Share：
Share this content in WeChat
X
[Chinese][PDF]81369
• Experience Exchanges •
Preliminary study of APT combined with T2 mapping sequence in preoperative risk assessment of endometrial carcinoma
MA Changjun  LIU Ailian  TIAN Shifeng  CHEN Lihua  WANG Nan  SONG Qingwei  LIN Liangjie  WANG Jiazheng  MENG Xing 

Cite this article as: Ma CJ, Liu AL, Tian SF, et al. Preliminary study of APT combined with T2 mapping sequence in preoperative risk assessment of endometrial carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(9): 69-72. DOI:10.12015/issn.1674-8034.2021.09.016.


[Abstract] Objective To investigate the value of amide proton metastasis (APT) combined with T2 mapping sequence in preoperative risk assessment of endometrial carcinoma (EC). Materials andMethods The imaging data of 27 cases of endometrioid adenocarcinoma (among them, there were 10 cases of G1 grade, 11 cases of G2 grade and 6 cases of G3 grade) confirmed by surgery and pathology were retrospectively analyzed. All patients underwent 3.0 T magnetic resonance examination preoperatively, and the scanning sequence included APTw and T2 mapping. Patients were divided into high risk group and low risk group according to pathological type, pathological grade, degree of invasion and other factors. The APTw value of focal APT sequence and the T2 value of T2 mapping sequence were measured respectively by two observers. intraclass correlation coefficient (ICC) was used to test the consistency of measurement results of each parameter value between two observers. According to whether the data conform to normal distribution, independent sample t test or Mann-Whitney U test was used to compare the differences in the values of each parameter, and ROC curve was used to evaluate the efficiency of statistically different parameters in the differential diagnosis of EC in the high and low risk groups. Logistic regression was used to calculate the AUC of APTw combined with T2 mapping to identify EC in the high and low risk groups. DeLong test was used to compare the differences among AUC.Results The consistency of parameters of lesions measured by two observers was good (ICC＞0.75). The APT value of the high-risk group (2.825%±0.432%) was higher than that of the low-risk group (2.238%±0.314%), and the T2 value of the high-risk group [(77.234±7.722) ms] was lower than that of the low-risk group [(85.870±13.016) ms], the differences were statistically significant (t=-4.084, 2.164, P＜0.01, 0.040). AUC, sensitivity and specificity of APT value, T2 value and combined diagnosis of high-risk EC were 0.841, 70.0%, 94.1%, 0.674, 90.0%, 52.9%, 0.900, 80.0%, 88.2%, respectively. The P values of the differences between APTw, T2 mapping and combined AUC were 0.2315, 0.2292 and 0.0279, respectively.Conclusions APT value and T2 value can effectively and quantitatively evaluate the preoperative risk of EC, and it has a good prospect of clinical application.
[Keywords] amide proton transfer；endometrial carcinoma；magnetic resonance imaging；T2 mapping

MA Changjun1   LIU Ailian1*   TIAN Shifeng1   CHEN Lihua1   WANG Nan1   SONG Qingwei1   LIN Liangjie2   WANG Jiazheng2   MENG Xing3  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, dalian 116011, China

2 Philips Healthcare, Beijing 100036, China

3 Department of Radiology, Dalian Women and Children's Treatment Center, Dalian 116033

Liu AL, E-mail: cjr.liuailian@vip.163.com

Conflicts of interest   None.

Received  2021-03-22
Accepted  2021-05-28
DOI: 10.12015/issn.1674-8034.2021.09.016
Cite this article as: Ma CJ, Liu AL, Tian SF, et al. Preliminary study of APT combined with T2 mapping sequence in preoperative risk assessment of endometrial carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(9): 69-72. DOI:10.12015/issn.1674-8034.2021.09.016.

[1]
Ballester M, Bendifallah S, Daraï E, et al. European guidelines (ESMO-ESGO-ESTRO consensus conference) for the management of endometrial cancer[J]. Bull Cancer, 2017, 104(12): 1032-1038. DOI: 10.1016/j.bulcan.2017.10.006.
[2]
Feng ZY, Wen HW. Do lymph nodes need to be removed for stage I low-risk endometrial cancer?[J]. Chin J Radiol, 2016, 51(4): 315-317. DOI: 10.3760/cma.j.issn.0529-567x.2016.04.015.
[3]
Marin F, Plesca M, Bordea CI, et al. Postoperative surgical complications of lymphadenohysterocolpectomy[J]. J Med Life, 2014, 7(1): 60-66.
[4]
Shen YQ, Lv FJ, Xiao ZB, et al. Utility of the relative apparent diffusion coefficient for preoperative assessment of low risk endometrial carcinoma[J]. Clin Imaging, 2019, 56(2): 28-32. DOI: 10.1016/j.clinimag.2019.03.001.
[5]
Zhou J, Payen JF, Wilson DA, et al. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI[J]. Nat Med, 2003, 9(8): 1085-1090. DOI: 10.1038/nm907.
[6]
Hamlin SA, Henry TS, Little BP, et al. Mapping the future of cardiac MR imaging: case-based review of T1 and T2 mapping techniques[J]. Radiograohics, 2014, 34(6): 1594-1611. DOI: 10.1148/rg.346140030.
[7]
Lavaud P, Fedida B, Canlorbe G, et al. Preoperative MR imaging for ESMO-ESGO-ESTRO classification of endometrial cancer[J]. Diagn Interv Imaging, 2018, 99(6): 387-396. DOI: 10.1016/j.diii.2018.01.010.
[8]
Lavaud P, Fedida B, Canlorbe G, et al. Preoperative MR imaging for ESMO-ESGO-ESTRO classification of endometrial cancer[J]. Diagn Interv Imaging, 2018, 99(6): 387-396. DOI: 10.1016/j.diii.2018.01.010.
[9]
Liu N, Yin JZ. The research progress of amide proton transfer imaging in central nervous system[J]. Int J Med Radiol, 2018, 41(2), 151-154. DOI: 10.19300/j.2018.Z5172.
[10]
Lia BB, Sun HZ, Zhang SY, et al. The utility of APT and IVIM in the diagnosis and differentiation of squamoucell carcinoma of the cervix: a pilot study[J]. Magn Reson Imaging, 2019, 63(6): 105-113. DOI: 10.1016/j.mri.2019.08.020.
[11]
Choi YS, Ahn SS, Lee SK, et al. Amide proton transfer imaging to discriminate between low-and high-grade gliomas:added value to apparent diffusion coefficient and relative cerebral blood volume[J]. Eur Radiol, 2017, 27(8): 3181-3189. DOI: 10.1007/s00330-017-4732-0.
[12]
Durmo F, Rydhög A, Testud F, et al. Assessment of amide proton transfer weighted (APTw) MRI for pre-surgical prediction of final diagnosis in gliomas[J]. PLoS One, 2020, 15(12): e0244003. DOI: 10.1371/journal.pone.0244003.
[13]
Togao O, Yoshiura T, Keupp J, et al. Amide proton transfer imaging of adult diffuse gliomas: correlation with histopathological grades[J]. Neuro Oncol, 2014, 16(3): 441-448. DOI: 10.1093/neuonc/not158.
[14]
Colombo N, Creutzberg C, Amant F, et al. ESMO-ESGOESTRO consensus conference on endometrial cancer:diagnosis, treatment and follow-up[J]. Int J Gynecol Cancer, 2016, 26(1): 2-30. DOI: 10.1097/IGC.00000000000000609.
[15]
Meng XH, Wang Z, Li G, et al. Quantitative evaluation of knee cartilage and meniscus destruction in patients with rheumatoid arthritis using T1ρ and T2 mapping[J]. Eur Radiol, 2017, 96: 91-97. DOI: 10.1016/j.ejrad.2017.09.018.
[16]
Lockard CA, Chang A, Shin RC, et al. Regional variation of ankle and hindfoot cartilage T2 mapping values at 3 T: a feasibility study[J]. Eur Radiol, 2019, 113(2): 209-216. DOI: 10.1016/j.ejrad.2019.02.011.
[17]
Huang WR. Diagnostic value of T2 mapping and routine sequence for early cartilage injury[J]. Med Innovat China, 2019, 16(12): 46-49. DOI: 10.3969/j.issn.1674-4985.2019.12.012.
[18]
Mou J, Wang D, Liu XF, et al. The application value of T2-mapping sequence of cardiovascular magnetic resonance imaging to monitor myocardial inflammation in acute myocarditis[J]. Radiol pract, 2020, 35(11), 1424-1428. DOI: 10.13609/j.cnki.1000-0313.2020.11.011.
[19]
Lia Y, Lin CY, Qi YF, et al. Three-dimensional turbo-spin-echo amide proton transfer-weighted and intravoxel incoherent motion MR imaging for type I endometrial carcinoma: correlation with Ki-67 proliferation status[J]. Magn Reson Imaging, 2021, 78(12): 18-24. DOI: 10.1016/j.mri.2021.02.006.

PREV Application value of conventional MRI examination and diffusion weighted imaging in preoperative evaluation of rectal cancer
NEXT Diagnostic value of MRI in extra-abdominal desmoid type fibromatoses
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn