Share：
Share this content in WeChat
X
[Chinese][PDF]67374
• Experience Exchanges •
Preliminary study on the application value of 3.0 T magnetic resonance amide proton transfer (APT) imaging in breast diseases
WEN Jie  WANG Meng  XIANG Lu  LIU Zhou  REN Ya  YANG Qian  LUO Dehong 

Cite this article as: Wen J, Wang M, Xiang L, et al. Preliminary study on the application value of 3.0 T magnetic resonance amide proton transfer (APT) imaging in breast diseases[J]. Chin J Magn Reson Imaging, 2021, 12(12): 67-70. DOI:10.12015/issn.1674-8034.2021.12.013.


[Abstract] Objective To investigate the application value of 3.0 T magnetic resonance amide proton transfer (APT) imaging in breast diseases. Materials and Methods: In this retrospective study, 81 cases with pathological confirmed breast diseases in Nation Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital from January 2020 to December 2020 were enrolled. The baseline preoperative APT images and clinical-pathological data were collected and analyzed. In total, there were 81 patients with 81 lesions, including 56 malignant breast lesions and 25 benign breast lesions, between which the differences of APT values were compared. Also, the APT values of breast cancer with different lymph node metastasis status, estrogen receptor, progesterone receptor, human epidermal growth factor receptor 2 and Ki-67 expression were compared.Results There was significant difference in the mean APT values among malignant lesion, benign lesion and normal breast tissues (P＜0.01). Both breast cancer lesions (1.781±1.103)% and benign breast lesions (1.756±0.752)% had significantly higher mean APT values than that of the corresponding contralateral normal gland tissue (0.868±0.565)% and (1.101±0.372)% (all P＜0.01). However, there was no significant difference in the mean APT value between malignant and benign breast lesions (P=0.917). The APT value of breast cancer in high Ki-67 expression group (2.073±1.278)% was higher than that of the low Ki-67 expression group (1.362±0.592)% (P＜0.05). The APT value of low breast cancer infiltrating grade (gradeⅠandⅡ) was 1.163 (0.833)%, which was significantly lower than that of grade Ⅲ 1.675 (0.887)%. There was no significant difference in APT value between lymph node metastasis group and non-metastasis group, ER positive group and negative group, PR positive group and negative group, Her-2 positive group and negative group (all P＞0.05).Conclusion Benign and malignant breast lesions have significantly higher APT effect than normal tissues, which proves the feasibility of using APT to evaluate breast lesions. Moreover, preliminary studies have shown that the APT effect can reflect the degree of breast cancer invasion and cell proliferation index, suggesting that APT imaging can potentially be used to predict the prognosis of breast cancer.
[Keywords] magnetic resonance imaging；amide proton transfer imaging；breast cancer；benign breast lesions；normal breast tissue

WEN Jie1   WANG Meng1   XIANG Lu1   LIU Zhou1   REN Ya1   YANG Qian1   LUO Dehong1, 2*  

1 Nation Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518000, China

2 Nation Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Mediacal Sciences and Peking Union Medical College, Beijing 100021, China

Luo DH, E-mail: cjr.luodehong@vip.163.com

Conflicts of interest   None.

志谢 感谢GE公司磁共振科研团队钱龙博士提供的技术支持。
Received  2021-06-25
Accepted  2021-11-15
DOI: 10.12015/issn.1674-8034.2021.12.013
Cite this article as: Wen J, Wang M, Xiang L, et al. Preliminary study on the application value of 3.0 T magnetic resonance amide proton transfer (APT) imaging in breast diseases[J]. Chin J Magn Reson Imaging, 2021, 12(12): 67-70. DOI:10.12015/issn.1674-8034.2021.12.013.

[1]
Ward KM, Aletras AH, Balaban RS. A new class of contrast agents for MRI based on proton chemical exchange dependent saturation transfer (CEST)[J]. J Magn Reson, 2000, 143(1): 79-87. DOI: 10.1006/jmre.1999.1956.
[2]
Zhou J, Payen JF, Wilson DA, et a1. Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI[J]. Nat Med, 2003, 9(8): 1085-1090. DOI: 10.1038/nm907.
[3]
Yu L, Li CM, Luo XJ, et al. Differentiation of Malignant and Benign Head and Neck Tumors with Amide Proton Transfer-Weighted MR Imaging[J]. Mol Imaging Biol, 2019, 21(2): 348-355. DOI: 10.1007/s11307-018-1248-1.
[4]
Zu Z, Li H, Xu J, et al. Measurement of APT using a Combined CERT-AREX Approach with Varying Duty Cycles[J]. Magn Reson Imaging, 2017, 10(42): 22-31. DOI: 10.1016/j.mri.2017.05.001.
[5]
Lee DH, Heo HY, Zhang K, et al. Quantitative assessment of the effects of water proton concentration and water T1 changes on amide proton transfer (APT) and nuclear overhauser enhancement (NOE) MRI: The origin of the APT imaging signal in brain tumor[J]. Magn Reson Med, 2017, 77(2): 855-863. DOI: 10.1002/mrm.26131.
[6]
Yang YL, Huang B. Differentiating pseudoprogression from recurrence in patients with gliomas using amide proton transfer imaging[J]. Int Rev Neurobiol, 2019, 42(5): 535-538. DOI: 10.19300/j.2019.Z6946.
[7]
Sun SY, Liu YF, Ding YY, et al. Progress in the application of amide proton transfer imaging in glioma[J]. Chin J Radiol, 2019, 53(8): 714-716. DOI: 10.3760/cma.j.issn.1005-1201.2019.08.017.
[8]
Wang KW, Wu RH, Zhang MM. Preliminary study of breast cancer in magnetic resonance imaging based on amide proton transfer[J]. Funct Mol Med Imaging (Electronic Edition), 2013, 2(1): 41-46. DOI: 10.3969/j.issn.2095-2252.2013.01.008.
[9]
Klomp DWJ, Dula AN, Arlinghaus LR, et al. Amide Proton Transfer Imaging of the Human Breast at 7 Tesla: Development and Reproducibility[J]. NMR Biomed. 2013, 26(10): 1271-1277. DOI: 10.1002/nbm.2947.
[10]
Dula AN, Dewey BE, Arlinghaus LR, et al. Optimization of 7-T chemical exchange saturation transfer parameters for validation of glycosaminoglycan and amide proton transfer of fibroglandular breast tissue[J]. Radiology, 2015, 275(1): 255-261. DOI: 10.1148/radiol.14140762.
[11]
Yang Q, Zou LY, Liu Z, et al. Preliminary application of amide proton transfer-MRI in diagnosis of nasopharyngeal carcinomas[J]. Chin J Magn Reson Imaging, 2021, 12(9): 6-10. DOI: 10.12015/issn.1674-8034.2021.09.002.
[12]
Kamitani T, Sagiyama K, Togao O, et al. Amide proton transfer (APT) imaging of parotid tumors: Differentiation of malignant and benign tumors[J]. Eur J Radiol, 2020, 129: 109047. DOI: 10.1016/j.ejrad.2020.109047.
[13]
Ye YF, Xu ZW, Zeng WH, et al. The value of amide proton transfer imaging in predicting the effect of nasopharyngeal carcinoma after chemoradiotherapy. Chin J Magn Reson Imaging, 2020, 11(8): 635-640. DOI: 10.12015/issn.1674-8034.2020.08.008.
[14]
Curigliano G, Burstein HJ, Winter EP, et al. De-escalating and escalating treatments for early-stage breast cancer:the St.Gallen International Expert Consensus Conference on the Primary Therapy of Early Breast Cancer 2017[J]. Ann Oncol, 2017, 28(8): 1700-1712. DOI: 10.1093/annonc/mdx308.
[15]
Chen ZL, Han Z, Liu GS. Repurposing Clinical Agents for Chemical Exchange Saturation Transfer Magnetic Resonance Imaging: Current Status and Future Perspectives[J]. Pharmaceuticals, 2020, 14(1): 11. DOI: 10.3390/ph14010011.
[16]
Zhou J, Yan K, Zhu H. A Simple Model for Understanding the Origin of the Amide Proton Transfer MRI Signal in Tissue[J]. Appl Magn Reson, 2012, 42(3): 393-402. DOI: 10.1007/s00723-011-0306-5.
[17]
Wang XJ, Wang J, Liu WL, et al. Amide proton transfer-weighted imaging and diffusion weighted imaging in differential diagnosis of benign and malignant breast lesions[J]. Chin J Med Imaging Technol, 2020, 36(12): 1820-1824. DOI: 10.13929/j.issn.1003-3289.2020.12.013.
[18]
Wu B, Jia F, Li X, et al. Comparative Study of Amide Proton Transfer Imaging and Intravoxel Incoherent Motion Imaging for Predicting Histologic Grade of Hepatocellular Carcinoma[J]. Front Oncol, 2020, 10: 562049. DOI: 10.3389/fonc.2020.562049.
[19]
Li B, Sun H, Zhang S, et al. Amide proton transfer imaging to evaluate the grading of squamous cell carcinoma of the cervix: A comparative study using 18F FDG PET[J]. J Magn Reson Imag, 2019, 50(1): 261-268. DOI: 10.1002/jmri.26572.
[20]
Jiang S, Eberhart CG, Zhang Y, et al. Amide proton transfer-weighted magnetic resonance image-guided stereotactic biopsy in patients with newly diagnosed gliomas[J]. Eur J Cancer, 2017, 83: 9-18. DOI: 10.1016/j.ejca.2017.06.009.

PREV The effect of fast scan parameters on evaluation of T1, T2 relaxation times and proton density of normal brain using synthetic MRI
NEXT Value of 3.0 T dynamic contrast-enhanced MRI of breast combined with mammography in the differential diagnosis of benign and malignant small breast nodules with diameter ≤≤2 cm
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn