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• Original Article •
Study on multi-voxel 1H-MRS in brain of chronic mountain sickness
BAI Xiuxiu  BAO Haihua  HE Xin 

Cite this article as: Bai XX, Bao HH, He X. Study on multi-voxel 1H-MRS in brain of chronic mountain sickness[J]. Chin J Magn Reson Imaging, 2022, 13(2): 42-46. DOI:10.12015/issn.1674-8034.2022.02.009.


[Abstract] Objective Using multi-voxel hydrogen proton magnetic resonance spectroscopy (1H-MRS) to explore the characteristics of brain metabolites in chronic mountain sickness (CMS) under long-term hypoxia, and compare the metabolites with correlations between blood parameters.Materials and Methods Seventeen male patients who were diagnosed with CMS at Qinghai University Affiliated Hospital were collected as the experimental group, with age of (53.29±9.03) years, living altitude of (3989.12±937.45) meters and hemoglobin (HGB) of (224.35±11.81) g/mL. The control group consisted of eighteen healthy volunteers with the same age, gender and living altitude as the experimental group. The living altitude was (3674.94±634.27) meters, and the HGB was (156.67±9.46) g/mL. All cases were examined by routine head MRI and multi-voxel 1H-MRS 3D chemical shift imaging technology (CSI-SLASER) with 20-channel head coil of Siemens Prisma 3.0 T MR scanner. 1H-MRS images were obtained by Syngo.via post-processing software, bilateral frontal lobe and hippocampus were selected as ROIs. The ratios of N-acetylaspartate/creatine (NAA/Cr), choline/creatine (CHo/Cr), N-acetylaspartate/choline (NAA/CHo) and lactic acid/creatine (Lac/Cr) were measured. Then the correlation between the ratio of each metabolite in bilateral frontal lobe, hippocampus and blood biochemical indexes in CMS group was analyzed.Results (1) There was no significant statistical difference in age and living altitude between the two groups (P＞0.05), but the HGB, red blood cell count (RBC) and hematocrit (HCT) in the two groups were significantly higher than those in the control group, while platet (PLT) was lower than those in control group, with significant differences (P＜0.01). (2) Compared with the control group, NAA/Cr and NAA/CHo in bilateral frontal lobe and bilateral hippocampus decreased, Lac/Cr increased in CMS group, which were statistically significant (P＜0.05). (3) Compared with the control group, the CHo/Cr of bilateral frontal lobe and bilateral hippocampus increased (P＞0.05), but there was no statistical significance between the two groups. (4) In CMS group, CHo/Cr in the right frontal lobe and left hippocampus was positively correlated with RBC, CHo/Cr in the left frontal lobe was positively correlated with HCT, Lac/Cr in the right frontal lobe and left hippocampus was positively correlated with HCT.Conclusions Under the long-term hypoxia condition of CMS, local metabolites in brain tissues are changed, neurons are damaged and anaerobic metabolism increased, and the changes of these metabolites are correlated with blood indexes to a certain extent, which can provide imaging evidence and monitoring indicators for further prevention or intervention of brain damage in CMS patients.
[Keywords] hydrogen proton magnetic resonance spectroscopy；chronic mountain sickness；brain；metabolite determination；multi-voxel

BAI Xiuxiu   BAO Haihua*   HE Xin  

Image Center of Affiliated Hospital of Qinghai University, Xining 810000, China

Bao HH, E-mail: baohelen2@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Qinghai Scientific and Technological Achievements Transformation Special Project (No. 2017-SF-158).
Received  2021-10-21
Accepted  2022-01-27
DOI: 10.12015/issn.1674-8034.2022.02.009
Cite this article as: Bai XX, Bao HH, He X. Study on multi-voxel 1H-MRS in brain of chronic mountain sickness[J]. Chin J Magn Reson Imaging, 2022, 13(2): 42-46. DOI:10.12015/issn.1674-8034.2022.02.009.

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