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• Clinical Article •
A comparative study of amide proton transfer weighted imaging and intravoxel incoherent motion imaging in the diagnosis of pathological grade of lung adenocarcinoma and its correlation with SUVmax
FENG Pengyang  MENG Nan  FANG Ting  DONG Bai  YANG Yang  YUAN Jianmin  WEI Wei  WANG Meiyun  WU Yaping 

Cite this article as: Feng PY, Meng N, Fang T, et al. A comparative study of amide proton transfer weighted imaging and intravoxel incoherent motion imaging in the diagnosis of pathological grade of lung adenocarcinoma and its correlation with SUVmax[J]. Chin J Magn Reson Imaging, 2022, 13(8): 24-29. DOI:10.12015/issn.1674-8034.2022.08.005.


[Abstract] Objective To compare the value of amide amide proton transfer-weighted imaging (APTWI) and intravoxel incoherent motion (IVIM) imaging in identifying the pathological grade of lung adenocarcinoma, and to assess the correlation between each parameter and the metabolic parameter maximum standard uptake value (SUVmax) of 18F-FDG positron emission tomography (PET).Materials and Methods A total of 66 patients with postoperative pathologically confirmed lung adenocarcinoma were prospectively collected. APTWI, IVIM and 18F-FDG PET images were analyzed to measure the magnetization transfer ratio asymmetry [MTRasym (3.5 ppm)], diffusion coefficient (D), false diffusion coefficient (D*), perfusion fraction (f), distributed diffusion coefficient (DDC),diffusion heterogeneity index (α) and maximum standard uptake value (SUVmax). The differences and diagnostic efficacy of each parameter between different grading groups were compared and analyzed, and the correlation between each parameter value and SUVmax was evaluated.Results MTRasym (3.5 ppm) and f values in poorly differentiated group were higher than those in moderately/well differentiated group, while D and DDC values were lower than those in moderately/well differentiated group (all P＜0.05), there was no significant difference in D* and α values between the two groups. The AUC of MTRasym (3.5 ppm), D, DDC, f, α, and D* values for diagnosing the pathological grade of lung adenocarcinoma were 0.858, 0.743, 0.661, 0.645, 0.577, 0.531, respectively. The diagnostic efficiency of MTRasym (3.5 ppm) was significantly higher than that of other parameters except D value (P＜0.05). The combination of APTWI and IVIM had the highest diagnostic performance in identifying pathological grade (AUC=0.973). There was a weak positive correlation between MTRasym (3.5 ppm) and SUVmax value (r=0.396); D and DDC values were weakly negatively correlated with SUVmax value respectively (r=-0.359, -0.249, P＜0.05).Conclusions Both APTWI and IVIM are effective means to identify the pathological grade of lung adenocarcinoma. The diagnostic efficiency of APTWI parameters is better than IVIM, and some parameters are correlated with SUVmax.
[Keywords] positron emission tomography/magnetic resonance；amide proton transfer-weighted imaging；intravoxel incoherent motion；maximum standard uptake value；lung adenocarcinoma；pathological grade；differential diagnosis；correlation

FENG Pengyang1   MENG Nan2   FANG Ting2   DONG Bai3   YANG Yang4   YUAN Jianmin5   WEI Wei6   WANG Meiyun1, 2*   WU Yaping6  

1 Department of Radiology, Henan University People's Hospital (Henan Provincial People's Hospital), Zhengzhou 450003, China

2 Department of Radiology, Zhengzhou University People's Hospital, Zhengzhou 450003, China

3 Department of Orthopedics, Henan University People's Hospital, Zhengzhou 450003, China

4 Beijing United Imaging Research Institute of Intelligent Imaging, Beijing 100094, China

5 Shanghai United Imaging Medical Technology Co., Ltd., Shanghai 201815, China

6 Department of Radiology, Henan Provincial People's Hospital, Zhengzhou 450003, China

Wang MY, E-mail: mywang@zzu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS National Key R&D Program of China (No. 2017YFE0103600); Zhengzhou Collaborative Innovation Major Project (No. 20XTZX05015); Key Project of Henan Province Medical Science and Technology Project (No. LHGJ20210005).
Received  2022-03-19
Accepted  2022-07-27
DOI: 10.12015/issn.1674-8034.2022.08.005
Cite this article as: Feng PY, Meng N, Fang T, et al. A comparative study of amide proton transfer weighted imaging and intravoxel incoherent motion imaging in the diagnosis of pathological grade of lung adenocarcinoma and its correlation with SUVmax[J]. Chin J Magn Reson Imaging, 2022, 13(8): 24-29. DOI:10.12015/issn.1674-8034.2022.08.005.

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