 3; number of acquisitions: 4; b=0, 800, and 1600 s/mm2; and slice thickness: 4 mm with no intersection gap). MD, MK, MVD, MVA, and Ki-67 were compared between the different nuclear grades. Correlations between MVD, MVA, and Ki-67 and DKI parameters were evaluated.Results The MDs of low grade and high grade CCRCCs were (2.43±0.11)×10-3 mm2/s and (2.22±0.07)×10-3 mm2/s, respectively. The MK was 0.73±0.03 and 0.82±0.04, respectively. MK were better than MD values in identifying the grade of nuclear grade. A significant difference between high and low grade in MVD, MVA, and Ki-67 was found (t=-8.23, -15.47, and -7.84, respectively, P＜0.05). Significant negative correlations between the MD value and MVD, MVA, and Ki-67 were observed (r=-0.710, -0.746, and -0.733, respectively, P＜0.05). Significant positive correlations between the MK value and MVD, MVA, and Ki-67 were observed (r=0.787, 0.772, and 0.801, respectively, P＜0.05).Conclusions DKI can be used to noninvasively assess MVD, MVA, and Ki-67 of CCRCC.
[Keywords] diffusion；capillaries；cellular proliferation；clear cell renal cell carcinoma；magnetic resonance imaging

FENG Qiang*   ZHANG Ruiming   FANG Wei   MA Zhijun  

Department of CT-MR, Yidu Central Hospital Affiliated to Weifang Medical College of Shandong Province, Qingzhou 262500, China

Feng Q, E-mail: fengyijun2018@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Projects of Medical and Health Technology Development Program in Shandong Province (No. 2016WS0663).
Received  2021-03-17
Accepted  2021-05-08
DOI: 10.12015/issn.1674-8034.2021.09.013
Cite this article as: Feng Q, Zhang RM, Fang W, et al. The correlation between diffusion kurtosis imaging and pathological condition in clear cell renal carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(9): 57-60. DOI:10.12015/issn.1674-8034.2021.09.013.

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