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• Original Article •
The correlation between brain gray matter volume changes and executive function in patients with end-stage renal disease
FANG Jie  WANG Haibao  QI Xiangming  SI Li  LI Zhihao  LIU Yarui  ZOU Fan 

Cite this article as: Fang J, Wang HB, Qi XM, et al. The correlation between brain gray matter volume changes and executive function in patients with end-stage renal disease[J]. Chin J Magn Reson Imaging, 2022, 13(1): 86-90. DOI:10.12015/issn.1674-8034.2022.01.017.


[Abstract] Objective To investigate the brain gray matter volume changes and its relationship with executive function in patients with end stage renal disease (ESRD) by using voxel-based morphometry (VBM). Materials andMethods Forty-one patients with ESRD (ESRD group) and 41 gender-, age- and education- matched healthy volunteers (normal control group) were performed by 3D-T1WI MRI scans and executive function tests. To calculate the brain gray matter volume of two groups with VBM, the two-sample independent t-test was performed to test the differences of brain gray matter volume between the two groups. Pearson correlation analysis was performed between different brain gray matter volume and executive function test scores in the ESRD group.Results Compared with normal control group, brain regions of the significantly decreased gray matter volume in ESRD group included anterior cingulate gyrus, bilateral middle cingulate gyrus, bilateral insula, left middle frontal gyrus, left transverse temporal gyrus, left hippocampus and left caudate (P＜0.05, FWE corrected). The gray matter volume in anterior cingulate gyrus, left middle cingulate gyrus and left insula were negatively correlated with trail making test A (TMT-A) score (P＜0.05), the gray matter volume in anterior cingulate gyrus, bilateral insula, left middle frontal gyrus, left transverse temporal gyrus and left hippocampus were positively correlated with digit symbol substitution test(DSST) score (P＜0.05).Conclusion There are abnormal gray matter structures in ESRD patients, and the gray matter atrophy in cingulate gyrus, prefrontal lobe and temporal lobe were associated with the degree of executive dysfunction.
[Keywords] end stage renal disease；voxel-based morphometry；executive dysfunction；magnetic resonance imaging；brain structure

FANG Jie1   WANG Haibao1*   QI Xiangming2   SI Li2   LI Zhihao1   LIU Yarui1   ZOU Fan1  

1 Department of Radiology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

2 Department of Nephrology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China

Wang HB, E-mail: wanghaibao916@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Anhui Province (No. 1908085MH245); Natural Science Research Project of Anhui Universities (No. KJ2018A0493).
Received  2021-07-24
Accepted  2021-11-09
DOI: 10.12015/issn.1674-8034.2022.01.017
Cite this article as: Fang J, Wang HB, Qi XM, et al. The correlation between brain gray matter volume changes and executive function in patients with end-stage renal disease[J]. Chin J Magn Reson Imaging, 2022, 13(1): 86-90. DOI:10.12015/issn.1674-8034.2022.01.017.

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