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• Original Article •
Brain function study in T2DM comorbidity depression based on resting state degree centrality
LI Zhoule  ZHAO Lianping  HUANG Gang  LIU Ruifang  TIAN Jing  LU Yashan  WEI Jia 

Cite this article as: Li ZL, Zhao LP, Huang G, et al. Brain function study in T2DM comorbidity depression based on resting state degree centrality[J]. Chin J Magn Reson Imaging, 2022, 13(2): 37-41. DOI:10.12015/issn.1674-8034.2022.02.008.


[Abstract] Objective To explore the abnormal patterns of brain functional networks in type 2 diabetes comorbid depression (T2DD) by using Degree Centrality (DC) method of resting state functional magnetic resonance imaging. To further elucidate the neuroimaging mechanisms of T2DD.Materials and Methods Fifty-six T2DD patients, 59 type 2 diabetes mellitus (T2DM) patients without depression and 57 healthy volunteers were prospectively enrolled. The whole brain DC values of the three groups were compared, and the correlation analysis between the DC values of the brain regions with significant differences and clinical variables and cognitive psychological scale was extracted.Results Compared with control group and T2DM without depression group, T2DD group had lower cognitive score, depression score and anxiety score. Compared with the control group, the DC value of the right posterior cingulate gyrus decreased in T2DM without depression group, and the DC value of the right transverse temporal gyrus increased in T2DD group (GRF correction, voxel P＜0.001, cluster P＜0.05), no correlation was found between the DC values of these brain regions and the clinical data and the cognitive psychosocial scale scoring.Conclusions T2DD patients are associated with more severe emotional abnormalities and cognitive impairment. In resting state, abnormal topology of the functional network of the right transverse temporal gyrus may be a potential neuroimaging biological marker of T2DD brain damage.
[Keywords] diabetes mellitus, type 2；depression；comorbidity；functional brain imaging

LI Zhoule1   ZHAO Lianping2*   HUANG Gang2   LIU Ruifang1   TIAN Jing1   LU Yashan2   WEI Jia3  

1 The First Clinical Medical College of Gansu University of Chinese Medicine (Gansu Provincial Hospital), Lanzhou 730000, China

2 Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

3 Department of Functional Division, Gansu Province People Hospital, Lanzhou 730000, China

Zhao LP, E-mail: lianping_zhao007@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81901724, 81860306); Natural Science Foundation of Gansu Province (No. 20JR5RA156, 21JR7RA593); Research project of Gansu Provincial People's Hospital(No. 19SYPYA-2); "Young Scholars in West China" program of The Chinese Academy of Sciences in 2020.
Received  2021-09-01
Accepted  2022-01-24
DOI: 10.12015/issn.1674-8034.2022.02.008
Cite this article as: Li ZL, Zhao LP, Huang G, et al. Brain function study in T2DM comorbidity depression based on resting state degree centrality[J]. Chin J Magn Reson Imaging, 2022, 13(2): 37-41. DOI:10.12015/issn.1674-8034.2022.02.008.

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