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• Clinical Article •
The value of Gd-EOB-DTPA enhanced magnetic resonance imaging for predicting early recurrence of hepatocellular carcinoma after resection
ZHAO Qiyu  QI Yuangang  GUO Shoufang  ZHANG Hong  LIU Qianqian  CHEN Yingxiu  JI Huijun  LI Wanhu 

Cite this article as: Zhao QY, Qi YG, Guo SF, et al. The value of Gd-EOB-DTPA enhanced magnetic resonance imaging for predicting early recurrence of hepatocellular carcinoma after resection[J]. Chin J Magn Reson Imaging, 2021, 12(12): 18-23. DOI:10.12015/issn.1674-8034.2021.12.004.


[Abstract] Objective To evaluate the predictive value of preoperative Gd-EOB-DTPA enhanced MRI in early recurrence (ER) of hepatocellular carcinoma (HCC) after radical resection. Materials and Methods: The data of patients who underwent radical resection of hepatocellular carcinoma in Shandong Cancer Hospital from January 2016 to May 2020 were retrospectively analyzed. A total of 68 patients who underwent Gd-EOB-DTPA enhanced MRI before resection were included. Among them, 18 cases had early recurrence within 1 year of postoperative follow-up as ER group, and 50 cases without early recurrence as control group. The clinical and imaging data of the two groups were collected, and the differences of clinical data and preoperative MRI signs between the ER group and the control group were compared. The predictive factors of early recurrence after HCC were analyzed by multivariate Logistic regression, and the predictive model was constructed according to the analysis results. The receiver operating characteristic (ROC) curve was drawn, and analyze the prediction value of the prediction model.Results The parameter of lesion-to-liver contrast enhancement ratio (LLCER) can predict the pathological grade of HCC (P=0.023). The results of comparison between the ER group and the control group showed that there were significant differences in pathological grade, lesion morphology, peritumoral low signal intensity in hepatobiliary phase (HBP), satellite nodules and LLCER between the two groups (P＜0.05). The parameter LLCER in the ER group was lower than that in the control group. Logistic regression analysis showed that HBP peritumoral low signal intensity (OR=7.214, 95% CI=1.230—42.312), satellite nodules (OR=9.198, 95% CI=1.402—60.339) and parameter LLCER value (OR=0.906, 95% CI=0.826—0.995) were independent predictors of early recurrence of hepatocellular carcinoma after resection. According to the analysis results, a prediction model was constructed, and then the predictive value of the model was evaluated by ROC curve. The results showed that the area under ROC curve (AUC) is 0.94, 95% CI=0.883—0.997, sensitivity and specificity of the model for predicting postoperative recurrence of HCC were 0.889 and 0.840 respectively.Conclusions Preoperative Gd-EOB-DTPA enhanced MRI has a certain predictive value for early recurrence after radical resection of hepatocellular carcinoma.
[Keywords] hepatocellular carcinoma；early recurrence；gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid；magnetic resonance imaging；prediction

ZHAO Qiyu1   QI Yuangang1   GUO Shoufang1   ZHANG Hong1   LIU Qianqian2   CHEN Yingxiu2   JI Huijun2   LI Wanhu1*  

1 Department of Radiology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117

2 Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117

Li WH, E-mail: lwhvzg@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Shandong Medical and Health Science and Technology Development Plan Project (No.2019WS200); Clinical Research and Cultivation Project of Shandong Cancer Hospital (No. 2020-19).
Received  2021-07-08
Accepted  2021-10-12
DOI: 10.12015/issn.1674-8034.2021.12.004
Cite this article as: Zhao QY, Qi YG, Guo SF, et al. The value of Gd-EOB-DTPA enhanced magnetic resonance imaging for predicting early recurrence of hepatocellular carcinoma after resection[J]. Chin J Magn Reson Imaging, 2021, 12(12): 18-23. DOI:10.12015/issn.1674-8034.2021.12.004.

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