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• Original Article •
Study on the change of resting state degree centrality and correlation in patients with obstructive sleep apnea
GAO Jing  TIAN Jing  HUANG Gang  ZHANG Wenwen  FANG Yanyan  ZHAO Lianping 

Cite this article as: Gao J, Tian J, Huang G, et al. Study on the change of resting state degree centrality and correlation in patients with obstructive sleep apnea[J]. Chin J Magn Reson Imaging, 2022, 13(4): 79-83, 88. DOI:10.12015/issn.1674-8034.2022.04.014.


[Abstract] Objective To utilize the resting state magnetic resonance imaging degree centrality (DC) techniques to explore the Abnormal alterations in the centrality of whole brain network nodes in patients with obstructive sleep apnea (OSA).Materials and Methods Thirty-nine newly diagnosed and treatment-naïve patients with OSA and 52 healthy controls were prospectively included for MRI cranial scan and cognitive psychological scale assessment. Compare the differences of whole brain DC values between the two groups, and then correlated with cognitive psychological scale scores and clinical data for analysis.Results Compared with controls, patients with OSA presented significantly lower DC values in the right precuneus and left medial superior frontal gyrus and significantly higher DC values in the right parahippocampal gyrus (GRF corrected, P＜0.001 for single voxels, P＜0.05 for cluster size). DC values of the left medial superior frontal gyrus was positively correlated with Insomnia Severity Index scores (r=0.326, P=0.043); DC values of the right parahippocampal gyrus was negatively correlated with the total Montreal Cognitive Assessment Scale (MoCA) score (r=-0.361, P=0.024) and MoCA memory score (r=-0.333, P=0.039).Conclusions Patients with OSA have abnormal DC values in the core brain regions of the default mode network and the parahippocampal gyrus, and such abnormalities are primarily associated with the cognitive memory function,which may be important neuroimaging biological markers of cognitive dysfunction in patients with OSA.
[Keywords] sleep apnea, obstructive；magnetic resonance imaging；degree centrality；cognitive dysfunction；emotional abnormalities

GAO Jing1   TIAN Jing1   HUANG Gang2   ZHANG Wenwen2   FANG Yanyan2   ZHAO Lianping2*  

1 The First Clinical Medical College, Gansu University of Chinese Medicine(Gansu Provincial Hospital), Lanzhou 730000, China

2 Department of Radiology, Gansu Provincial Hospital, Lanzhou 730000, China

Zhao LP, E-mail: lianping_zhao007@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81901724); Natural Science Foundation of Gansu Province (No. 21JR7RA593); 2022 Gansu Province Excellent Graduate Students Iinnovation Star" Project.
Received  2021-12-15
Accepted  2022-03-21
DOI: 10.12015/issn.1674-8034.2022.04.014
Cite this article as: Gao J, Tian J, Huang G, et al. Study on the change of resting state degree centrality and correlation in patients with obstructive sleep apnea[J]. Chin J Magn Reson Imaging, 2022, 13(4): 79-83, 88. DOI:10.12015/issn.1674-8034.2022.04.014.

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