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The value of IVIM-DWI combined with Gd-EOB-DTPA enhanced MRI in prediction of hepatocellular carcinoma microvascular invasion
LI Xiaofeng  ZHUANG Yuxiang  ZHOU Xinjie  ZHOU Daiquan  KUANG Lianqin  ZENG Yan 

Cite this article as: Li XF, Zhuang YX, Zhou XJ, et al. The value of IVIM-DWI combined with Gd-EOB-DTPA enhanced MRI in prediction of hepatocellular carcinoma microvascular invasion[J]. Chin J Magn Reson Imaging, 2021, 12(12): 75-78, 88. DOI:10.12015/issn.1674-8034.2021.12.015.


[Abstract] Objective To explore the predictive value of intravoxel incoherent motion diffusion weighted imaging (IVIM-DWI) combined with Gd-EOB-DTPA enhanced MRI images for hepatocellular carcinoma (HCC) microvascular invasion (MVI). Materials and Methods: The MRI images and clinical data of 57 patients with HCC confirmed by pathology were analyzed retrospectively. Standard ADC value, D value, D* value, f value, relative enhancement (RE) rate and imaging characteristics were analyzed. Chi-square test, t test, and U test were used in the comparison between groups. Multivariate logistic regression analysis was performed on the variables with differences. ROC curves were used to compare the diagnostic efficacy of predicting significant indicators of MVI.Results There were significant differences in tumor size, margin, peritumor enhancement in arterial phase and D value between MVI positive group and negative group (P＜0.05), among which D value had the best diagnostic efficacy (AUC 0.849, sensitivity 75.0% and specificity 81.1%). Multivariate Logistic regression analysis showed that tumor size, arterial peritumor enhancement and D value were independent risk factors for MVI. ROC curve analysis showed that the combination of D value and arterial tumor enhancement had the highest diagnostic efficacy in predicting MVI (AUC 0.879, sensitivity 86.5% and specificity 80.0%).Conclusions The combination of D value and arterial periodical enhancement can improve the accuracy of predicting MVI. The smaller the D value is, the more likely the HCC with periodical enhancement is to have MVI.
[Keywords] hepatocellular carcinoma；microvascular invasion；magnetic resonance imaging；diffusion weighted imaging；Gd-EOB-DTPA

LI Xiaofeng   ZHUANG Yuxiang   ZHOU Xinjie   ZHOU Daiquan   KUANG Lianqin   ZENG Yan*  

Department of Radiology, the Third Affiliated Hospital of Chongqing Medical University, Chongqing 401120

Zeng Y, E-mail: zengyan@cqmu.edu.cn

Conflicts of interest   None.

Received  2021-06-03
Accepted  2021-07-12
DOI: 10.12015/issn.1674-8034.2021.12.015
Cite this article as: Li XF, Zhuang YX, Zhou XJ, et al. The value of IVIM-DWI combined with Gd-EOB-DTPA enhanced MRI in prediction of hepatocellular carcinoma microvascular invasion[J]. Chin J Magn Reson Imaging, 2021, 12(12): 75-78, 88. DOI:10.12015/issn.1674-8034.2021.12.015.

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