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Comparison of value of three MRI perfusion techniques in the preoperative assessment of brain glioma grading
MEI Zou  BI Junying 

Cite this article as: Mei Z, Bi JY. Comparison of value of three MRI perfusion techniques in the preoperative assessment of brain glioma grading[J]. Chin J Magn Reson Imaging, 2022, 13(2): 83-86, 95. DOI:10.12015/issn.1674-8034.2022.02.017.


[Abstract] Objective To analyze the value of three kinds of magnetic resonance imaging (MRI) perfusion techniques of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI), dynamic susceptibility contrast-enhanced perfusion weighted imaging (DSC-PWI) and three-dimensional arterial spin labeling (3D-ASL) in the preoperative assessment of brain glioma (BG) grading.Materials and Methods The clinical data of patients with BG in the hospital were retrospectively analyzed, including 48 cases with preoperative DCE-MRI examination and 34 cases with preoperative DSC-PWI and 3D-ASL examinations. The diagnostic value of DCE-MRI parameters [volume transport constant (Ktrans), rate constant (Kep), extravascular extracellular space fraction (Ve), plasma volume fraction (Vp)], DSC-PWI parameter [relative cerebral blood flow (rCBF)] and 3D-ASL parameter (rCBF) on BG pathological grading was analyzed. The differences in rCBF of DSC-PWI parameter and rCBF of 3D-ASL parameter were compared.Results There were no significant differences in Kep and Vp among different BG pathological grades (P＞0.05). Ktrans and Ve of BG pathological grade Ⅱ were significantly lower than those of grades Ⅲ and Ⅳ (P＜0.05), but there were no statistically significant differences in Ktrans and Ve between grade Ⅲ and grade Ⅳ (P＞0.05). In DSC-PWI and 3D-ASL, there were significant differences in rCBF values between patients with different BG pathological grades and the contralateral hemisphere, gray matter, and white matter (P＜0.05), and the rCBF values of grade Ⅱ were lower than those of grade Ⅲ and Ⅳ (P＜0.05), and the values of grade Ⅲ were lower than those of grade Ⅳ (P＜0.05). ROC curve analysis showed that rCBF values measured by Ktrans, Ve, DSC-PWI and 3D-ASL had high diagnostic value on BG pathology grade Ⅳ (P＜0.05). There was no significant difference in rCBF measured by DSC-PWI and 3D-ASL (P＞0.05).Conclusions The effect of DCE-MRI in judging BG grading is not as good as DSC-PWI and 3D-ASL. DSC-PWI measures more parameters than 3D-ASL, but its safety and non-invasiveness are not as good as 3D-ASL. The three perfusion techniques have their own advantages and disadvantages, thus it is necessary to select the appropriate perfusion technique according to the actual situation in clincial practice.
[Keywords] brain glioma；grading；dynamic contrast-enhanced magnetic resonance imaging；dynamic susceptibility contrast-enhanced perfusion weighted imaging；three-dimensional arterial spin labeling

MEI Zou1   BI Junying2*  

1 Department of Radiology, the Third People's Hospital of Hubei Province, Jianghan University, Wuhan 430000, China

2 Department of Medical Imaging Interventional and Magnetic Resonance Imaging, the Third People's Hospital of Hubei Province, Jianghan University, Wuhan 430000, China

Bi JY, E-mail: bijunying123@163.com

Conflicts of interest   None.

Received  2021-05-21
Accepted  2021-12-28
DOI: 10.12015/issn.1674-8034.2022.02.017
Cite this article as: Mei Z, Bi JY. Comparison of value of three MRI perfusion techniques in the preoperative assessment of brain glioma grading[J]. Chin J Magn Reson Imaging, 2022, 13(2): 83-86, 95. DOI:10.12015/issn.1674-8034.2022.02.017.

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