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Value of 3.0 T dynamic contrast-enhanced MRI of breast combined with mammography in the differential diagnosis of benign and malignant small breast nodules with diameter ≤2 cm
XIE Fuyou  QIU Xiaohui  LIU Yichao  WANG Li  SHI Zhenshan  LIU Bin 

Cite this article as: Xie FY, Qiu XH, Liu YC, et al. Value of 3.0 T dynamic contrast-enhanced MRI of breast combined with mammography in the differential diagnosis of benign and malignant small breast nodules with diameter≤2 cm[J]. Chin J Magn Reson Imaging, 2021, 12(12): 71-74. DOI:10.12015/issn.1674-8034.2021.12.014.


[Abstract] Objective To evaluate the imaging characteristics and diagnostic value of 3.0 T dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) of breast combined with mammography on small breast nodules with diameter≤2 cm. Materials and Methods: A retrospective analysis was performed on the clinical data of 135 patients with small breast nodules with diameter≤2 cm who were admitted between January 2018 and September 2020. All patients were confirmed by surgical pathology or tissue biopsy, and they performed mammography and DCE-MRI examination before surgery. The morphological characteristics, time-signal intensity curve (TIC) classification, TIC maximum signal intensity value (SImax), peak height (PH), maximum linear slope (Slope) and Slope ratio (SlopeR) of breast cancer and benign lesions were analyzed under DCE-MRI examination. Taking pathological examination results as the gold standard, mammography diagnosis results were combined to explore the diagnostic value of DCE-MRI on small breast cancer with diameter≤2 cm.Results There were statistical differences in the morphological characteristics of DCE-MRI margin and internal enhancement and TIC classification and early enhancement rate between breast cancer group and benign group (P＜0.05), and the proportions of marginal burr sign, internal uneven enhancement, TIC classification of type Ⅲ and early enhancement rate≥60% were 73.49%, 59.04%, 75.90% and 83.13% in breast cancer group and were 3.85%, 34.62%, 7.69% and 28.85% in benign group. The Slope and SlopeR value in breast cancer group was significantly higher than those in benign group (P＜0.05). Taking pathological diagnosis results as the gold standard, the sensitivity, specificity, accuracy rate and Kappa value with pathological diagnosis of DCE-MRI in diagnosing breast cancer with diameter≤2 cm were 0.964, 0.904, 0.941 and 0.874 respectively, which were better than 0.832, 0.885, 0.852 and 0.696 of mammography, and the corresponding values of the combined diagnosis of the two were 0.988, 0.860, 0.940 and 0.869 respectively.Conclusions The benign and malignant lesions of small breast nodules under DCE-MRI are significantly different in morphology, TIC classification and related parameters. The diagnostic efficacy of DCE-MRI on small breast cancer with diameter≤2 cm is better than that of mammography, and the combination of the two has higher diagnostic value.
[Keywords] small breast cancer；magnetic resonance imaging；dynamic contrast-enhanced；mammography；differential diagnosis

XIE Fuyou1, 2   QIU Xiaohui2   LIU Yichao2   WANG Li2   SHI Zhenshan2   LIU Bin1*  

1 Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

2 Imaging Center, Bozhou Hospital Affiliated to Anhui Medical University, Bozhou 236800, China

Liu B, E-mail: lbhyz321@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS China International Medical Foundation Project (Z-2014-06-18388).
Received  2021-05-12
Accepted  2021-09-08
DOI: 10.12015/issn.1674-8034.2021.12.014
Cite this article as: Xie FY, Qiu XH, Liu YC, et al. Value of 3.0 T dynamic contrast-enhanced MRI of breast combined with mammography in the differential diagnosis of benign and malignant small breast nodules with diameter≤2 cm[J]. Chin J Magn Reson Imaging, 2021, 12(12): 71-74. DOI:10.12015/issn.1674-8034.2021.12.014.

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