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Diagnostic value of DCE-MRI combined with DWI for central gland prostate cancer
LUO Yongzhi  WANG Xi 

Cite this article as: Luo YZ, Wang X. Diagnostic value of DCE-MRI combined with DWI for central gland prostate cancer[J]. Chin J Magn Reson Imaging, 2021, 12(9): 61-64. DOI:10.12015/issn.1674-8034.2021.09.014.


[Abstract] Objective To explore the application value of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) and diffusion-weighted imaging (DWI) in the diagnosis of central gland prostate cancer (CGPCa). Materials andMethods The clinical data of 113 patients with prostate diseases confirmed by needle biopsy or surgical pathology in the hospital between January 2017 and January 2020 were retrospectively analyzed. According to the disease type, the patients were divided into CGPCa group (n=51) and benign prostatic hyperplasia group (BPH group, n=62). All patients were subjected to routine MR, DCE-MRI and DWI scanning. The MR images of the two groups were analyzed. The DCE-MRI quantitative parameters and apparent diffusion coefficient (ADC) values were compared between the two groups and between patients with different degrees of CGPCa. The receiver operating characteristic (ROC) curve was used to analyze the diagnostic value of DCE-MRI, DWI and their combination in CGPCa.Results The volume transfer (Ktrans) and rate constant (Kep) values of CGPCa group were significantly higher than those of BPH group (P＜0.001), and the ADC value was significantly lower than that of BPH group (P＜0.001), but there was no significant difference in the volume fraction (Ve) value between the two groups (P=0.391). In CGPCa group, the Ktrans and Kep values of the low-risk group were significantly lower than those of the middle and high-risk group (P＜0.001), and the ADC value was significantly higher than that of the middle and high-risk group (P＜0.001), but there was no significant difference in the Ve value between the two groups (P=0.249). ROC curve analysis results showed that the area under the curve (AUC) values of Ktrans, Kep, ADC value and their combined diagnosis were 0.732, 0.813, 0.862, and 0.901, respectively (P＜0.001). The sensitivity and specificity of combined diagnosis were higher than those of each index (P＜0.001).Conclusions Both DCE-MRI and DWI can be used for differential diagnosis of CGPCa. The quantitative parameters Ktrans, Kep value and ADC value of DCE-MRI can provide imaging reference for clinical differential diagnosis of CGPCa, and the combined diagnosis can further improve the diagnostic efficiency.
[Keywords] central gland prostate cancer；prostatic hyperplasia；dynamic contrast-enhanced magnetic resonance imaging；diffusion weighted imaging；diagnosis

LUO Yongzhi   WANG Xi*  

Department of Imaging, the Third Hospital of Changsha City, Hunan Province, Changsha 410003, China

Wang X, E-mail: wangxi15874081774@163.com

Conflicts of interest   None.

Received  2021-04-16
Accepted  2021-06-11
DOI: 10.12015/issn.1674-8034.2021.09.014
Cite this article as: Luo YZ, Wang X. Diagnostic value of DCE-MRI combined with DWI for central gland prostate cancer[J]. Chin J Magn Reson Imaging, 2021, 12(9): 61-64. DOI:10.12015/issn.1674-8034.2021.09.014.

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