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Advances in magnetic resonance imaging studies in patients with cognitive impairment in type 2 diabetes mellitus
LI Renshi  HAN Xiaolin  HUA Mengyu  ZHUANG Xianghua  CHEN Shihong 

Cite this article as: Li RS, Han XL, Hua MY, et al. Advances in magnetic resonance imaging studies in patients with cognitive impairment in type 2 diabetes mellitus[J]. Chin J Magn Reson Imaging, 2022, 13(2): 108-111, 115. DOI:10.12015/issn.1674-8034.2022.02.026.


[Abstract] Type 2 diabetes mellitus causes structural and functional abnormalities in the brain and increases the risk of cognitive impairment. However, we are still unclear about the pathogenesis of cognitive impairment in type 2 diabetes mellitus. However advances in magnetic resonance imaging studies have further identified the neurological factors associated with type 2 diabetes mellitus leading to cognitive impairment. We systematically reviewed the literature on neuroimaging alterations in patients with type 2 diabetes mellitus that include changes in structure, brain function, and metabolites. Studies have shown that changes in the type 2 diabetes mellitus brain include atrophy of brain structures, high white matter signal, altered functional connectivity, cerebral microangiopathy, cerebral blood flow, and altered metabolites. Magnetic resonance imaging promises to further elucidate the basis of cognitive decline in type 2 diabetes mellitus and enable better diagnosis and treatment of the disease, offering potential translational opportunities for clinical intervention.
[Keywords] type 2 diabetes mellitus；cognitive impairment；structural magnetic resonance imaging；functional magnetic resonance imaging

LI Renshi   HAN Xiaolin   HUA Mengyu   ZHUANG Xianghua   CHEN Shihong*  

Department of Endocrinology, the Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China

Chen SH, E-mail: chenshihong26@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81670753, 82070847, 81800722); Undergraduate teaching reform and research project of Qilu Medical College of Shandong University (No. qlyxjy-201882).
Received  2021-09-08
Accepted  2022-01-30
DOI: 10.12015/issn.1674-8034.2022.02.026
Cite this article as: Li RS, Han XL, Hua MY, et al. Advances in magnetic resonance imaging studies in patients with cognitive impairment in type 2 diabetes mellitus[J]. Chin J Magn Reson Imaging, 2022, 13(2): 108-111, 115. DOI:10.12015/issn.1674-8034.2022.02.026.

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