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• Clinical Article •
Correlation analysis of breast MRI-based background parenchymal enhancement with different molecular subtypes and clinical factors of breast cancer
WU Di  GAO Qian  GAO Chao  LUO Chunyan  JIANG Jie  LIU Xiaoying  LI Jun 

Cite this article as: Wu D, Gao Q, Gao C, et al. Correlation analysis of breast MRI-based background parenchymal enhancement with different molecular subtypes and clinical factors of breast cancer[J]. Chin J Magn Reson Imaging, 2022, 13(5): 40-44. DOI:10.12015/issn.1674-8034.2022.05.008.


[Abstract] Objective To explore the correlation between the dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) background parenchymal enhancement (BPE) characteristics and different molecular subtypes of breast cancer.Materials and Methods Retrospective analysis from 2019 to 2020 clinical and imaging data of patients undergoing breast magnetic resonance examination in our hospital. Select the first phase image evaluation of BPE after the contrast medium injection in DCE-MRI. Use Spearman's correlation test to compare BPE correlation with various clinical factors; χ2 test was used to compare the degree of BPE with different molecular subtypes of breast cancer, the difference between menopause or not.Results One hundred and ninety-nine cases were enrolled, of which 32 were Luminal A, 118 cases of Luminal B [Luminal B (HER-2 positive) 48 cases, Luminal B (HER-2 negative) 70 cases], 24 cases of HER-2 overexpression type, 25 cases of basal-like type. BPE has negative correlation with the patient's age, weight, and body mass index (BMI) (P＜0.05); BPE has no significant correlation with the patient's height; BPE has a positive correlation with the patient's menopause (P＜0.01), the BPE of menopausal patients is mainly minimal or mildly enhanced, and the BPE of non-menopausal patients is mainly mild or moderate enhancement, some were severe enhancement, and the difference was statistically significant (P＜0.01). BPE degree and the molecular subtypes of breast cancer were correlated (P＜0.05), but the results of the analysis showed no statistically significant difference among the groups (P=0.162); the combined degree of BPE was divided into minimal+mild, moderate+severe enhancement, the results showed that there was no difference in the degree of BPE among the molecular subtype groups (P=0.298).Conclusions There has a correlation between BPE with patient's age, weight, BMI, menopause or not. And the BPE is connected with the molecular subtypes of breast cancer, but there is no difference between the groups after grouping.
[Keywords] magnetic resonance imaging；dynamic contrast-enhanced；breast cancer；background parenchymal enhancement；molecular subtypes

WU Di   GAO Qian   GAO Chao   LUO Chunyan   JIANG Jie   LIU Xiaoying   LI Jun*  

Department of Medical Imaging, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China

Li J, E-mail: hhbt0356@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Basic Research Plan of Yunnan Science and Technology Plan Project (Special Project of Kunming Medical Association, No. 202101AY070001-101); Yunnan High-level Health Technical Personnel Training Program (No. H-2018007).
Received  2022-01-21
Accepted  2022-04-29
DOI: 10.12015/issn.1674-8034.2022.05.008
Cite this article as: Wu D, Gao Q, Gao C, et al. Correlation analysis of breast MRI-based background parenchymal enhancement with different molecular subtypes and clinical factors of breast cancer[J]. Chin J Magn Reson Imaging, 2022, 13(5): 40-44. DOI:10.12015/issn.1674-8034.2022.05.008.

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