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• Clinical Article •
Meta-analysis of local spontaneous brain activity changes in acute and subacute mild traumatic brain injury
YUAN Wenhuan  LUO Lin  WANG Yunlin  JIN Tao  YU Dahua 

Cite this article as: Yuan WH, Luo L, Wang YL, et al. Meta-analysis of local spontaneous brain activity changes in acute and subacute mild traumatic brain injury[J]. Chin J Magn Reson Imaging, 2022, 13(9): 13-17, 24. DOI:10.12015/issn.1674-8034.2022.09.003.


[Abstract] Objective To explore the most consistent vulnerable regions of mild traumatic brain injury (mTBI) studied by resting state functional magnetic resonance imaging (rs-fMRI), and to reveal the underlying neural mechanism of mTBI.Materials and Methods A search was performed for studies on mTBI resting state brain activation abnormalities by regional homogeneity (ReHo), amplitude of low-frequency fluctuation (ALFF) and fraction amplitude of low-frequency fluctuation (fALFF) before March 2022. The brain regions with abnormal local spontaneous brain activity in mTBI patients compared with healthy subjects in previous studies were summarized, and the signed differential mapping (SDM) software was used for data processing and analysis.Results A total of 11 studies (401 mTBI and 371 healthy controls) were included. Based on meta-analysis, it was confirmed that mTBI patients had significantly increased local spontaneous brain activity in right lingual gyrus, left middle occipital gyrus, right dorsolateral superior frontal gyrus and left central sulcus. Local spontaneous brain activity was decreased in the left anterior cingulate and paracingulate gyrus, right angular gyrus and left middle frontal gyrus (P＜0.005, peak height Z＞1, cluster extent≥20 voxels).Conclusions Meta-analysis was used to confirm the abnormal core brain regions in mTBI patients. These findings help delineate specific areas of interest and understand the neurobiological basis of mTBI.
[Keywords] mild traumatic brain injury；local spontaneous brain activity；meta-analysis；signed differential mapping；resting state functional magnetic resonance imaging

YUAN Wenhuan1   LUO Lin1*   WANG Yunlin1   JIN Tao1   YU Dahua2  

1 Department of Imaging, the First Affiliated Hospital of Baotou Medical College, Inner Mongolia University of Science and Technology, Baotou 014000, China

2 Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou 014000, China

*Luo L, E-mail: by11117@sina.com

Conflicts of interest   None.

ACKNOWLEDGMENTS Education Department Project of Inner Mongolia Autonomous Region (No. S20210171Z); Health Science and Technology Project of Baotou, Inner Mongolia (No. wsjkkj005).
Received  2022-06-13
Accepted  2022-09-07
DOI: 10.12015/issn.1674-8034.2022.09.003
Cite this article as: Yuan WH, Luo L, Wang YL, et al. Meta-analysis of local spontaneous brain activity changes in acute and subacute mild traumatic brain injury[J]. Chin J Magn Reson Imaging, 2022, 13(9): 13-17, 24. DOI:10.12015/issn.1674-8034.2022.09.003.

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