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• Clinical Articles •
MR elastography for evaluation of pathological grade of pancreatic ductal adenocarcinoma
SONG Qike  ZHONG Shiling  LIU Yuanyuan  YANG Rui  SHI Yu 

Cite this article as: Song QK, Zhong SL, Liu YY, et al. MR elastography for evaluation of pathological grade of pancreatic ductal adenocarcinoma[J]. Chin J Magn Reson Imaging, 2022, 13(3): 26-30. DOI:10.12015/issn.1674-8034.2022.03.006.


[Abstract] Objective To investigate the prognostic value of magnetic resonance elastography (MRE) in patients with pancreatic ductal adenocarcinoma (PDAC) and its correlation with histopathological grade.Materials and Methods MRE examination was performed in 62 patients diagnosed with PDAC and undergoing pancreaticoduodenectomy. The stiffness was measured, tumor location, margin status and histopathological grade were extracted from postoperative pathological reports. The Cox proportional risk model was used to determine the role of stiffness in predicting overall survival (OS) and the relationship between tumor hardness and pathology was analyzed.Results The mean stiffness of all PDACs was (3.06±0.82) kPa. The mean stiffness of patients with well, moderate, and poorly differentiated PDAC were (2.31±0.62) kPa, (2.98±0.78) kPa and (3.83±1.08) kPa, respectively. There were statistically significant differences in elasticity among different histopathological grades (P＜0.001). The elasticity of PDAC were positively correlated with the pathological grades of PDAC (rs=0.831, P＜0.001). The area under curve (AUC) of MRE stiffness diagnosed well and moderate-poorly differentiated, well-moderate and poorly differentiated PDAC were 0.826 and 0.884, respectively. Stiffness was an independent risk factor for the survival time of PDAC patients (P＜0.001).Conclusions The stiffness of PDAC was significant correlation to pathological grades of tumor; and the high stiffness was associated with lower overall survival rates after attempted curative resection of PDAC.
[Keywords] pancreatic neoplasms；prognosis；elasticity imaging techniques；magnetic resonance imaging；stiffness；diagnosis；overall survival

SONG Qike   ZHONG Shiling   LIU Yuanyuan   YANG Rui   SHI Yu*  

Department of Radiology, Shengjing Hospital of China Medical University, Shenyang 110004, China

Shi Y, E-mail: 18940259980@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82071885, 81771802, 81771893); National Ten Thousand Talents Program of the Central Organization Department.
Received  2021-07-23
Accepted  2022-02-10
DOI: 10.12015/issn.1674-8034.2022.03.006
Cite this article as: Song QK, Zhong SL, Liu YY, et al. MR elastography for evaluation of pathological grade of pancreatic ductal adenocarcinoma[J]. Chin J Magn Reson Imaging, 2022, 13(3): 26-30. DOI:10.12015/issn.1674-8034.2022.03.006.

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