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Advances in research on brain networks in psychogenic erectile dysfunction
YANG Yuqing  MOU Linxuan  QU Liu  YAO Junpeng  YAN Xiangyun  SU Chengguo  ZHANG Peihai  LI Ying 

Cite this article as: Yang YQ, Mou LX, Qu L, et al. Advances in research on brain networks in psychogenic erectile dysfunction[J]. Chin J Magn Reson Imaging, 2022, 13(2): 116-119. DOI:10.12015/issn.1674-8034.2022.02.028.


[Abstract] Erectile dysfunction (ED) is a common male sexual dysfunction disease, manifested by the persistent inability to achieve and maintain erection satisfactorily for sexual performance. Psychogenic erectile dysfunction (pED) is the most common type of ED, previously believed to be mainly caused by psychological factors. With the development of imaging technology, it has been widely confirmed that there were structural and functional network abnormalities in specific brain regions in patients with pED. The results of our review suggested that there were widely abnormal topological connection patterns of default mode network, cognitive control network, emotion/frontal-limbic system and salience network in the structural networks and functional networks of patients with pED, which might be a potential biomarker of pED. This finding will provide a new idea for the central neurophysiological mechanisms research of pED.
[Keywords] psychogenic erectile dysfunction；brain network；structural network；functional network

YANG Yuqing1   MOU Linxuan1   QU Liu1   YAO Junpeng1   YAN Xiangyun1   SU Chengguo1   ZHANG Peihai2   LI Ying3*  

1 Chengdu University of TCM, Chengdu 610075, China

2 Andrology Department, The Hospital of Chengdu University of traditional Chinese Medicine, Chengdu 610032, China

3 Graduate School, Chengdu University of Traditional Chinese Medicine, Chengdu 610072, China

Li Y, E-mail: liying@cdutcm.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS Key National Key Research and Development Project (No. 2019YFC1709100).
Received  2021-09-07
Accepted  2021-12-29
DOI: 10.12015/issn.1674-8034.2022.02.028
Cite this article as: Yang YQ, Mou LX, Qu L, et al. Advances in research on brain networks in psychogenic erectile dysfunction[J]. Chin J Magn Reson Imaging, 2022, 13(2): 116-119. DOI:10.12015/issn.1674-8034.2022.02.028.

[1]
Graf H, Walter M, Metzger CD, et al. Antidepressant-related sexual dysfunction-perspectives from neuroimaging[J]. Pharmacol Biochem Behav, 2014, 121: 138-145. DOI: 10.1016/j.pbb.2013.12.003.
[2]
McMahon CG. Current diagnosis and management of erectile dysfunction[J]. Med J Aust, 2019, 210(10): 469-476. DOI: 10.5694/mja2.50167.
[3]
Chen L, Shi GR, Huang DD, et al. Male sexual dysfunction: A review of literature on its pathological mechanisms, potential risk factors, and herbal drug intervention[J]. Biomed Pharmacother, 2019, 112: 108585. DOI: 10.1016/j.biopha.2019.01.046.
[4]
Yin T, Li Z, Xiong J, et al. Neuroimaging biomarkers of psychogenic erectile dysfunction: protocol for a systematic review[J]. BMJ Open, 2019, 9(8): e030061. DOI: 10.1136/bmjopen-2019-030061.
[5]
Chen JH, Chen Y. Brain magnetic resonance imaging in exploring the central neurophysiological mechanisms of penile erection: Progress in studies[J]. Zhong hua Nan Ke Xue, 2019, 25(5): 456-459. DOI: 10.13263/j.cnki.nja.2019.05.014.
[6]
Silva PHRD, Secchinato KF, Rondinoni C, et al. Brain Structural-Functional Connectivity Relationship Underlying the Information Processing Speed[J]. Brain Connect, 2020, 10(3): 143-154. DOI: 10.1089/brain.2019.0726.
[7]
Zuo NM, Jiang TZ. Multi-modal human brain mapping and Brainnetome study (in Chinese)[J]. Sci Sin Vitae, 2020, 50: 1296-1308. DOI: 10.1360/SSV-2019-0228.
[8]
Krupnik R, Yovel Y, Assaf Y. Inner-and inter-hemispheric connectivity balance in the human brain[J]. J Neurosci, 2021, JN-RM-1074-21. DOI: 10.1523/JNEUROSCI.1074-21.2021.
[9]
Huang JS, Jie B, Ding WP, et al. Brain Network Analysis:Method and Application[J]. Journal of Data Acquisition and Processing, 2021, 36(4): 648-663. DOI: 10.16337/j.1004-9037.2021.04.003.
[10]
Wang J, Kong LY, Lei BY, et al. Advances in research on complex brain networks in depression[J]. Chin J Med Phys, 2020, 6: 780-785. DOI: 10.3969/j.issn.1005-202X.2020.06.023.
[11]
Bullmore E, Sporns O. Complex brain networks: graph theoretical analysis of structural and functional systems[J]. Nat Rev Neurosci, 2009, 10(3): 186-198. DOI: 10.1038/nrn2575.
[12]
Porns O. Network attributes for segregation and integration in the human brain[J]. Curr Opin Neurobiol, 2013, 23(2): 162-171. DOI: 10.1016/j.conb.2012.11.015.
[13]
Rubinov M, Sporns O. Complex network measures of brain connectivity: uses and interpretations[J]. Neuroimage, 2010, 52(3): 1059-1069. DOI: 10.1016/j.neuroimage.2009.10.003.
[14]
Gong Q, He Y. Depression, neuroimaging and connectomics: a selective overview[J]. Biol Psychiatry, 2015, 77(3): 223-235. DOI: 10.1016/j.biopsych.2014.08.009.
[15]
Li XL, Yao CL, Wang F, et al. Advances in imaging studies of senile depression[J]. Chin J Magn Reson Imaging, 2020, 11(3): 228-231. DOI: 10.12015/issn.1674-8034.2020.03.015.
[16]
Yeh CH, Jones DK, Liang X, et al. Mapping Structural Connectivity Using Diffusion MRI: Challenges and Opportunities[J]. J Magn Reson Imaging, 2021, 53(6): 1666-1682. DOI: 10.1002/jmri.27188.
[17]
Tamura Y, Shimoji K, Ishikawa J, et al. Subclinical Atherosclerosis, Vascular Risk Factors, and White Matter Alterations in Diffusion Tensor Imaging Findings of Older Adults With Cardiometabolic Diseases[J]. Front Aging Neurosci, 2021, 13: 712385. DOI: 10.3389/fnagi.2021.712385.
[18]
Chen JH, Yao ZJ. Research progress of complex brain network theory based on graph theory in depression[J]. J Clin Psychiatry, 2016, 26(4): 272-274.
[19]
Zhao L, Guan M, Zhang X, et al. Structural insights into aberrant cortical morphometry and network organization in psychogenic erectile dysfunction[J]. Hum Brain Mapp, 2015, 36(11): 4469-4482. DOI: 10.1002/hbm.22925.
[20]
Drevets WC, Savitz J, Trimble M. The subgenual anterior cingulate cortex in mood disorders[J]. CNS Spectr, 2008, 13(8): 663-681. DOI: 10.1017/s1092852900013754.
[21]
Zhao L, Guan M, Zhu X, et al. Aberrant Topological Patterns of Structural Cortical Networks in Psychogenic Erectile Dysfunction[J]. Front Hum Neurosci, 2015, 9: 675. DOI: 10.3389/fnhum.2015.00675.
[22]
Chen JH, Chen GT, Chen Y, et al. Correlation of abnormal topological properties of the white matter fibers connecting the left amygdale with psychogenic erectile dysfunction[J]. Zhong hua Nan Ke Xue, 2017, 23(4): 323-328. DOI: 10.13263/j.cnki.nja.2017.04.007.
[23]
Chen J, Chen Y, Gao Q, et al. Impaired Prefrontal-Amygdala Pathway, Self-Reported Emotion, and Erection in Psychogenic Erectile Dysfunction Patients With Normal Nocturnal Erection[J]. Front Hum Neurosci, 2018, 12: 157. DOI: 10.3389/fnhum.2018.00157.
[24]
Chen J, Chen Y, Gao Q, et al. Brain structural network topological alterations of the left prefrontal and limbic cortex in psychogenic erectile dysfunction[J]. Int J Neurosci, 2018, 128(5): 393-403. DOI: 10.1080/00207454.2017.1387116.
[25]
Hu DY, Liu FF, Chen X. Dissociation of Specific Effects of Amygdala on Fear Recognition and Fear Experience[J]. Chin J Clin Psycho, 2018, 4: 688-693. DOI: 10.16128/j.cnki.1005-3611.2018.04.013.
[26]
Zhang HJ, Li F, Li CJZ, et al. Advance in pplication of Neuroimaging in Plasticity Mechanism after Stroke (review)[J]. Chin J Rehabil Theory Pract, 2021, 27(1): 48-53. DOI: 10.3969/j.issn.1006-9771.2021.01.007.
[27]
Yu H, Deng Y, Zhang YQ, et al.Research progress of task-state and resting-state functional magnetic resonance imaging in neuropsychiatric systemic lupus erythematosus[J]. Chin J Magn Reson Imaging, 2018, 9(8): 565-569. DOI: 10.12015/issn.1674-8034.2018.08.005.
[28]
Cera N, Di Pierro ED, Ferretti A,et al. Brain networks during free viewing of complex erotic movie: new insights on psychogenic erectile dysfunction[J]. PLoS One, 2014, 9(8): e105336. DOI: 10.1371/journal.pone.0105336.
[29]
Chen J, Chen Y, Chen G,et al. Altered brain networks in psychogenic erectile dysfunction: a resting-state fMRI study[J]. Andrology, 2017, 5(6): 1073-1081. DOI: 10.1111/andr.12411.
[30]
Wang Y, Dong M, Guan M,et al. Aberrant Insula-Centered Functional Connectivity in Psychogenic Erectile Dysfunction Patients: A Resting-State fMRI Study[J]. Front Hum Neurosci, 2017, 11: 221. DOI: 10.3389/fnhum.2017.00221.
[31]
Zhang PH,Qu XJ, Pan JJ, et al. Correlation study on psychological erectile dysfunction and brain area function[J]. Chin J Androl, 2015, 1: 60-62. DOI: 10.3969/j.issn.1008-0848.2015.01.015.
[32]
Cera N, Castelhano J, Oliveira C, et al. The role of anterior and posterior insula in male genital response and in visual attention: an exploratory multimodal fMRI study[J]. Sci Rep, 2020, 10(1): 18463. DOI: 10.1038/s41598-020-74681-x.
[33]
Kam JWY, Solbakk AK, Endestad T, et al. Lateral prefrontal cortex lesion impairs regulation of internally and externally directed attention[J]. Neuroimage, 2018, 175: 91-99. DOI: 10.1016/j.neuroimage.2018.03.063.
[34]
Cheng JC, Secondary J, Burke WH,et al. Neuroimaging and sexual behavior: identification of regional and functional differences[J]. Curr Psychiatry Rep, 2015, 17(7): 55. DOI: 10.1007/s11920-015-0593-x.
[35]
Corbetta M, Patel G, Shulman GL. The reorienting system of the human brain: from environment to theory of mind[J]. Neuron, 2008, 58(3): 306-324. DOI: 10.1016/j.neuron.2008.04.017.
[36]
Chen J, Huang X, Liu S, et al. Disrupted topological properties of brain networks in erectile dysfunction patients owing predominantly to psychological factors: a structural and functional neuroimaging study[J]. Andrology, 2020, 8(2): 381-391. DOI: 10.1111/andr.12684.
[37]
Yin T, Liu Q, Ma Z, et al. Associations Between Altered Cerebral Activity Patterns and Psychosocial Disorders in Patients With Psychogenic Erectile Dysfunction: A Mediation Analysis of fMRI[J]. Front Psychiatry, 2020, 11: 583619. DOI: 10.3389/fpsyt.2020.583619.
[38]
Cao WY, Liao HY, Cai SN, et al. Whole-brain Functional Connectivity of Amygdala and Prefrontal Cortex in Patients with Borderline Personality Disorder[J]. Chin J Clin Psycho, 2020, 28(6): 1077-1082. DOI: 10.16128/j.cnki.1005-3611.2020.06.001.
[39]
Šimić G, Tkalčić M, Vukić V, et al. Understanding Emotions: Origins and Roles of the Amygdala[J]. Biomolecules. 2021,11(6): 823. DOI: 10.3390/biom11060823.
[40]
Ren FQ. The Study on the central Regulation Mechanism of Chaihu-Shugan Powder Influencing on the Therapeutic Effect of Treating for Liver-qi Stagnation-type Psychological Erectile Dysfunction[D]. Chengdu University of Traditional Chinese Medicine, 2020. DOI: 10.26988/d.cnki.gcdzu.2020.000029.

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