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• Original Article •
Homogeneity of cognitive function altered in patients with minimal hepatic encephalopathy: A fMRI based study
YANG Xuhong  HUANG Xueying  LIU Wenxiao  WANG Minglei  GE Xin  ZHANG Wei  DANG Pei  DING Xiangchun  WANG Xiaodong 

Cite this article as: Yang XH, Huang XY, Liu WX, et al. Homogeneity of cognitive function altered in patients with minimal hepatic encephalopathy: A fMRI based study[J]. Chin J Magn Reson Imaging, 2022, 13(5): 77-81，88. DOI:10.12015/issn.1674-8034.2022.05.014.


[Abstract] Objective To explore the effects of regional homogeneity (ReHo) changes on cognitive function in patients with minimal hepatic encephalopathy (MHE).Materials and Methods Twenty-five patients with hepatitis B cirrhosis complicated with MHE (MHE group), 27 patients with hepatitis B cirrhosis without MHE (cirrhosis group) and 30 healthy control subjects (healthy control group) with matching gender, age and educational level were collected. All the subjects underwent blood oxygenation level dependent functional magnetic resonance imaging (BOLD-fMRI) scanning. The ReHo brain map was obtained after the original images were processed. Brain regions with ReHo differences among the healthy control group, the liver cirrhosis group and the MHE group were compared with Student's t-test. The correlation between the ReHo value of cerebral regions in the MHE group and the MoCA scale score was analyzed by Person correlation analysis.Results Compared with the healthy control group and the liver cirrhosis group, the NCT-A score of the MHE group was significantly increased, and the DST, MoCA scale scores were significantly decreased, with statistical difference (P＜0.01). Compared with the healthy control, the ReHo of the right middle frontal gyrus, middle temporal gyrus, inferior temporal gyrus and bilateral para-central lobule was significantly reduced in the MHE group, and the ReHo of the left anterior wedge lobe was increased, with statistical difference (P＜0.05). Correlation analysis showed that in the MHE group, the MoCA score were negatively correlated with average ReHo value of the left anterior central gyrus, the left superior temporal gyrus, and part of the occipital region (P＜0.05), and were positively correlated with the average ReHo value of the right superior marginal gyrus (P＜0.05).Conclusions The cognitive impairment in patients with MHE may be related to the changes of ReHo in the cerebral region.
[Keywords] minimal hepatic encephalopathy；cognitive function；regional homogeneity；blood oxygenation level-dependent；functional magnetic resonance imaging；the number connection Test-A；digital symbol test

YANG Xuhong1   HUANG Xueying2   LIU Wenxiao1   WANG Minglei2   GE Xin1   ZHANG Wei2   DANG Pei2   DING Xiangchun3   WANG Xiaodong2, 4*  

1 Ningxia Medical University School of Clinical Medicine, Yinchuan 750001, China

2 Department of Radiology, General Hospital of Ningxia Medical University, Yinchuan 750001, China

3 Department of Infectious Diseases, General Hospital of Ningxia Medical University, Yinchuan 750001, China

4 Key Laboratory of Craniocerebral Diseases of Ningxia Medical University, Yinchuan 750001, China

Wang XD, E-mail: xdw80@yeah.net

Conflicts of interest   None.

ACKNOWLEDGMENTS Natural Science Foundation of Ningxia (No. 2022AAC03487); Science and Technology Key Research Program of Ningxia (No. 2019BEG03037); Preponderant Discipline Groups of Neuroscience in Key Laboratory of Craniocerebral Diseases of Ningxia Medical University (No. LNKF202109).
Received  2021-12-10
Accepted  2022-03-21
DOI: 10.12015/issn.1674-8034.2022.05.014
Cite this article as: Yang XH, Huang XY, Liu WX, et al. Homogeneity of cognitive function altered in patients with minimal hepatic encephalopathy: A fMRI based study[J]. Chin J Magn Reson Imaging, 2022, 13(5): 77-81，88. DOI:10.12015/issn.1674-8034.2022.05.014.

[1]
Labenz C, Toenges G, Schattenberg JM, et al. Outcome Prediction of Covert Hepatic Encephalopathy in Liver Cirrhosis: Comparison of Four Testing Strategies[J]. Clin Transl Gastroenterol, 2020, 11(6): e00172. DOI: 10.14309/ctg.0000000000000172.
[2]
Rega D, Aiko M, Peñaranda N, et al. Patients with Minimal Hepatic Encephalopathy Show Altered Thermal Sensitivity and Autonomic Function[J]. J Clin Med, 2021, 10(2): E239. DOI: 10.3390/jcm10020239.
[3]
Formentin C, Zarantonello L, Mangini C, et al. Clinical, neuropsychological and neurophysiological indices and predictors of hepatic encephalopathy (HE)[J]. Liver Int, 2021, 41(5): 1070-1082. DOI: 10.1111/liv.14785.
[4]
Labenz C, Baron JS, Toenges G, et al. Prospective evaluation of the impact of covert hepatic encephalopathy on quality of life and sleep in cirrhotic patients[J]. Alimentary Pharmacology & Therapeutics, 2018, 48(3): 313-321. DOI: 10.1111/apt.14824.
[5]
Moran S, López-Sánchez M, Milke-García MDP, et al. Current approach to treatment of minimal hepatic encephalopathy in patients with liver cirrhosis[J]. World J Gastroenterol, 2021, 27(22): 3050-3063. DOI: 10.3748/wjg.v27.i22.3050.
[6]
Duan M, Wang XY, Zhao HL, et al. Effect of renal oxygen consumption on early diabetic nephropathy measured by blood oxygen level-dependent functional magnetic resonance imaging[J]. Chin J Diabetes Mellit, 2021, 13(10): 984-990. DOI: 10.3760/cma.j.cn115791-20210125-00044.
[7]
Xing YL, Fu SS, Li M, et al. Regional Neural Activity Changes in Parkinson's Disease-Associated Mild Cognitive Impairment and Cognitively Normal Patients[J]. Neuropsychiatr Dis Treat, 2021, 17: 2697-2706. DOI: 10.2147/NDT.S323127.
[8]
Chen C, Yan MY, Yu Y, et al. Alterations in Regional Homogeneity Assessed by fMRI in Patients with Migraine Without Aura[J]. J Med Syst, 2019, 43(9): 298. DOI: 10.1007/s10916-019-1425-z.
[9]
Sun Q, Fan WL, Ye J, et al. Abnormal Regional Homogeneity and Functional Connectivity of Baseline Brain Activity in Hepatitis B Virus-Related Cirrhosis With and Without Minimal Hepatic Encephalopathy[J]. Front Hum Neurosci, 2018, 12: 245. DOI: 10.3389/fnhum.2018.00245.
[10]
Burra P, Senzolo M, Pizzolato G, et al. Does liver-disease aetiology have a role in cerebral blood-flow alterations in liver cirrhosis?[J]. Eur J Gastroenterol Hepatol, 2004, 16(9): 885-890. DOI: 10.1097/00042737-200409000-00012.
[11]
Chinese Society of Hepatology. Chinese guidelines on the management of liver cirrhosis[J]. Chinese Journal of Hepatology, 2019, 27(11). DOI: 10.3760/cma.j.issn.1007-3418.2019.11.008.
[12]
Ferenci P, Lockwood A, Mullen K, et al. Hepatic encephalopathy-Definition, nomenclature, diagnosis, and quantification: Final report of the Working Party at the 11th World Congresses of Gastroenterology, Vienna, 1998[J]. Hepatology, 2002, 35(3): 716-721. DOI: 10.1053/jhep.2002.31250.
[13]
Li SW, Wang K, Yu YQ, et al. Psychometric hepatic encephalopathy score for diagnosis of minimal hepatic encephalopathy in China[J]. World J Gastroenterol, 2013, 19(46): 8745-8751. DOI: 10.3748/wjg.v19.i46.8745.
[14]
Yan CG, Wang XD, Zuo XN, et al. DPABI: Data Processing & Analysis for (Resting-State) Brain Imaging[J]. Neuroinformatics, 2016, 14(3): 339-351. DOI: 10.1007/s12021-016-9299-4.
[15]
Li Y, Liang P, Jia X, et al. Abnormal regional homogeneity in Parkinson's disease: a resting state fMRI study[J]. Clin Radiol, 2016, 71(1): e28-e34. DOI: 10.1016/j.crad.2015.10.006.
[16]
Shen YY, Wang WW, Wang Y, et al. Not Only in Sensorimotor Network: Local and Distant Cerebral Inherent Activity of Chronic Ankle Instability-A Resting-State fMRI Study[J]. Front Neurosci, 2022, 16: 835538. DOI: 10.3389/fnins.2022.835538.
[17]
Wandell BA, Dumoulin SO, Brewer AA. Visual field maps in human cortex[J]. Neuron, 2007, 56(2): 366-383. DOI: 10.1016/j.neuron.2007.10.012.
[18]
Wei GX, Dong HM, Yang Z, et al. Tai Chi Chuan optimizes the functional organization of the intrinsic human brain architecture in older adults[J]. Front Aging Neurosci, 2014, 6: 74. DOI: 10.3389/fnagi.2014.00074.
[19]
Lv XF, Qiu YW, Tian JZ, et al. Abnormal regional homogeneity of resting-state brain activity in patients with HBV-related cirrhosis without overt hepatic encephalopathy[J]. Liver int, 2013, 33(3): 375-383. DOI: 10.1111/liv.12096.
[20]
McCrea M, Cordoba J, Vessey G, et al. Neuropsychological characterization and detection of subclinical hepatic encephalopathy[J]. Arch Neurol, 1996, 53(8): 758-763. DOI: 10.1001/archneur.1996.00550080076015.
[21]
LI XL, Cai LN, Wang F, et al. FMRI Study on Brain Activation Area of Acupuncture at Chongyang and Gongsun Group[J]. J Clin Radiol, 2019, 38(6): 973-977. DOI: 10.13437/j.cnki.jcr.2019.06.007.
[22]
Chen HJ, Zhu XQ, Yang M, et al. Changes in the regional homogeneity of resting-state brain activity in minimal hepatic encephalopathy[J]. Neurosci Lett, 2012, 507(1): 5-9. DOI: 10.1016/j.neulet.2011.11.033.
[23]
Lockwood AH, Murphy BW, Donnelly KZ, et al. Positron-emission tomographic localization of abnormalities of brain metabolism in patients with minimal hepatic encephalopathy[J]. Hepatology, 1993, 18(5): 1061-1068.
[24]
Cao JH, Liu GZ, Li XK, et al. Dynamic functional connectivity changes in the triple networks and its association with cognitive impairment in hemodialysis patients[J]. Brain Behav, 2021, 11(8): e2314. DOI: 10.1002/brb3.2314.
[25]
Cavanna AE, Trimble MR. The precuneus: a review of its functional anatomy and behavioural correlates[J]. Brain, 2006, 129(Pt 3): 564-583. DOI: 10.1093/brain/awl004.
[26]
Sheng L, Yuan JJ, Lin QY, et al. Changes of brain functional magnetic resonance imaging before and after aripiprazole treatment in patients with first-episode Tourette syndrome[J]. Maternal and Child Health Care of China, 2021, 36(18): 4350-4354. DOI: 10.19829/j.zgfybj.issn.1001-4411.2021.18.065.
[27]
Lim SH, Dinner DS, Pillay PK, et al. Functional anatomy of the human supplementary sensorimotor area: results of extraoperative electrical stimulation[J]. Electroencephalogr Clin Neurophysiol, 1994, 91(3): 179-193. DOI: 10.1016/0013-4694(94)90068-x.
[28]
Gao YL, Wang SW, Tian SS, et al. The study of regional homogeneity and voxel-mirrored homotopic connectivity of minimal hepatic encephalopathy disease at resting-state fMRI[J]. Chin J Magn Reson Imaging, 2019, 10(12): 885-889. DOI: 10.12015/issn.1674-8034.2019.12.002.
[29]
Lin WC, Hsu TW, Chen CL, et al. Resting State-fMRI with ReHo Analysis as a Non-Invasive Modality for the Prognosis of Cirrhotic Patients with Overt Hepatic Encephalopathy[J]. PLoS One, 2015, 10(5): e126834. DOI: 10.1371/journal.pone.0126834.
[30]
Hahn B, Ross TJ, Stein EA. Neuroanatomical dissociation between bottom-up and top-down processes of visuospatial selective attention[J]. Neuroimage, 2006, 32(2): 842-853. DOI: 10.1016/j.neuroimage.2006.04.177.
[31]
Zhang GY, Li YX, Zhang XD, et al. Identifying Mild Hepatic Encephalopathy Based on Multi-Layer Modular Algorithm and Machine Learning[J]. Front Neurosci, 2020, 14: 627062. DOI: 10.3389/fnins.2020.627062.
[32]
Cao Y, Wu BL, Chen TL, et al. Altered intrinsic brain activity in patients with hepatic encephalopathy[J]. J Neurosci Res, 2021, 99(5): 1337-1353. DOI: 10.1002/jnr.24788.

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