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• Original Article •
The study of multi-nuclide 1H/19F-MR lung ventilation imaging based on atomized perfluorocarbon nanoprobe
JIANG Ying  CHEN Jing  DONG Jing  WU Lina 

Cite this article as: Jiang Y, Chen J, Dong J, et al. The study of multi-nuclide 1H/19F-MR lung ventilation imaging based on atomized perfluorocarbon nanoprobe[J]. Chin J Magn Reson Imaging, 2021, 12(10): 26-31. DOI:10.12015/issn.1674-8034.2021.10.006.


[Abstract] Objective To explore the feasibility of applying atomized perfluorocarbon nanoprobe (PFC NP) for multi-core 1H/19F magnetic resonance (1H/19F-MR) lung ventilation imaging. Materials andMethods The BALB/c mice were divided into air group and atomized PFC NP group to perform multi-core 1H/19F-MR scanning to study the distribution of PFC NPs in the lungs. 1H/19F-MR scans were performed at 0 h, 1 h, 4 h, 8 h, 12 h, 24 h, and 48 h to study the metabolic time of the aerosolized PFC NPs in the lungs. To verify the deposition of aerosolized PFC NPs in lung tissues and their effects on major tissues and organs through pathological examinations.Results The atomized PFC NPs can significantly enhance the 19F magnetic resonance (19F-MR) signal of bilateral lungs. And it was observed that the 19F signal enhancement in different lung fields is different. Among them, the 19F signal intensity difference between the upper and the lower lung fields, and between the middle and the lower lung fields is statistically significant (P＜0.01). By performing 1H/19F-MR imaging at each time point, it was found that the 19F signal began to attenuate at 8 h after the PFC NPs was delivered, significantly decreased at 24 h, and declined to the signal intensity of background at 48 h. Tissue sections confirmed the deposition of PFC NPs in lung tissue after delivery through the respiratory tract. H&E staining showed that no pathological damage was observed indifferent organs after the atomized PFC NP was delivered through the respiratory tract.Conclusions Multi-core 1H/19F-MR lung ventilation imaging based on atomized PFC NP can present the pulmonary anatomy and its ventilation information under physiological conditions. It is promising in the field of respiratory system magnetic resonance imaging.
[Keywords] lung ventilation；lung imaging；perfluorocarbon；multinuclear magnetic resonance； 19F magnetic resonance

JIANG Ying1, 2   CHEN Jing1, 2   DONG Jing1, 2   WU Lina1, 2*  

1 Department of Nuclear Medicine, the Fourth Hospital of Harbin Medical University, Harbin 150028, China

2 NHC and CAMS Key Laboratory of Molecular Probe and Targeted Theranostics, Molecular Imaging Research Center (MIRC), Harbin Medical University, Harbin 150028, China

Wu LN, E-mail: LinaWuHMU@hotmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No.81771903); National Reform and Development Funds for Local Universities (No.2020YQ04); Intra-hospital Fund of the Fourth Clinical Medical College of Harbin Medical University (HYDSYJQ201601).
Received  2021-04-22
Accepted  2021-07-02
DOI: 10.12015/issn.1674-8034.2021.10.006
Cite this article as: Jiang Y, Chen J, Dong J, et al. The study of multi-nuclide 1H/19F-MR lung ventilation imaging based on atomized perfluorocarbon nanoprobe[J]. Chin J Magn Reson Imaging, 2021, 12(10): 26-31. DOI:10.12015/issn.1674-8034.2021.10.006.

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