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• Technical Article •
Gd-EOB-DTPA-enhanced MRI for evaluation of hepatic reserve function:The value of hepatic signal intensity and histogram in hepatobiliary phase
LIAN Yuqing  XUE Xing  FENG Zhan  ZHENG Yan  CHEN Feng 

Cite this article as: Lian YQ, Xue X, Feng Z, et al. Gd-EOB-DTPA-enhanced MRI for evaluation of hepatic reserve function：The value of hepatic signal intensity and histogram in hepatobiliary phase[J]. Chin J Magn Reson Imaging, 2021, 12(10): 36-40. DOI:10.12015/issn.1674-8034.2021.10.008.


[Abstract] Objective To explore the value of hepatic signal intensity and histogram in hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI in evaluating hepatic reserve function. Materials andMethods A retrospective analysis of the clinical and imaging data of 87 patients has been conducted in our hospital from January 2014 to June 2019. The patients were classified into three groups according to abnormal liver function, including Child-Pugh grade A (58 cases), Child-Pugh grade B (15 cases) and Child-Pugh grade C (1 case). The patients with normal liver function (13 cases) were used as control group. One-way analysis of variance and pairwise comparison were done to analyze the difference among different liver function groups by using the relative enhancement at hepatobiliary phase (REHBP) and the histogram parameters at hepatobiliary phase of Gd-EOB-DTPA-enhanced MRI. The receiver operating characteristic curve (ROC) was used to evaluate the diagnostic performance of REHBP and histogram parameters between two groups of Child-Pugh A and Child-Pugh B+C, and Spearman correlation analysis was used to analyze the correlation between REHBP, histogram parameters and indocyanine green retention rate at 15 min (ICG R15).Results A significant difference of REHBP, skewness, minimum, 5th, 10th, 15th, 20th percentile and 0.025th percentile was found among the three groups (P values were＜0.001,＜0.001, 0.015, 0.026, 0.029, 0.034, 0.039, 0.025, P＜0.05). There was no significant difference of those parameters between the normal liver function group and Child-Pugh A group (P values are 0.610, 0.400, 0.410, 0.550, 0.610, 0.620, 0.660, 0.550, P＞0.05). Significant differences were found between the normal liver function group and Child-Pugh B+C group (P values were 0.017,＜0.001, 0.013, 0.017, 0.027, 0.030, 0.033, 0.019, P＜0.05) as well as between Child-Pugh A group and Child-Pugh B+C group (P values were＜0.001,＜0.001, 0.013, 0.013, 0.012, 0.015, 0.015, 0.013, P＜0.05). The area under ROC curve (AUC) for REHBP, skewness, minimum, 5th, 10th, 15th, 20th percentile and 0.025th quantile were 0.778, 0.816, 0.713, 0.713, 0.715, 0.708, 0.709 and 0.713 respectively for discrimination between Child-Pugh A group and Child-Pugh B+C group. Among all patients, there was no significant correlation between REHBP, skewness and ICG R15 (P＞0.05). The minimum, 5th, 10th, 15th, 20th percentile and 0.025th quantile were negatively correlated with ICG R15 (r=-0.274 to -0.300, P＜0.05). In the group of ICG R15≥10%, REHBP, skewness, 5th, 10th percentile and 0.025th percentile were negatively correlated with ICG R15 (r=-0.390 to -0.594, P＜0.05), while in the group of ICG R15＜10%, no significant correlations were found between all parameters and ICG R15 (r=-0.027 to 0.153, P＞0.05).Conclusions The REHBP and histogram parameters at hepatobiliary phase of Gd-EOB-DTPA enhanced MRI may assess the liver reserve function. Compared to REHBP, the histogram parameters have higher correlation with ICG R15.
[Keywords] hepatic reserve function；indocyanine green；gadolinium-ethoxybenzyl diethylenetriamine pentaacetic acid；histogram analysis；magnetic resonance imaging

LIAN Yuqing1   XUE Xing1   FENG Zhan1   ZHENG Yan2   CHEN Feng1*  

1 Department of Radiology, the First Affiliated Hospital of Medical College of Zhejiang University, Hangzhou 310003, China

2 Department of Hepatobiliary surgery, the First Affiliated Hospital of Medical College of Zhejiang University, Hangzhou 310003, China

Chen F, E-mail: chenfenghz@zju.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS Public Fundamental Welfare Projects of Zhejiang Province (No.LSD19H180003).
Received  2021-05-07
Accepted  2021-07-02
DOI: 10.12015/issn.1674-8034.2021.10.008
Cite this article as: Lian YQ, Xue X, Feng Z, et al. Gd-EOB-DTPA-enhanced MRI for evaluation of hepatic reserve function：The value of hepatic signal intensity and histogram in hepatobiliary phase[J]. Chin J Magn Reson Imaging, 2021, 12(10): 36-40. DOI:10.12015/issn.1674-8034.2021.10.008.

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