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• Clinical Article •
Multiparametric magnetic resonance imaging to characterize pathological grading and stage of cervical squamous cell carcinoma
LIU Jiren  XU Yi  GUO Limei  SI Peng  GUO Juan 

Cite this article as: Liu JR, Xu Y, Guo LM, et al. Multiparametric magnetic resonance imaging to characterize pathological grading and stage of cervical squamous cell carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(12): 29-33. DOI:10.12015/issn.1674-8034.2021.12.006.


[Abstract] Objective To investigate the value of quantitative parameters derived from T1 mapping, diffusion weighted imaging (DWI) and dynamic contrast enhanced magnetic resonance imaging (DCE-MRI) in pathologically grading and staging of cervical squamous cell carcinoma (CSCC). Materials and Methods: A total of 65 patients with pathology confirmed CSCC were enrolled in this study, including 11 cases of well differentiated, 32 cases of moderately differentiated, 22 case of poorly differentiated, and 37 case of early-stage (FIGO ⅠB-ⅡA), 28 case of late-stage (FIGO ⅡB-Ⅳ). Patients underwent pretreatment T1 mapping, DWI and DCE-MRI scan and T1, ADC, Ktrans and Kep values of tumor tissues were obtained. One-way ANOVA was used to compare the differences of quantitative parameters among different pathological grades. The independent sample t test was used to assess the difference between the early- and late-stage group. ROC curves analysis was performed to determine the diagnostic efficacy of quantitative parameters.Results T1, ADC and Ktrans values were significant difference in different pathological grade of CSCC (P＜0.05). In term of distinguishing early-from late-stage, T1 value in the early-stage CSCC was higher, and Ktrans values was lower than the late-stage CSCC. The differences were significant (P＜0.05). The area under ROC curve (AUC) of T1, ADC and Ktrans values in the diagnosis of poorly differentiated CSCC were 0.83, 0.74 and 0.79, respectively. A combination of these quantitative parameters showed the highest diagnostic efficiency with an AUC of 0.91. The AUC of T1 and Ktrans values in the diagnosis of early stage CSCC was 0.67 and 0.65, respectively, and a combination of T1 and Ktrans achieved an AUC of 0.69.Conclusion T1 mapping, DWI and DCE-MRI quantitative parameters can be used as predictors to evaluate the pathological grade and staging of CSCC. The combination of multiple parameters can improve the diagnostic sensitivity of cervical squamous cell carcinoma, which has high clinical application value.
[Keywords] cervical squamous cell carcinoma；magnetic resonance imaging；longitudinal relaxation time；diffusion-weighted imaging；dynamic contrast enhanced imaging

LIU Jiren1   XU Yi2   GUO Limei2   SI Peng3   GUO Juan3*  

1 Department of Cancer Center, Third Hospital of Shanxi Medical University (Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences), Taiyuan 030032, China

2 Department of Radiology, Second Hospital of Shanxi Medical School, Taiyuan 030001, China

3 Department of Medical Imaging Center, Third Hospital of Shanxi Medical University (Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences), Taiyuan 030032, China

Guo J, E-mail: 13934110426@163.com

Conflicts of interest   None.

Received  2021-08-09
Accepted  2021-11-05
DOI: 10.12015/issn.1674-8034.2021.12.006
Cite this article as: Liu JR, Xu Y, Guo LM, et al. Multiparametric magnetic resonance imaging to characterize pathological grading and stage of cervical squamous cell carcinoma[J]. Chin J Magn Reson Imaging, 2021, 12(12): 29-33. DOI:10.12015/issn.1674-8034.2021.12.006.

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