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The value of Gd-EOB-DTPA-enhanced MRI nomogram model in predicting microvascular invasion of small solitary hepatocellular carcinoma
TIAN Yaqi  HU Yabin  PENG Qiqi  SU Xiaohui  WANG Xiaolin  CHEN Jingjing 

Cite this article as: Tian YQ, Hu YB, Peng QQ, et al. The value of Gd-EOB-DTPA-enhanced MRI nomogram model in predicting microvascular invasion of small solitary hepatocellular carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(10): 57-60, 65. DOI:10.12015/issn.1674-8034.2021.10.013.


[Abstract] Objective To explore the value of the nomogram based on gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced MRI of the microvascular invasion (MVI) in small solitary hepatocellular carcinoma (≤3 cm). Materials andMethods In this study, we retrospectively analyzed 149 patients with small solitary hepatocellular carcinoma (≤3 cm) who underwent preoperative Gd-EOB-DTPA-enhanced MRI between January 2017 and June 2020. All patients were grouped into MVI-negative and MVI-positive cases according to the histopathological diagnosis. Then, preoperative clinical, Gd-EOB-DTPA-enhanced MRI and pathological data were collected. Univariate and multivariate Logistic regression analyses were used to analyze the relevant risk factors for MVI, and then a nomogram incorporated preoperative data was developed by multivariate Logistic regression. Finally, the prediction efficiency of the model is evaluated.Results Analysis of the MVI-positive group (45 cases) and the MVI-negative group (104 cases) showed peritumoral hypointensity on HBP (OR=5.951, 95% CI: 2.303—15.372, P＜0.001), peritumor enhancement (OR=3.834, 95% CI: 1.301—11.299, P=0.015), peritumoral pseudocapsule incomplete (OR=9.721, 95% CI: 2.486—38.019, P=0.001), the lower ADC values (＜0.990×10-3 mm2/s) were independent predictors of MVI of small solitary hepatocellular carcinoma. The area under the ROC curve was 0.844. A nomogram showed that peritumoral hypointensity on HBP was the largest contributing factor (100 points) in predicting MVI of small solitary hepatocellular carcinoma, and the others were peritumor enhancement, peritumoral pseudocapsule incomplete and lower ADC values. The C-index of the nomogram was 0.844, and the model was highly predictive of MVI.Conclusions A nomogram of Gd-EOB-DTPA-enhanced MRI can effectively predict microvascular invasion of solitary small hepatocellular carcinoma.
[Keywords] hepatocellular carcinoma；microvascular invasion；Gd-EOB-DTPA；magnetic resonance imaging；nomogram

TIAN Yaqi1, 2   HU Yabin2   PENG Qiqi1, 2   SU Xiaohui2   WANG Xiaolin1, 2   CHEN Jingjing2*  

1 School of Medicine, Qingdao University, Qingdao 266100, China

2 Department of Radiology, Affiliated Hospital of Qingdao University, Qingdao 266016, China

Chen JJ, E-mail: chenjingjingsky@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Qingdao Science and Technology Project (17-3-3-22-nsh).
Received  2021-02-22
Accepted  2021-07-05
DOI: 10.12015/issn.1674-8034.2021.10.013
Cite this article as: Tian YQ, Hu YB, Peng QQ, et al. The value of Gd-EOB-DTPA-enhanced MRI nomogram model in predicting microvascular invasion of small solitary hepatocellular carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(10): 57-60, 65. DOI:10.12015/issn.1674-8034.2021.10.013.

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