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• Original Article •
Study on thecerebrum metabolism in PI patients using magnetic resonance spectroscopy
SU Xiaoyan  ZHAO Lianping  XIE Yuping  FANG Yanyan  ZHANG Wenwen  ZHOU Liya  HUI Peilin  WANG Xubin 

Cite this article as: Su XY, Zhao LP, Xie YP, et al. Study on thecerebrum metabolism in PI patients using magnetic resonance spectroscopy[J]. Chin J Magn Reson Imaging, 2022, 13(2): 47-51. DOI:10.12015/issn.1674-8034.2022.02.010.


[Abstract] Objective To study the cerebrum metabolism in patients with primary insomnia (PI).Materials and Methods Proton magnetic resonance spectroscopy technology was used to detect concentrations of N-acetyl-aspartate, choline-containing compounds and creatine in the thalamus, hippocampus and putamen of 38 PI patients (PI group) and 39 healthy controls (HC group), and NAA/Cr and Cho/Cr were calculated. Polysomnography (PSG) was used to measure objective sleep parameters. Assess sleep quality by fill in the form of the Pittsburgh sleep quality index and insomnia severity index; Assess sentiment by fill in the form of State-Trait Anxiety Inventory (STAI) and Beck Depression Inventory (BDI).Results (1) Comparison of metabolite concentration: compared with the HC group, the concentration of Cr and Cho in the left thalamus of PI group increased (P=0.040, P=0.007), the concentration of Cho in the right thalamus increased (P=0.039), bilateral hippocampus and shell The metabolites in the nuclear area were not different from the control group (Pall＞0.05). (2) Correlation: The NAA value of the left thalamus in PI patients is negatively correlated with total sleep time and sleep efficiency (r=-0.384, P=0.017), and NAA/Cr value is negatively correlated with REM% (r=-0.387, P=0.016); right thalamus Cho/Cr value is positively correlated with SL% (r=0.380, P=0.019), There was no significant correlation between the thalamus NAA, Cr, Cho, NAA/Cr, Cho/Cr values and the scores of each scale. The Cho value of the left hippocampus of patients with insomnia is positively correlated with ArI (r=0.348, P=0.044); the Cho value of the right hippocampus (r=-0.334, P=0.047), Cr value (r=-0.445, P=0.007) and The BDI score was negatively correlated. The NAA value of the left putamen of PI was positively correlated with N3% (r=0.340, P=0.037); The Cr value of the left putamen is positively correlated with Trait Anxiety Inventory (TAI) (r=0.447, P=0.005); the NAA/Cr value of the left putamen is correlated with N1% (r=-0.344, P=0.047), TAI score (r=-0.521, P=0.001), State Anxiety Inventory (SAI) score (r=-0.400, P=0.013) is negatively correlated; Cho/Cr on the left putamen is negatively correlated with TAI score (r=-0.527, P=0.001) and SAI score (r=-0.434, P=0.007). There was no obvious correlation between the parameters of the differences between the groups and the scores of the various scales and PSG parameters.Conclusion The metabolism of Cho and Cr in the thalamus of PI patients is impaired. Objective sleep affects the metabolism of the thalamus. The patient's mood disorder is related to the metabolism of the hippocampus and putamen.
[Keywords] primary insomnia；proton magnetic resonance spectroscopy；metabolism；thalamus；hippocampus；putamen

SU Xiaoyan1   ZHAO Lianping2   XIE Yuping1*   FANG Yanyan2   ZHANG Wenwen2   ZHOU Liya3   HUI Peilin1   WANG Xubin1  

1 Sleep Medicine Center, Gansu Province Hospital, Lanzhou 730000, China

2 Department of Radiology, Gansu Province Hospital, Lanzhou 730000, China

3 EEG Electromyography Room, Gansu Province Hospital, Lanzhou 730000, China

XieYuping, E-mail: xyp5894@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Found (No. 81560228); Gansu Province Health Industry Scientific Research Plan(No. GSWSKY-2019-88); In-Hospital Scientific Research Fund of Gansu Provincial People's Hospital (No. 21GSSYB-25).
Received  2021-08-11
Accepted  2022-01-30
DOI: 10.12015/issn.1674-8034.2022.02.010
Cite this article as: Su XY, Zhao LP, Xie YP, et al. Study on thecerebrum metabolism in PI patients using magnetic resonance spectroscopy[J]. Chin J Magn Reson Imaging, 2022, 13(2): 47-51. DOI:10.12015/issn.1674-8034.2022.02.010.

[1]
American Psychiatric Association. Zhang DL DOI: . The Diagnostic and Statistical Manual of Mental Disorders-5th Edition[M]. Beijing: Peking University Press, 2014.
[2]
Urbain N, Fourcaud-Trocmé N, Laheux S, et al. Brain-state-dependent modulation of neuronal firing and membrane potential dynamics in the somatosensory thalamus during natural sleep[J]. Cell Rep, 2019, 26(6): 1443-1457.e5. DOI: 10.1016/j.celrep.2019.01.038.
[3]
Xie GJ, Huang XY, Li H, et al. Caffeine-related effects on cognitive performance: roles of apoptosis in rat hippocampus following sleep deprivation[J]. Biochem Biophys Res Commun, 2021, 534: 632-638. DOI: 10.1016/j.bbrc.2020.11.029.
[4]
Boutin A, Pinsard B, Boré A, et al. Transient synchronization of hippocampo-striato-thalamo-cortical networks during sleep spindle oscillations induces motor memory consolidation[J]. NeuroImage, 2018, 169: 419-430. DOI: 10.1016/j.neuroimage.2017.12.066.
[5]
Xie DD, Cheng YX, Tian SY, et al. Structural magnetic resonance imaging of primary insomnia patients & #39; Brian regions[J]. Chin J Med Phys, 2020, 37(11): 1380-1383. DOI: 10.3969/j.issn.1005-202X.2020.11.007.
[6]
Riemann D, Voderholzer U, Spiegelhalder K, et al. Chronic insomnia and MRI-measured hippocampal volumes: a pilot study[J]. Sleep, 2007,30(8): 955-958. DOI: 10.1093/sleep/30.8.955.
[7]
Peng B. A magnetic resonance spectrum imaging study in frontal lobe and Hippocampus of patients with primary insomnia[D]. Guangzhou: Jinan University, 2013.
[8]
Gao H, Yin G Z. Manual for the Scoring of Sleep and Associated Events[M]. Beijing: People's Medical Publishing House, 2018.
[9]
Li C, Ma XF, Dong MS, et al. Abnormal spontaneous regional brain activity in primary insomnia: a resting-state functional magnetic resonance imaging study[J]. Neuropsychiatr Dis Treat, 2016, 12: 1371-1378. DOI: 10.2147/NDT.S109633.
[10]
Endeshaw YW, Yoo W. Association between social and physical activities and insomnia symptoms among community-dwelling older adults[J]. J Aging Health, 2016, 28(6): 1073-1089. DOI: 10.1177/0898264315618921.
[11]
Fortier-Brochu E, Morin CM. Cognitive impairment in individuals with insomnia: clinical significance and correlates[J]. Sleep, 2014, 37(11): 1787-1798. DOI: 10.5665/sleep.4172.
[12]
Li Y, Liu H, Weed JG, et al. Deficits in attention performance are associated with insufficiency of slow-wave sleep in insomnia[J]. Sleep Med, 2016, 24: 124-130. DOI: 10.1016/j.sleep.2016.07.017.
[13]
Benson KL, Bottary R, Schoerning L, et al. 1 H MRS measurement of cortical GABA and glutamate in primary insomnia and major depressive disorder: relationship to sleep quality and depression severity[J]. J Affect Disord, 2020, 274: 624-631. DOI: 10.1016/j.jad.2020.05.026.
[14]
Zhang YC, Zhang ZZ, Wang YL, et al. Dysfunctional beliefs and attitudes about sleep are associated with regional homogeneity of left inferior occidental gyrus in primary insomnia patients: a preliminary resting state functional magnetic resonance imaging study[J]. Sleep Med, 2021, 81: 188-193. DOI: 10.1016/j.sleep.2021.02.039.
[15]
Gong L, Xu RH, Liu D, et al. Abnormal functional connectivity density in patients with major depressive disorder with comorbid insomnia[J]. J Affect Disord, 2020, 266: 417-423. DOI: 10.1016/j.jad.2020.01.088.
[16]
Ji B, Dai M, Guo ZW, et al. Functional connectivity density in the sensorimotor area is associated with sleep latency in patients with primary insomnia[J]. Neuropsychiatr Dis Treat, 2022, 18: 1-10. DOI: 10.2147/ndt.s338489.
[17]
Emamian F, Mahdipour M, Noori K, et al. Alterations of subcortical brain structures in paradoxical and psychophysiological insomnia disorder[J]. Front Psychiatry, 2021, 12: 661286. DOI: 10.3389/fpsyt.2021.661286.
[18]
Morgan PT, Pace-Schott EF, Mason GF, et al. Cortical GABA levels in primary insomnia[J]. Sleep, 2012, 35(6): 807-814. DOI: 10.5665/sleep.1880.
[19]
Plante DT, Jensen JE, Schoerning L, et al. Reduced γ-aminobutyric acid in occipital and anterior cingulate cortices in primary insomnia: a link to major depressive disorder? [J]. Neuropsychopharmacology, 2012, 37(6): 1548-1557. DOI: 10.1038/npp.2012.4.
[20]
Meyerhoff DJ, Mon A, Metzler T, et al. Cortical gamma-aminobutyric acid and glutamate in posttraumatic stress disorder and their relationships to self-reported sleep quality[J]. Sleep, 2014, 37(5): 893-900. DOI: 10.5665/sleep.3654.
[21]
Sarawagi A, Soni ND, Patel AB. Glutamate and GABA homeostasis and neurometabolism in major depressive disorder[J]. Front Psychiatry, 2021, 12: 637863. DOI: 10.3389/fpsyt.2021.637863.
[22]
Ghit A, Assal D, Al-Shami AS, et al. GABA A receptors: structure, function, pharmacology, and related disorders[J]. J Genet Eng Biotechnol, 2021, 19(1): 123. DOI: 10.1186/s43141-021-00224-0.
[23]
Hasegawa H, Selway R, Gnoni V, et al. The subcortical belly of sleep: new possibilities in neuromodulation of basal ganglia? [J]. Sleep Med Rev, 2020, 52: 101317. DOI: 10.1016/j.smrv.2020.101317.
[24]
Javad-Moosavi BZ, Nasehi M, Vaseghi S, et al. Activation and inactivation of nicotinic receptnors in the dorsal hippocampal region restored negative effects of total (TSD) and REM sleep deprivation (RSD) on memory acquisition, locomotor activity and pain perception[J]. Neuroscience, 2020, 433: 200-211. DOI: 10.1016/j.neuroscience.2020.03.006.
[25]
Zarate-Garza PP, Ortega-Balderas JA, de la Barquera JAOS, et al. Hippocampal volume as treatment predictor in antidepressant naïve patients with major depressive disorder[J]. J Psychiatr Res, 2021, 140: 323-328. DOI: 10.1016/j.jpsychires.2021.06.008.
[26]
Yoo D, Lee JY, Kim YK, et al. Mild cognitive impairment and abnormal brain metabolic expression in idiopathic REM sleep behavior disorder[J]. Parkinsonism Relat Disord, 2021, 90: 1-7. DOI: 10.1016/j.parkreldis.2021.07.022.
[27]
Tarun A, Wainstein-Andriano D, Sterpenich V, et al. NREM sleep acid stages specifically alter dynamical integration of large-scale brain networks[J]. iScience, 2020, 24(1): 101923. DOI: 10.1016/j.isci.2020.101923.
[28]
Vasiliadis HM, Lamoureux-Lamarche C, Pitrou I, et al. Sex differences in type of lifetime trauma and suicidal ideation mediated by post-traumatic stress and anxio-depressive disorders in older adults[J]. Int Psychogeriatr, 2020, 32(4): 473-483. DOI: 10.1017/S1041610219001893.

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