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MRI features of intracranial atypical teratoid/rhabdoid tumor and its correlation with the labeling index of Ki-67
NIU Junxia  RAN Yuncai  ZHANG Yong  WANG Xiao  BAI Jie  ZHANG Yan 

Cite this article as: Niu JX, Ran YC, Zhang Y, et al. MRI features of intracranial atypical teratoid/rhabdoid tumor and its correlation with the labeling index of Ki-67[J]. Chin J Magn Reson Imaging, 2022, 13(6): 94-97. DOI:10.12015/issn.1674-8034.2022.06.018.


[Abstract] Objective To investigate the MRI features of intracranial atypical teratoid/rhabdoid tumors (AT/RT) and the correlation between MRI features and the labeling index of Ki-67.Materials and Methods MRI features of 11 patients with intracranial AT/RT confirmed by the postoperative histopathology from November 2013 to May 2021 were retrospectively analyzed, and the correlation between MRI and the labeling index of Ki-67 was further studied.Results Nine cases occurred in the posterior cranial fossa; the maximum diameter was (37.08±2.57) mm; cystic degeneration occurred in 8 cases, hemorrhage in 6 cases, and mild edema around the focus in 3 cases. In diffusion weighted imaging (DWI) (b=1000 s/mm2), 7 cases showed high signal and 4 cases showed slightly high signal. MR enhanced scan was not performed in 1 case, 7 cases showed obvious inhomogeneous enhancement and 3 cases showed mild inhomogeneous enhancement. The range of Ki-67 was 30%–80%; there were 6 cases with high expression (Ki-67＞40%) and 5 cases with low expression (Ki-67≤40%). There was no significant difference between the two groups in the location and size of lesions, intratumoral hemorrhage, intratumoral cystic degeneration, peritumoral edema and enhancement degree. However, there was significant difference in apparent diffusion coefficient (ADC) value between the two groups (P＜0.05). Spearman correlation analysis showed that ADC value was negatively correlated with the labeling index of Ki-67 (r=-0.866, P＜0.01).Conclusions Intracranial AT/RT always has cystic degeneration, hemorrhage, and most of them have inhomogeneous signal intensity on MRI and obvious inhomogeneous enhancement on enhanced scan; ADC value was negatively correlated with the labeling index of Ki-67.
[Keywords] atypical teratoid/rhabdoid tumors；embryonal tumor；magnetic resonance imaging；Ki-67；apparent diffusion coefficient

NIU Junxia   RAN Yuncai   ZHANG Yong   WANG Xiao   BAI Jie   ZHANG Yan*  

Department of Magnetic Resonance, the First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China

Zhang Y, E-mail: fcczhangy61@zzu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS Henan Medical Science and Technology Tackling Program (No. 2018010007).
Received  2022-01-20
Accepted  2022-05-23
DOI: 10.12015/issn.1674-8034.2022.06.018
Cite this article as: Niu JX, Ran YC, Zhang Y, et al. MRI features of intracranial atypical teratoid/rhabdoid tumor and its correlation with the labeling index of Ki-67[J]. Chin J Magn Reson Imaging, 2022, 13(6): 94-97. DOI:10.12015/issn.1674-8034.2022.06.018.

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