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Application progress of hepatobiliary specific contrast agent MRI in diffuse disease of the liver
REN Xue  LIU Ailian  ZHAO Ying 

Cite this article as: Ren X, Liu AL, Zhao Y. Application progress of hepatobiliary specific contrast agent MRI in diffuse disease of the liver[J]. Chin J Magn Reson Imaging, 2022, 13(6): 151-154，159. DOI:10.12015/issn.1674-8034.2022.06.032.


[Abstract] MRI plays an important role in the detection and diagnosis of liver disease. As a new type of cell-specific contrast agent, hepatobiliary-specific contrast agent can be specifically taken up by normal hepatocytes, while the uptake of impaired hepatocytes is reduced. This characteristic not only makes it possible to obtain information of the overall liver function, but also has unique advantages in the assessment of segmental liver function. This article first introduces the principle of hepatobiliary specific contrast agent MRI, and the application progress in liver diffuse disease such as fatty liver, liver fibrosis, hepatitis, cirrhosis, liver ischemia is reviewed. The combination of hepatobiliary specific contrast agent and artificial intelligence methods in liver function assessment have also been reviewed.
[Keywords] magnetic resonance imaging；liver；liver function；diffuse liver disease；hepatocyte-specific contrast media；gadobenate dimeglumine；gadolinium-ethoxybenzyl-diethylenetriamine；artificial intelligence

REN Xue1   LIU Ailian1, 2*   ZHAO Ying1  

1 Department of Radiology, the First Affiliated Hospital of Dalian Medical University, Dalian 116011, China

2 Engineering Research Center for Artificial Intelligence in Medical Imaging, Dalian 116011, China

Liu AL, E-mail: cjr.liuailian@vip.163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 61971091); Wu Jieping Medical Foundation Special Fund for Clinical Research (No. 320.6750.2021-06-25).
Received  2022-03-30
Accepted  2022-05-23
DOI: 10.12015/issn.1674-8034.2022.06.032
Cite this article as: Ren X, Liu AL, Zhao Y. Application progress of hepatobiliary specific contrast agent MRI in diffuse disease of the liver[J]. Chin J Magn Reson Imaging, 2022, 13(6): 151-154，159. DOI:10.12015/issn.1674-8034.2022.06.032.

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