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• Original Article •
Abnormal degree centrality values in the frontotemporal lobe, cerebellum and sensorimotor regions are associated with gait freezing in Parkinson's patients
TANG Wei  XU Qian  GAO Tingting  DONG Liao  YANG Guang  DU Xiaoxia  CHEN Wei 

Cite this article as: Tang W, Xu Q, Gao TT, et al. Abnormal degree centrality values in the frontotemporal lobe, cerebellum and sensorimotor regions are associated with gait freezing in Parkinson's patients[J]. Chin J Magn Reson Imaging, 2022, 13(7): 84-89. DOI:10.12015/issn.1674-8034.2022.07.015.


[Abstract] Objective The purpose of this study is to investigate the changes of degree centrality (DC) in Parkinson's disease (PD) patients with freezing of gait (FOG) by resting-state functional magnetic resonance imaging (rs-fMRI) and to explore the pathological mechanism of FOG.Materials and Methods A total of 17 patients with PD with FOG (FOG+), 36 patients with PD without FOG (FOG-), and 44 healthy controls (HC) were recruited. All subjects underwent rs-fMRI scanning. Calculate the DC values of FOG+, FOG- and HC from the resting-state data. The brain regions with statistically significant difference among the three groups were obtained by F test. Two sample t-test was used to compare the differences among FOG+, FOG- and HC. The results were assigned thresholds at P＜0.001 (voxel level) and Familywise error rate (FWE) corrected to P＜0.05 at the cluster level and cluster size＞20. The DC values of brain regions with statistically significant differences among groups were extracted and correlated with the scores of 17-item Hamilton Rating Scale for Depression (HAMD-17) and FOG questionnaire.Results The results showed that the main effects among the three groups were in the right anterior central gyrus, the right posterior central gyrus, the right insula, the right medial frontal gyrus, the right superior parietal lobule, and the right frontal lobe sub-gyral. Further two-sample analysis showed that compared with the HC group, DC value in the FOG+ group significantly decreased in the right medial frontal gyrus, left precentral gyrus, and right superior temporal gyrus; However, in the left superior frontal gyrus and the right superior frontal gyrus, there was a significant increase. Compared with the HC group, DC value in the FOG group increased significantly in the left superior frontal gyrus, right cerebellar Ⅸ lobule area, and decreased significantly in the right central posterior gyrus, left central posterior gyrus, right superior frontal gyrus, left central anterior gyrus and left external nucleus. In addition, the correlation analysis showed that the FOG questionnaire score of the FOG+ group was positively correlated with the DC values of the left precentral gyrus and the right superior temporal gyrus (r=0.574, P=0.020; r=0.506, P=0.046); HAMD-17 score was positively correlated with right medial frontal gyrus (r=0.547, P=0.028).Conclusions The abnormal DC values of the frontal lobe, anterior central gyrus, posterior central gyrus, temporal lobe, and cerebellum in PD patients may be closely related to the brain dysfunction of FOG+.
[Keywords] parkinson's disease；freezing of gait；degree centrality；magnetic resonance imaging

TANG Wei1   XU Qian2   GAO Tingting1   DONG Liao1   YANG Guang1   DU Xiaoxia3*   CHEN Wei2*  

1 Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China

2 Department of Neurology, Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China

3 School of Psychology, Shanghai University of Sport, Shanghai 200438, China

Du XX, E-mail: duxiaoxia@sus.edu.cn Chen W, E-mail: david_chen8106@hotmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Sciences Foundation of China (No.82071282); Biological Sample Bank Project of the Shanghai Ninth People's Hospital Shanghai Jiao Tong University School of Medicine (No. YBKB202120).
Received  2022-03-09
Accepted  2022-07-01
DOI: 10.12015/issn.1674-8034.2022.07.015
Cite this article as: Tang W, Xu Q, Gao TT, et al. Abnormal degree centrality values in the frontotemporal lobe, cerebellum and sensorimotor regions are associated with gait freezing in Parkinson's patients[J]. Chin J Magn Reson Imaging, 2022, 13(7): 84-89. DOI:10.12015/issn.1674-8034.2022.07.015.

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