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Research progress of rs-fMRI in brain ischemic white matter lesions
ZHANG Hui  DING Jurong  YAN Chengdong  FENG Chenyu  LI Yuan  LIU Yihong  ZHANG Yujiao  DING Xin 

Cite this article as: Zhang H, Ding JR, Yan CD, et al. Research progress of rs-fMRI in brain ischemic white matter lesions[J]. Chin J Magn Reson Imaging, 2022, 13(4): 154-157. DOI:10.12015/issn.1674-8034.2022.04.034.


[Abstract] Ischemic white matter lesions (WML) involves substantial damage to brain structure and function, which is common in elderly adults over 60 years old, mainly affecting cognitive function, motor function, and daily communication. However, the pathogenesis of WML is still unclear. Resting-state functional magnetic resonance imaging (rs-fMRI) is an emerging technology to detect spontaneous neural activity in the brain in resting state noninvasively, and is often used to study the pathological mechanism of cognitive and behavioral dysfunction in WML patients. This paper reviews the research progress of rs-fMRI analysis methods in WML, including regional homogeneity, functional connection, resting-state network, graph theory analysis, and amplitude of low-frequency fluctuation.
[Keywords] white matter lesions；resting-state functional magnetic resonance imaging；cognitive impairment；regional homogeneity；functional connectivity；amplitude of low-frequency fluctuation

ZHANG Hui1, 2   DING Jurong1, 2*   YAN Chengdong1   FENG Chenyu1   LI Yuan1   LIU Yihong1   ZHANG Yujiao3   DING Xin4  

1 College of Automation and Information Engineering, Sichuan University of Science & Engineering, Yibin 644000, China

2 Artificial Intelligence Key Laboratory of Sichuan Province, Sichuan University of Science & Engineering, Yibin 644000, China

3 School of Clinical Medicine, Chengdu Medical College, Chengdu 610000, China

4 Department of Neurology, the First Affiliated Hospital of Chengdu Medical College, Chengdu 610000, China

Ding JR, E-mail: jurongding@gmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81401482); Sichuan Medical Association•Sichuan Medical Research Project (No. S19082); Talent Introduction Project of Sichuan University of Science & Engineering (No. 2020RC31).
Received  2021-11-30
Accepted  2022-04-07
DOI: 10.12015/issn.1674-8034.2022.04.034
Cite this article as: Zhang H, Ding JR, Yan CD, et al. Research progress of rs-fMRI in brain ischemic white matter lesions[J]. Chin J Magn Reson Imaging, 2022, 13(4): 154-157. DOI:10.12015/issn.1674-8034.2022.04.034.

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