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Study on the identification of schizophrenia patients with abnormal amplitude of resting low frequency oscillation
CAI Qiuyi  CHEN Yucan  LI Jianlin  ZHAO Zhengkai  WANG Yan 

Cite this article as: Cai QY, Chen YC, Li JL, et al. Study on the identification of schizophrenia patients with abnormal amplitude of resting low frequency oscillation[J]. Chin J Magn Reson Imaging, 2021, 12(10): 45-48. DOI:10.12015/issn.1674-8034.2021.10.010.


[Abstract] Objective To study the changes of brain function in patients with schizophrenia by using amplitude of low-frequency fluctuation (ALFF) index in resting-state functional magnetic resonance imaging (rs-fMRI). Materials andMethods Seventy-two schizophrenic patients and 75 normal controls were enrolled to analyze the difference of ALFF between the two groups. The machine learning algorithm was conducted to select the altered ALFF that could effectively identify schizophrenia patients with healthy controls.Results Patients with schizophrenia showed increased ALFF in the right fusiform gyrus, left inferior temporal gyrus and left medial superior frontal gyrus as well as decreased ALFF in left thalamus and right posterior central gyrus (GRF corrected, voxel P＜0.001, cluster P＜0.05). The altered ALFF in resting state could identify patients with schizophrenia.Conclusions Patients with schizophrenia have abnormal spontaneous brain activity compared with normal controls, which may be the candidate neurobiological markers of patients with schizophrenia.
[Keywords] schizophrenia；resting state；functional magnetic resonance imaging；amplitude of low-frequency amplitude；machine learning

CAI Qiuyi   CHEN Yucan*   LI Jianlin   ZHAO Zhengkai   WANG Yan  

Department of Radiology, Chengdu Third People's Hospital, Chengdu 610000, China

Chen YC, E-mail: miracle0833@163.com

Conflicts of interest   None.

Received  2021-04-08
Accepted  2021-07-06
DOI: 10.12015/issn.1674-8034.2021.10.010
Cite this article as: Cai QY, Chen YC, Li JL, et al. Study on the identification of schizophrenia patients with abnormal amplitude of resting low frequency oscillation[J]. Chin J Magn Reson Imaging, 2021, 12(10): 45-48. DOI:10.12015/issn.1674-8034.2021.10.010.

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