Correlation between Gd-EOB-DTPA enhanced MRI T1 mapping and Ki-67 expression in hepatocellular carcinoma

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• Clinical Article •

LIU Ziwei YANG Shaomin CHEN Haixiong GUO Baoliang ZHANG Rong ZHOU Cuiru LI Xiaohong HU Qiugen

Cite this article as: Liu ZW, Yang SM, Chen HX, et al. Correlation between Gd-EOB-DTPA enhanced MRI T1 mapping and Ki-67 expression in hepatocellular carcinoma[J]. Chin J Magn Reson Imaging, 2022, 13(9): 35-40, 52. DOI:10.12015/issn.1674-8034.2022.09.007.

Abstract

[Abstract] Objective To investigate the correlation between gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid (Gd-EOB-DTPA) enhanced MRI T1 mapping and Ki-67 expression in hepatocellular carcinoma (HCC).Materials and Methods The data of 74 patients diagnosed with HCC in Shunde Hospital, Southern Medical University (the First People's Hospital of Shunde) from July 2019 to December 2020 were retrospectively collected, and multiphase enhanced MRI scans with Gd-EOB-DTPA were performed before surgery, including pre-enhancement (Pre), arterial phase (AP), portal venous phase (PP), equilibrium phase (EP), hepatobiliary phase (HBP), T1 mapping, while Ki-67 staining was performed. Quantitative parameters including T1 relaxation time (T1rt), reduction rate of T1 relaxation time (rrT1rt), tumor to liver contrast ratio (TLR), contrast enhancement ratio (CER) were measured. The correlations between each quantitative parameter and the expression of pathological Ki-67 were analyzed using Spearman correlation coefficient. In addition, patients were divided into low Ki-67 expression group (≤25%, 40 cases) and high Ki-67 expression group (＞25%, 34 cases), and the differences of quantitative parameters between the two groups were compared by independent samples t test or Mann-Whitney U test. The diagnostic efficacy of each parameter was analyzed according to the receiver operating characteristic curve, and the difference of the area under the curve (AUC) of each parameter was compared by DeLong test (P＜0.05).Results T1rt-Pre, T1rt-20min are strongly positively correlated with Ki-67 [r=0.668 (95% CI: 0.515-0.780),r=0.659 (95% CI: 0.494-0.784),all P＜0.001]; TLR-Pre, TLR-HBP are moderately negatively correlated with Ki-67 [r=-0.495 (95% CI: -0.647--0.300), r=-0.497 (95% CI: -0.670--0.288), all P＜0.001]; TLR-PP, TLR-EP was weakly negatively correlated with Ki-67 [r=-0.272 (95% CI: -0.483--0.035), P=0.019; r=-0.362 (95% CI: -0.568--0.142), P=0.002]. There were significant differences in T1rt-Pre, T1rt-20min, TLR-Pre, TLR-AP, TLR-EP, TLR-HBP between the two groups (all P＜0.05). The AUC of T1rt-Pre, T1rt-20min, TLR-Pre, TLR-AP, TLR-EP, TLR-HBP were 0.868 (95% CI: 0.769-0.936); 0.890 (95% CI: 0.795-0.951); 0.717 (95% CI: 0.670-0.869); 0.646 (95% CI: 0.527-0.754); 0.680 (95% CI: 0.561-0.784); 0.782 (95% CI: 0.670-0.869), respectively. The AUC values of T1rt-Pre and T1rt-20min were significantly different from those of TLR-Pre, TLR-AP and TLR-EP respectively (all P＜0.05), but had no statistical difference with TLR-HBP.Conclusions T1rt-Pre, T1rt-20min on Gd-EOB-DTPA enhanced MRI combined with T1 mapping were strong positive correlation with the expression of Ki-67 in HCC, and T1rt-Pre and T1rt-20min has a high evaluation value for the expression of Ki-67 in HCC.

[Keywords] hepatocellular carcinoma；magnetic resonance imaging；Gd-EOB-DTPA；T1 mapping；Ki-67

Contributor Information

LIU Ziwei¹ YANG Shaomin² CHEN Haixiong¹ GUO Baoliang¹ ZHANG Rong¹ ZHOU Cuiru¹ LI Xiaohong¹ HU Qiugen^1*

¹ Department of Radiology, Shunde Hospital, Southern Medical University (the First People's Hospital of Shunde), Foshan 528308, China

² Department of Radiology, the Affiliated Shunde Hospital of Guangzhou Medical University, Foshan 528315, China

*Hu QG, E-mail: hu6009@163.com

Conflicts of interest None.

Publication Information

ACKNOWLEDGMENTS Guangdong Medical Science and Technology Research Fund (No. A2021483); Foshan Self-Funded Science and Technology Project (No. 2020001005216).

Received 2022-05-16

Accepted 2022-09-07

DOI: 10.12015/issn.1674-8034.2022.09.007

Text

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