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Evaluation of Her-2 gene expression in endometrial carcinoma by amide proton transfer weighted and fat quantitative
TIAN Shifeng  LIU Ailian  REN Xue  CHEN Lihua  WANG Nan  LIN Liangjie  WANG Jiazheng  ZHANG Yi  ZHANG Ting 

Cite this article as: Tian SF, Liu AL, Ren X, et al. Evaluation of Her-2 gene expression in endometrial carcinoma by amide proton transfer weighted and fat quantitative[J]. Chin J Magn Reson Imaging, 2021, 12(11): 70-73. DOI:10.12015/issn.1674-8034.2021.11.015.


[Abstract] Objective To explore the value of amide proton transfer weighted (APTw) imaging and fat quantitative measurement (mDIXON-Quant) techniques in evaluating the expression of human epidermal growth factor receptor-2 (Her-2) gene in endometrial carcinoma (EC).Materials and Methods: The data of 26 patients with EC confirmed by operation and pathology were retrospectively analyzed, including 11 cases in Her-2 positive group and 15 cases in Her-2 negative group. 3.0 T MR examination was performed before operation. The scanning sequence included APTw and mDIXON-Quant. After scanning, the APT map of APTw sequence and R2* map, fat fraction (FF) map of mDIXON-Quant sequence were obtained by post-processing. The values of APT, R2* and FF of the two groups were measured by two observers respectively. Intra-class correlation coefficients (ICC) was used to test the consistency of the two observers' measurement results of the parameters of the two groups. The differences of each parameter value of the two groups were compared by using the independent sample t test or Mann Whitney U test. ROC curve was used to evaluate the efficiency of the parameters with statistical difference evaluating the expression of Her-2 gene in EC. Area under the curve (AUC), corresponding cut-off value, sensitivity and specificity were calculated.Results The data measured by two observers were consistent (ICC＞0.75).The values of APT, R2* and FF in the Her-2 positive group were 2.850% (2.300%, 2.900%)、(17.102±2.333) Hz and 1.629%±1.086%, respectively. The above parameters were 2.313%±0.415%、(15.134±1.854) Hz and 1.476%±1.131% respectively in the Her-2 negative group. The APT, R2* values of Her-2 positive group were higher than those in the Her-2 negative group, the difference was statistically significant (P＜0.05). There was no statistically significant difference in FF values between the two groups (P＞0.05). The AUC of APT, R2* values in evaluating the expression of Her-2 gene in EC were 0.755 and 0.739, the cutoff value were 2.475% and 16.503 Hz, the sensitivity were 72.7% and 63.6%, the specificity were 80.0% and 86.7%, respectively.Conclusions APTw and mDIXON-Quant have the potential to evaluate the expression of EC Her-2 gene half quantitatively, and have certain clinical application value.
[Keywords] endometrial carcinoma；human epidermal growth factor receptor-2；magnetic resonance imaging；amide proton transferweighted；fat quantitative；prediction

TIAN Shifeng1, 2   LIU Ailian1, 2*   REN Xue1, 2   CHEN Lihua1, 2   WANG Nan1, 2   LIN Liangjie3   WANG Jiazheng3   ZHANG Yi4   ZHANG Ting1, 2  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

2 Dalian Medical Imaging artificial intelligence engineering technology research center, Dalian 116011, China

3 Philips (China) Investment Co., Ltd, Shanghai 200040, China

4 Key Laboratory for Biomedical Engineering of Ministry of Education, Department of Biomedical Engineering, College of Biomedical Engineering & Instrument Science, Zhejiang University, Hangzhou 310012, China

Liu AL, E-mail: liuailian@dmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS Dalian Horizontal Topic "Application value of compressed sensing in the whole body" (No. 2021-01).
Received  2021-06-17
Accepted  2021-08-27
DOI: 10.12015/issn.1674-8034.2021.11.015
Cite this article as: Tian SF, Liu AL, Ren X, et al. Evaluation of Her-2 gene expression in endometrial carcinoma by amide proton transfer weighted and fat quantitative[J]. Chin J Magn Reson Imaging, 2021, 12(11): 70-73. DOI:10.12015/issn.1674-8034.2021.11.015.

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