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• Investigation Reseach •
Resting-state fMRI study of vulnerable brain regions in patients with primary insomnia: A Meta-analysis based on activation likelihood estimation
ZHANG Qin  HOU Yongzhe  ZHANG Wei  WANG Lin 

Cite this article as: Zhang Q, Hou YZ, Zhang W, et al. Resting-state fMRI study of vulnerable brain regions in patients with primary insomnia: A Meta-analysis based on activation likelihood estimation[J]. Chin J Magn Reson Imaging, 2022, 13(6): 88-93. DOI:10.12015/issn.1674-8034.2022.06.017.


[Abstract] Objective To examine the use of resting state functional magnetic resonance imaging (rs-fMRI) technology in the study of the more consistent impaired brain regions in patients with primary insomnia (PI), in order to uncover the potential neural mechanism of PI brain injury.Materials and Methods Before April 7 2022, the literature on changes in brain function in patients with PI was searched using regional honogeneity (ReHo) and amplitude of low-frequency fluctuation/fraction amplitude of low-frequency fluctuation/dynamic amplitude of low-frequency fluctuation (ALFF/fALFF/dALFF) analytic methods. The activation likelihood estimation (ALE) method was utilized to integrate and assess brain regions with aberrant spontaneous neural activity in patients with PI compared to healthy controls (HCs), based on tight exclusion criteria.Results A total of 19 literatures and 20 studies (706 instances of PI and 681 cases of HCs) were included in the results. Combining ReHo and ALFF/fALFF/dALFF data element analysis, the results revealed that the activity of the left fusiform gyrus and parahippocampal gyrus in PI patients was higher than in HCs (voxels were 3640 and 928 mm3, respectively, P＜0.05), and no brain region had lower activity. The results of ALFF data element analysis alone revealed that the activity of the left fusiform gyrus in PI patients was higher than in HCs (voxel was 1360 mm3, P＜0.05), and no brain region had lower activity. The results of ReHo data element analysis alone revealed areas of the brain where PI patients do not exhibit any increased or decreased brain regions relative to HCs.Conclusions In this paper, an ALE meta-analysis discovered that the more consistent susceptible brain regions in PI patients were the left fusiform gyrus and parahippocampal gyrus, which is helpful in understanding PI brain injury from a neuropathological standpoint.
[Keywords] resting state functional magnetic resonance imaging；primary insomnia；Meta analysis；activation likelihood estimation；spontaneous neural activity；impaired brain regions

ZHANG Qin1, 2   HOU Yongzhe1   ZHANG Wei2   WANG Lin2*  

1 First Clinical Medical College, Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

2 Gansu Cancer Clinical Medical Research Center of Integrated Traditional Chinese and Western Medicine/Department of Radiology, Affiliated Hospital of Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China

Wang L, E-mail: 836362298@qq.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Gansu Science and Technology Support Program (No. 18JR2FA001); Major Project of Education Department in Gansu Province (No. LCCX2021001).
Received  2022-04-18
Accepted  2022-06-06
DOI: 10.12015/issn.1674-8034.2022.06.017
Cite this article as: Zhang Q, Hou YZ, Zhang W, et al. Resting-state fMRI study of vulnerable brain regions in patients with primary insomnia: A Meta-analysis based on activation likelihood estimation[J]. Chin J Magn Reson Imaging, 2022, 13(6): 88-93. DOI:10.12015/issn.1674-8034.2022.06.017.

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