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Value of magnetic resonance imaging in evaluating anatomical structure of hippocampus in patients with senile dementia
GUO Hao  HE Rongli 

Cite this article as: Guo H, He RL. Value of magnetic resonance imaging in evaluating anatomical structure of hippocampus in patients with senile dementia[J]. Chin J Magn Reson Imaging, 2022, 13(8): 75-79. DOI:10.12015/issn.1674-8034.2022.08.014.


[Abstract] Objective To investigate the value of magnetic resonance imaging (MRI) in evaluating anatomical structure of hippocampus in patients with senile dementia.Materials and Methods Ninety three patients with senile dementia admitted to Fenyang Hospital of Shanxi Province from July 2019 to July 2021 were selected as the case group. Meanwhile, 40 healthy individuals who underwent physical examination in the same hospital during the same period were selected as the control group. All subjects received MRI scanning of hippocampus. Related MRI data of hippocampus were compared between the two groups. The Montreal Cognitive Assessment (MoCA) score and the Activity of Daily Living (ADL) score were used for cognitive assessment. The correlation between related MRI data of hippocampus and cognitive function in patients with senile dementia was analyzed.Results The bilateral (left and right) hippocampal areas (HFA) (t=-5.533, -6.615; P＜0.05), standardized hippocampal area (SHFA) (t=-3.824, -5.198; P＜0.001), hippocampal transverse diameter (HTD) (t=-4.602, -6.212; P＜0.001), and standardized hippocampal transverse diameter (SHTD) (t=-4.358, -9.464; P＜0.001) of the case group were smaller than those of the control group, while the temporal horn width (THW) (t=2.564, 3.956; P＜0.05), standardized temporal horn width (STHW) (t=4.076, 3.714; P＜0.001) and medial temporal atrophy (MTA) (t=22.477, 19.236; P＜0.001) scores were significantly higher than those of the control group. The case group had lower MoCA scores and higher ADL scores than the control group (t=15.541, 9.307, P＜0.05). Pearson correlation analysis showed that patients with senile dementia left and right bilateral SHFA (r=0.303, 0.462; P＜0.05), SHTD (r=0.233, 0.557; P＜0.05) were positively correlated with MoCA scores; SHFA (r=0.211, 0.213; P＜0.05), SHTD (r=0.330, 0.288; P＜0.05) were positively correlated with ADL score, while STHW were negatively correlated with MoCA and ADL scores (r=-0.452, -0.287, P＜0.05).Conclusions Hippocampal atrophy is more obvious in patients with senile dementia than in healthy people. MRI examination of hippocampus is conducive to accurate understanding of the degree of hippocampal atrophy in patients with mild senile dementia, thereby providing reference for developing clinical treatment plan.
[Keywords] senile dementia；Alzheimer's disease；magnetic resonance imaging；anatomical structure of hippocampus；application value

GUO Hao   HE Rongli*  

Department of Anatomy, School of Basic Medical Sciences, Shanxi Medical University, Taiyuan 030001, China

He RL, E-mail: herl2690@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Applied Basic Research Project of Shanxi Province (No. 201801D121264).
Received  2022-04-06
Accepted  2022-08-05
DOI: 10.12015/issn.1674-8034.2022.08.014
Cite this article as: Guo H, He RL. Value of magnetic resonance imaging in evaluating anatomical structure of hippocampus in patients with senile dementia[J]. Chin J Magn Reson Imaging, 2022, 13(8): 75-79. DOI:10.12015/issn.1674-8034.2022.08.014.

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