Share：
Share this content in WeChat
X
[Chinese][PDF]67347
• Original Article •
Abnormal spontaneous brain activities in breast cancer patients after EC-T chemotherapy: A resting-state functional magnetic resonance imaging study
FENG Wei  LIU Tonghui  LI Peng  WANG Xueyuan  CHEN Rui  ZHANG Huawen  NING Long 

Cite this article as: Feng W, Liu TH, Li P, et al. Abnormal spontaneous brain activities in breast cancer patients after EC-T chemotherapy: A resting-state functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2022, 13(6): 56-60. DOI:10.12015/issn.1674-8034.2022.06.011.


[Abstract] Objective Using resting-state functional magnetic imaging (rs-fMRI) and amplitude of low frequency fluctuation (ALFF) algorithm to investigate the abnormal spontaneous brain activities and related cognitive dysfunction in breast cancer patients after chemotherapy.Materials and Methods We selected twenty-nine patients with invasive ductal carcinoma of the breast (patients group) confirmed by pathology. All patients were female and all received standard EC-T (E: Epirubicin; C: Cyclophosphamide; T: Paclitaxel) sequential chemotherapy. Thirty age- and education level matched female healthy volunteers (controls group) were selected during the same period. All subjects first underwent Montreal Cognitive Assessment (MoCA) and Auditory Verbal Learning Test-Huashan version (AVLT-H), 3D brain volume imaging and rs-fMRI scans. Finally, the DPARSF software package was used for processing and statistical analysis. The SPSS 19.0 software package was used for statistical analysis of clinical data and scales.Results The MoCA scores of the patients group were lower than controls group (P=0.002). There was no significant difference in the scores of each sub-item of AVLT-H between-group (P＞0.05). The ALFF values of left dorsolateral superior frontal gyrus (Frontal_Sup_L) in the Patients group were higher than controls group (P＜0.001), whereas the ALFF values of cerebellar vermis_6 (Vermis_6) and left lateral cingulate gyrus (Cingulum_Ant_L) were lower than the controls group (P＜0.001). Pearson correlation analysis showed that the ALFF values of the left lateral cingulate gyrus were significantly positive correlated with the MoCA score (r=0.789, P＜0.001).Conclusions Patients with breast invasive ductal carcinoma after EC-T chemotherapy have global cognitive dysfunction. Spontaneous neural activity abnormalities in key brain regions are closely related to the overall cognitive impairment. Spontaneous brain activity abnormalities in these regions are expected to become imaging markers for monitoring and treatment of breast cancer patients' cognitive dysfunction after EC-T chemotherapy.
[Keywords] breast cancer；cognitive dysfunction；chemotherapy；amplitude of low frequency fluctuation；resting-state functional magnetic resonance imaging

FENG Wei   LIU Tonghui   LI Peng   WANG Xueyuan   CHEN Rui   ZHANG Huawen   NING Long*  

Department of Medical Imaging, 215 Hospital of Shaanxi Nuclear Industry, Xianyang 712001, China

Ning L, E-mail: 254431957@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Shaanxi Science and Technology Research Plan (No. 2019SF-209).
Received  2021-10-20
Accepted  2022-04-13
DOI: 10.12015/issn.1674-8034.2022.06.011
Cite this article as: Feng W, Liu TH, Li P, et al. Abnormal spontaneous brain activities in breast cancer patients after EC-T chemotherapy: A resting-state functional magnetic resonance imaging study[J]. Chin J Magn Reson Imaging, 2022, 13(6): 56-60. DOI:10.12015/issn.1674-8034.2022.06.011.

[1]
Fahad Ullah M. Breast cancer:current perspectives on the disease status[J]. Adv Exp Med Biol, 2019, 1152: 51-64. DOI: 10.1007/978-3-030-20301-6_4.
[2]
Ongnok B, Chattipakorn N, Chattipakorn SC. Doxorubicin and cisplatin induced cognitive impairment: The possible mechanisms and interventions[J]. Exp Neurol, 2020, 324: 113118. DOI: 10.1016/j.expneurol.2019.113118.
[3]
Wolters AF, van de Weijer SCF, Leentjens AFG, et al. Resting-state fMRI in Parkinson's disease patients with cognitive impairment: A meta-analysis[J]. Parkinsonism Relat Disord, 2019, 62: 16-27. DOI: 10.1016/j.parkreldis.2018.12.016.
[4]
Zheng FS, Cao PY, Zhou J, et al. Study on Neurologic and Cognitive Dysfunction in Breast Cancer Patients undergoing Chemotherapy with RS fMRI Imaging[J]. World Neurosurg, 2020, 149: 388-396. DOI: 10.1016/j.wneu.2020.10.088.
[5]
Zhang S, Luo Y, Dong Z, et al. Impact of periventricular hyperintensities and cystatin C on different cognitive domains in the population of non-demented elderly Chinese[J]. J Clin Neurosci, 2019, 68: 201-210. DOI: 10.1016/j.jocn.2019.05.053.
[6]
Zhao M, Chen G, Li T, et al. The Impact of Study Setting on Clinical Characteristics in Older Chinese Adults with Subjective Cognitive Decline: Baseline Investigation of Convenience and Population-Based Samples[J]. Biomed Res Int, 2021: 5538323. DOI: 10.1155/2021/5538323.
[7]
Lim MYL, Loo JHY. Screening an elderly hearing impaired population for mild cognitive impairment using Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA)[J]. Int J Geriatr Psychiatry, 2018, 33(7): 972-979. DOI: 10.1002/gps.4880.
[8]
Carlew AR, Smith EE, Goette W, et al. Montreal Cognitive Assessment (MoCA) scores in medically compromised patients: A scoping review[J]. Health Psychol, 2021, 40(10): 717-726. DOI: 10.1037/hea0001138.
[9]
Zang YF, He Y, Zhu CZ, et a1. Altered baseline brain activity in children with ADHD revealed by resting-state functional MRI[J]. Brain Dev, 2007, 29(2): 83-91. DOI: 10.1016/j.braindev.2006.07.002.
[10]
Veselinović T, Rajkumar R, Amort L, et al. Connectivity Patterns in the Core Resting-State Networks and Their Influence on Cognition[J/OL]. Brain Connect, 2021 [2021-10-20]. https://www.liebertpub.com/doi/10.1089/brain.2020.0943. DOI: 10.1089/brain.2020.0943.
[11]
Yuan Q, Qi W, Xue C, et al. Convergent Functional Changes of Default Mode Network in Mild Cognitive Impairment Using Activation Likelihood Estimation[J]. Front Aging Neurosci, 2021, 5(13): 708687. DOI: 10.3389/fnagi.2021.708687.
[12]
Mak LE, Minuzzi L, MacQueen G, et al. The Default Mode Network in Healthy Individuals: A Systematic Review and Meta-Analysis[J]. Brain Connect, 2017, 7(1): 25-33. DOI: 10.1089/brain.2016.0438.
[13]
Yeshurun Y, Nguyen M, Hasson U. The default mode network: where the idiosyncratic self meets the shared social world[J]. Nat Rev Neurosci, 2021, 22(3): 181-192. DOI: 10.1038/s41583-020-00420-w.
[14]
Zovetti N, Rossetti MG, Perlini C, et al. Default mode network activity in bipolar disorder[J]. Epidemiol Psychiatr Sci, 2020, 29: e166. DOI: 10.1017/S2045796020000803.
[15]
Smigielski L, Scheidegger M, Kometer M, et al. Psilocybin-assisted mindfulness training modulates self-consciousness and brain default mode network connectivity with lasting effects[J]. Neuroimage, 2019, 196: 207-215. DOI: 10.1016/j.neuroimage.2019.04.009.
[16]
Janelsins MC, Kesler SR, Ahles TA, et al. Prevalence, mechanisms, and management of cancer-related cognitive impairment[J]. Int Rev Psychiatry, 2014, 26(1): 102-113. DOI: 10.3109/09540261.2013.864260.
[17]
Briggs RG, Khan AB, Chakraborty AR, et al. Anatomy and White Matter Connections of the Superior Frontal Gyrus[J]. Clin Anat, 2020, 33(6): 823-832. DOI: 10.1002/ca.23523.
[18]
Guell X, Gabrieli JDE, Schmahmann JD. Triple representation of language, working memory, social and emotion processing in the cerebellum: convergent evidence from task and seed-based resting-state fMRI analyses in a single large cohort[J]. Neuroimage, 2018, 172: 437-449. DOI: 10.1016/j.neuroimage.2018.01.082.
[19]
Brissenden JA, Somers DC. Cortico-cerebellar networks for visual attention and working memory[J]. Curr Opin Psychol, 2019, 29: 239-247. DOI: 10.1016/j.copsyc.2019.05.003.
[20]
Rolls ET. The cingulate cortex and limbic systems for emotion, action, and memory[J]. Brain Struct Funct, 2019, 224(9): 3001-3018. DOI: 10.1016/B978-0-444-64196-0.00002-9.
[21]
Liu W, Song C, Zhang XY, et al. Effects of chemotherapy on resting brain activity and cognitive function in patients with breast cancer[J]. Chin J Magn Reson Imaging, 2019, 10 (3): 24-28. DOI: 10.12015/issn.1674-8034.2019.03.003.
[22]
Chen BT, Jin T, Patel SK, et al. Intrinsic brain activity changes associated with adjuvant chemotherapy in older women with breast cancer: a pilot longitudinal study[J]. Breast Cancer Res Treat, 2019, 176(1): 181-189. DOI: 10.1007/s10549-019-05230-y.
[23]
Loibl S, Untch M, Burchardi N, et al. A randomised phase II study investigating durvalumab in addition to an anthracycline taxane-based neoadjuvant therapy in early triple-negative breast cancer: clinical results and biomarker analysis of GeparNuevo study[J]. Ann Oncol, 2019, 30(8): 1279-1288. DOI: 10.1093/annonc/mdz158.
[24]
Gupta GK, Collier AL, Lee D, et al. Perspectives on Triple-Negative Breast Cancer: Current Treatment Strategies, Unmet Needs, and Potential Targets for Future Therapies[J]. Cancers (Basel), 2020, 12(9): 2392. DOI: 10.3390/cancers12092392.
[25]
Bissoli I, Muscari C. Doxorubicin and α-Mangostin oppositely affect luminal breast cancer cell stemness evaluated by a new retinaldehyde-dependent ALDH assay in MCF-7 tumor spheroids. Biomed Pharmacother, 2020, 124: 109927. DOI: 10.1016/j.biopha.2020.109927.
[26]
Chen BT, Chen Z, Patel SK, et al. Effect of chemotherapy on default mode network connectivity in older women with breast cancer[J]. Brain Imaging Behav, 2022, 16(1): 43-53. DOI: 10.1007/s11682-021-00475-y.
[27]
Dijkshoorn ABC, van Stralen HE, Sloots M, et al. Prevalence of cognitive impairment and change in patients with breast cancer: A systematic review of longitudinal studies[J]. Psychooncology, 2021, 30(5): 635-648. DOI: 10.1002/pon.5623.
[28]
Rodríguez Martín B, Fernández Rodríguez EJ, Rihuete Galve MI, et al. Study of Chemotherapy-Induced Cognitive Impairment in Women with Breast Cancer[J]. Int J Environ Res Public Health, 2020, 17(23): 8896. DOI: 10.3390/ijerph17238896.
[29]
Mounier NM, Abdel-Maged AE, Wahdan SA, et al. Chemotherapy-induced cognitive impairment (CICI): An overview of etiology and pathogenesis[J]. Life Sci, 2020, 258: 118071. DOI: 10.1016/j.lfs.2020.118071.

PREV Changes in voxel-mirrored homotopic connectivity of bilateral cuneus after acupuncture in migraine without aura patients
NEXT Study on time variability of brain activity in patients with irritable bowel syndrome with diarrhea based on dynamic amplitude of low-frequency fluctuation
  


LINK


Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn