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• Clinical Article •
The value of multimodal MRI combined with clinical indexes in predicting the short-term effect of neoadjuvant therapy for stage ⅠB1-ⅡA2 cervical cancer
MA Jintao  QIN Fengying  ZHAO Mingli  PANG Huiting  LUO Yahong  DONG Yue 

Cite this article as: Ma JT, Qin FY, Zhao ML, et al. The value of multimodal MRI combined with clinical indexes in predicting the short-term effect of neoadjuvant therapy for stage ⅠB1-ⅡA2 cervical cancer[J]. Chin J Magn Reson Imaging, 2022, 13(1): 59-63, 102. DOI:10.12015/issn.1674-8034.2022.01.012.


[Abstract] Objective To access the value of multimodal MRI combined with clinical indexes to predict the efficacy of neoadjuvant therapy for stage ⅠB1-ⅡA2 cervical cancer.Materials and Methods Sixty-four cases of cervical cancer patient who received neoadjuvant therapy were retrospectively analyzed. According to the treatment response, the patients were divided into significant response group and non-significant response group. The clinical indexes, ADC value and DCE-MRI parameters (Ktrans, Kep, Ve) of the two groups were analyzed and compared. The correlation between clinical and imaging indexes of the two groups and the neoadjuvant therapy effect was analyzed to establish a reliable model for predicting treatment effect.Results Univariate analysis showed that there was no significant difference in age, tumor diameter, clinical stage [International Federation of Gynecology and Obstetrics (FIGO) 2009], squamous carcinoma antigen, pathological type. and neoadjuvant therapy methods between the two groups (P=0.092, 0.500, 0.299, 1.000, 0.101, 0.092), and there was no significant difference in ADC and Ve values between the two groups before treatment (P=0.830, 0.891, 0.853, 0.883, 0.859, 0.170, 0.159, 0.637, 0.404, 0.934). Ktrans and Kep before treatment in the significant response group were higher than those in the non-significant response group (P=0.001, 0.037). Multivariate analysis showed that the predictive model constructed by age, pathological type and the 50th percentile of Kep had the highest diagnostic efficiency, with an AUC of 0.891 (0.812, 0.971), a specificity of 86.3% and a sensitivity of 91.3%.Conclusions MRI parameters combined with clinical indexes have a certain value in predicting short-term efficacy of neoadjuvant therapy for cervical cancer.
[Keywords] cervical cancer；neoadjuvant therapy；curative effect；dynamic contrast enhanced magnetic resonance imaging；diffusion-weighted imaging

MA Jintao   QIN Fengying   ZHAO Mingli   PANG Huiting   LUO Yahong   DONG Yue*  

Department of Radiology, Liaoning Cancer Hospital & Institute, Cancer Hospital of China Medical University, Dalian Medical University Clinical Oncology College, Shenyang 110041, China

Dong Y, E-mail: dyy1026@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Climbing Foundation of National Cancer Center, China (No. NCC201806B011); Medical engineering cross fund of Liaoning Cancer Hospital and Dalian University of technology, China (No. LD202119); The Fundamental Research Funds for the Central Universities.
Received  2021-05-28
Accepted  2021-11-09
DOI: 10.12015/issn.1674-8034.2022.01.012
Cite this article as: Ma JT, Qin FY, Zhao ML, et al. The value of multimodal MRI combined with clinical indexes in predicting the short-term effect of neoadjuvant therapy for stage ⅠB1-ⅡA2 cervical cancer[J]. Chin J Magn Reson Imaging, 2022, 13(1): 59-63, 102. DOI:10.12015/issn.1674-8034.2022.01.012.

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