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Functional connectivity of paraventricular thalamus in nocturnal enuresis: a rs-fMRI study
ZHANG Jing  XING Wei  ZHENG Aibin  JIANG Kaihua  GAO Min 

Cite this article as: Zhang J, Xing W, Zheng AB, et al. Functional connectivity of paraventricular thalamus in nocturnal enuresis: a rs-fMRI study[J]. Chin J Magn Reson Imaging, 2022, 13(1): 106-109. DOI:10.12015/issn.1674-8034.2022.01.021.


[Abstract] Objective To find the brain mechanism of awakening disorder and cognitive deficits in children with nocturnal enuresis (NE) by analyzing changes of functional connectivity (FC) between bilateral paraventricular thalamus (PVT) and whole brain voxel.Materials and Methods: In this study, twenty-two children with NE and thirty-three healthy children as the controls were collected. All subjects underwent resting-state functional magnetic resonance imaging (rs-fMRI) scanning. Bilateral PVT were selected as the regions of interest after pretreatment. Voxel-based functional connectivity (voxel-FC) analysis were used to evaluate the differences in brain function between the two groups.Results Compared with the children in normal control group, the left PVT of NE group exhibited lower FC with brainstem (t=-3.76, P＜0.05) and left middle temporal gyrus (t=-4.35, P＜0.05) but higher FC with the left cerebellum crus Ⅰ, Ⅱ (t=4.18, P＜0.05) and the right posterior central gyrus (t=3.90, P＜0.05). The right PVT of NE group exhibited lower FC with the left superior temporal gyrus (t=-3.73, P＜0.05) but higher FC with the right precentral gyrus (t=4.09, P＜0.05).Conclusions The present study revealed that there were spontaneous FC changes in bilateral PVT in children with NE, which maybe one of the mechanisms of central nervous system in the occurrence and development of the awakening disorder and cognitive deficits in children with NE.
[Keywords] nocturnal enuresis；sleep-wake；paraventricular thalamus；resting state functional magnetic resonance imaging

ZHANG Jing1, 2   XING Wei1*   ZHENG Aibin2   JIANG Kaihua2   GAO Min2  

1 Department of Radiology, the Third Affiliated Hospital of Soochow University, Changzhou 213003, China

2 Department of Radiology, Changzhou Children's Hospital Affiliated to Nantong University, Changzhou 213000, China

Xing W, E-mail: suzhxingwei@126.com

Conflicts of interest   None.

ACKNOWLEDGMENTS The 16th Batch of Science and Technology Plan of Changzhou (No. CJ20200070).
Received  2021-08-20
Accepted  2021-12-21
DOI: 10.12015/issn.1674-8034.2022.01.021
Cite this article as: Zhang J, Xing W, Zheng AB, et al. Functional connectivity of paraventricular thalamus in nocturnal enuresis: a rs-fMRI study[J]. Chin J Magn Reson Imaging, 2022, 13(1): 106-109. DOI:10.12015/issn.1674-8034.2022.01.021.

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