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Preliminary study of APT combined with T2 mapping sequence in preoperative risk assessment of endometrial carcinoma
MA Changjun  LIU Ailian  TIAN Shifeng  CHEN Lihua  WANG Nan  SONG Qingwei  LIN Liangjie  WANG Jiazheng  MENG Xing 

Cite this article as: Ma CJ, Liu AL, Tian SF, et al. Preliminary study of APT combined with T2 mapping sequence in preoperative risk assessment of endometrial carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(9): 69-72. DOI:10.12015/issn.1674-8034.2021.09.016.


[Abstract] Objective To investigate the value of amide proton metastasis (APT) combined with T2 mapping sequence in preoperative risk assessment of endometrial carcinoma (EC). Materials andMethods The imaging data of 27 cases of endometrioid adenocarcinoma (among them, there were 10 cases of G1 grade, 11 cases of G2 grade and 6 cases of G3 grade) confirmed by surgery and pathology were retrospectively analyzed. All patients underwent 3.0 T magnetic resonance examination preoperatively, and the scanning sequence included APTw and T2 mapping. Patients were divided into high risk group and low risk group according to pathological type, pathological grade, degree of invasion and other factors. The APTw value of focal APT sequence and the T2 value of T2 mapping sequence were measured respectively by two observers. intraclass correlation coefficient (ICC) was used to test the consistency of measurement results of each parameter value between two observers. According to whether the data conform to normal distribution, independent sample t test or Mann-Whitney U test was used to compare the differences in the values of each parameter, and ROC curve was used to evaluate the efficiency of statistically different parameters in the differential diagnosis of EC in the high and low risk groups. Logistic regression was used to calculate the AUC of APTw combined with T2 mapping to identify EC in the high and low risk groups. DeLong test was used to compare the differences among AUC.Results The consistency of parameters of lesions measured by two observers was good (ICC＞0.75). The APT value of the high-risk group (2.825%±0.432%) was higher than that of the low-risk group (2.238%±0.314%), and the T2 value of the high-risk group [(77.234±7.722) ms] was lower than that of the low-risk group [(85.870±13.016) ms], the differences were statistically significant (t=-4.084, 2.164, P＜0.01, 0.040). AUC, sensitivity and specificity of APT value, T2 value and combined diagnosis of high-risk EC were 0.841, 70.0%, 94.1%, 0.674, 90.0%, 52.9%, 0.900, 80.0%, 88.2%, respectively. The P values of the differences between APTw, T2 mapping and combined AUC were 0.2315, 0.2292 and 0.0279, respectively.Conclusions APT value and T2 value can effectively and quantitatively evaluate the preoperative risk of EC, and it has a good prospect of clinical application.
[Keywords] amide proton transfer；endometrial carcinoma；magnetic resonance imaging；T2 mapping

MA Changjun1   LIU Ailian1*   TIAN Shifeng1   CHEN Lihua1   WANG Nan1   SONG Qingwei1   LIN Liangjie2   WANG Jiazheng2   MENG Xing3  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, dalian 116011, China

2 Philips Healthcare, Beijing 100036, China

3 Department of Radiology, Dalian Women and Children's Treatment Center, Dalian 116033

Liu AL, E-mail: cjr.liuailian@vip.163.com

Conflicts of interest   None.

Received  2021-03-22
Accepted  2021-05-28
DOI: 10.12015/issn.1674-8034.2021.09.016
Cite this article as: Ma CJ, Liu AL, Tian SF, et al. Preliminary study of APT combined with T2 mapping sequence in preoperative risk assessment of endometrial carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(9): 69-72. DOI:10.12015/issn.1674-8034.2021.09.016.

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