Share:
Share this content in WeChat
X
Review
Research progress of brain fMRI by acupuncture at Houxi acupoint
XIA Meihui  ZHANG Qinhong  CAI Lina  YUE Jinhuan  LI Xiaoling  CUI Xuan  GAO Ruixue  TONG Xin  WANG Yang 

Co first author: ZHANG Qinhong DOI:10.12015/issn.1674-8034.2022.09.028.


[Abstract] Houxi acupoint is widely used in clinic because of its remarkable curative effect, but its acupuncture effect mechanism is not clear. Functional magnetic resonance imaging (fMRI) has become the first choice to visually explore the central effect mechanism of acupuncture acupoints. According to the relevant literature, the fMRI study on the brain after acupuncture at Houxi acupoint mainly focuses on the influencing factors and specificity. This paper analyzes the overall research trend in this field from the above two aspects, summarizes the relevant scientific research achievements and shortcomings, provides a better imaging basis for acupuncture clinical acupoint selection, and puts forward directional suggestions for follow-up acupuncture research.
[Keywords] acupuncture;Houxi acupoint;functional magnetic resonance imaging;influencing factors;specificity;magnetic resonance imaging

XIA Meihui1   ZHANG Qinhong2   CAI Lina3   YUE Jinhuan2   LI Xiaoling4*   CUI Xuan3   GAO Ruixue3   TONG Xin3   WANG Yang3, 4  

1 Department of Geriatrics, the Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150001, China

2 Department of Acupuncture and Massage, Shenzhen Jiuwei TCM Outpatient Department, Shenzhen 518000, China

3 Graduate School of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China

4 Department of CT & MR, the First Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin 150040, China

*Li XL, E-mail: lixiaoling1525@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82074537, 81373714); Natural Science Foundation Project of Heilongjiang Province (No. LH2020H103); Harbin Science and Technology Outstanding Discipline Leader Fund Project (No. 2016RAXYJ096).
Received  2022-06-08
Accepted  2022-09-10
DOI: 10.12015/issn.1674-8034.2022.09.028
Co first author: ZHANG Qinhong DOI:10.12015/issn.1674-8034.2022.09.028.

[1]
Tong QY, Liu R, Zhang K, et al. Can acupuncture therapy reduce preoperative anxiety? A systematic review and meta-analysis[J]. J Integr Med, 2021, 19(1): 20-28. DOI: 10.1016/j.joim.2020.10.007.
[2]
Yan CQ, Huo JW, Wang X, et al. Different Degree Centrality Changes in the Brain after Acupuncture on Contralateral or Ipsilateral point in Patients with Chronic Shoulder Pain: A Resting-State fMRI Study[J/OL]. Neural Plast, 2020 [2022-06-07]. https://pubmed.ncbi.nlm.nih.gov/32377180. DOI: 10.1155/2020/5701042.
[3]
Li J, Li YX, Luo LJ, et al. The effectiveness and safety of acupuncture for knee osteoarthritis: An overview of systematic reviews[J/OL]. Medicine (Baltimore), 2019, 98(28) [2022-06-07]. https://pubmed.ncbi.nlm.nih.gov/31305415. DOI: 10.1097/MD.0000000000016301.
[4]
Li Y. Therapeutic effect of acupuncture at Houxi point combined with cervical points on cervical spondylosis[J]. Med J Chin People's Health, 2020, 32(16): 92-94. DOI: 10.3969/j.issn.1672-0369.2020.16.038.
[5]
Ma JN, Wang SL, Xiong J. Advances of motion style acupuncture at Hou Xi point in the treatment of acute lumbar sprain[J]. J Logist Univ PAP Med Sci, 2020, 29(7): 80-84. DOI: 10.16548/j.2095-3720.2020.07.023.
[6]
Li FQ. Effect of bitouHouxi point needle acupuncture on the functional level of upper limbs and limbs in patients with cerebral infarction[J]. Glob Tradit Chin Med, 2018, 11(3): 465-467. DOI: 10.3969/j.issn.1674-1749.2018.03.043.
[7]
Gonzalez-Castillo J, Kam JWY, Hoy CW, et al. How to interpret resting-state fMRI: ask your participants[J]. J Neurosci, 2021, 41(6): 1130-1141. DOI: 10.1523/JNEUROSCI.1786-20.2020.
[8]
Sun L, Chen YY, Fang JL, et al. Correlation between blood oxygen level dependent fMRI signal and GABA content in anterior cingulate cortex after acupuncture of Hegu (LI4)[J]. Acupunct Res, 2019, 44(12): 878-883. DOI: 10.13702/j.1000-0607.190597.
[9]
Steiner AR, Rousseau-Blass F, Schroeter A,et al. Systematic Review: Anaesthetic Protocols and Management as Confounders in Rodent Blood Oxygen Level Dependent Functional Magnetic Resonance Imaging (BOLD fMRI)-Part A: Effects of Changes in Physiological Parameters[J/OL]. Front Neurosci, 2020 [2022-06-07]. https://pubmed.ncbi.nlm.nih.gov/33192261. DOI: 10.3389/fnins.2020.577119.
[10]
Tholen MG, Trautwein FM, Böckler A, et al. Functional magnetic resonance imaging (fMRI) item analysis of empathy and theory of mind[J]. Hum Brain Mapp, 2020, 41(10): 2611-2628. DOI: 10.1002/hbm.24966.
[11]
Li A, Wang YH, Zhang F,et al. Acupuncture for gender differences and similarities in cerebral activity of health volunteers: A pilot fMRI study[J/OL]. Medicine (Baltimore), 2018, 97(50)[2022-06-07]. https://pubmed.ncbi.nlm.nih.gov/30558062. DOI: 10.1097/MD.0000000000013655.
[12]
Yu SW, Lin SH, Tsai CC, et al. Acupuncture Effect and Mechanism for Treating Pain in Patients With Parkinson's Disease[J/OL]. Front Neurol, 2019 [2022-06-07]. https://pubmed.ncbi.nlm.nih.gov/31695670. DOI: 10.3389/fneur.2019.01114.
[13]
Cai RL, Shen GM, Wang H, et al. Brain functional connectivity network studies of acupuncture: a systematic review on resting-state fMRI[J]. J Integr Med, 2018, 16(1): 26-33. DOI: 10.1016/j.joim.2017.12.002.
[14]
Liu LS, Chen SQ, Zeng DH, et al. Cerebral activation effects of acupuncture at Yanglinquan (GB34) point acquired using resting-state fMRI[J]. Comput Med Imaging Graph, 2018, 67: 55-58. DOI: 10.1016/j.compmedimag.2018.04.004.
[15]
Chen SQ, Cai DC, Chen JX, et al. Altered brain regional homogeneity following contralateral acupuncture at Quchi (LI 11) and Zusanli (ST 36) in ischemic stroke patients with left hemiplegia: an fMRI study[J]. Chin J Integr Med, 2020, 26(1): 20-25. DOI: 10.1007/s11655-019-3079-6.
[16]
Zhang J, Long Y, Yang L, et al. Clinical observation on acupuncture at Houxi point combined with tender point massage in the treatment of cervical spondylopathy with cold and qi stagnation type[J]. J Pract Tradit Chin Med, 2020, 36(6): 792-793.
[17]
Liu J, Gao F, Li D, et al. Research progress of neuropathic pain mechanism after spinal cord injury[J]. Chin J Rehabil, 2020, 35(9): 488-491. DOI: 10.3870/zgkf.2020.09.010.
[18]
Yang J, Li CF, Xu CS, et al. An fMRI study on needling in Hegu (LI4) and Houxi (SI3) of adult healthy volunteers[J]. World Chin Med, 2014, 9(12): 1575-1580. DOI: 10.3969/j.issn.1673-7202.2014.12.005.
[19]
Tang HT, Wang H, Zhu B, et al. Comparative study on fMRI of the brain based on Dicang (ST 4), Hegu (LI 4) and Houxi (SI 3) on human body[J]. Chin Acupunct&Moxibustion, 2011, 31(6): 521-525. DOI: 10.13703/j.0255-2930.2011.06.015.
[20]
Powell JL, Kemp GJ, García-Finaña M. Association between language and spatial laterality and cognitive ability: an fMRI study[J]. NeuroImage, 2012, 59(2): 1818-1829. DOI: 10.1016/j.neuroimage.2011.08.040.
[21]
Zuo ZW, Qiao PG, Xing XD, et al. Study of structural asymmetry in language-related areas of the human cortex[J]. Chin J Magn Reson Imaging, 2015, 6(2): 104-107. DOI: 10.3969/j.issn.1674-8034.2015.02.005.
[22]
Glikmann-Johnston Y, Halag-Milo T, Hendler T, et al. Functional MRI (fMRI) human mapping for indicating hippocampal content-specific responsivity and laterality[J]. Neuropsychology, 2020, 34(5): 578-590. DOI: 10.1037/neu0000634.
[23]
Zhang ZX, Cui Y, Huo XC, et al. Correlation between laterality of cerebral hemorrhage in basal Ganglia and left and right handedness[J]. Chin J Gerontol, 2014, 34(20): 5646-5647. DOI: 10.3969/j.issn.1005-9202.2014.20.005.
[24]
Paszulewicz J, Wolski P, Gajdek M. Is laterality adaptive? pitfalls in disentangling the laterality-performance relationship[J]. Cortex, 2020, 125: 175-189. DOI: 10.1016/j.cortex.2019.11.019.
[25]
Verhelst H, Dhollander T, Gerrits R, et al. Fibre-specific laterality of white matter in left and right language dominant people[J/OL]. Neuroimage, 2021 [2022-06-07]. https://pubmed.ncbi.nlm.nih.gov/33524578. DOI: 10.1016/j.neuroimage.2021.117812.
[26]
Chen QS. New progresses of studies on essence of meridian-collaterals of traditional Chinese medicine[J]. Zhen Ci Yan Jiu, 2021, 46(6): 533-540. DOI: 10.13702/j.1000-0607.201045.
[27]
Liu B, Li YH. Revelation of angiosome theory in the study of meridian point structure[J]. Zhongguo Zhen Jiu, 2016, 36(12): 1279-1282. DOI: 10.13703/j.0255-2930.2016.12.015.
[28]
Hu X, Wang H, Li J, et al. A fMRI comparative study of the correlation of left and right points Houxi(SI3) with activated brain function areas[J]. Shanghai J Acupunct Moxibustion, 2015, 34(12): 1234-1238. DOI: 10.13460/j.issn.1005-0957.2015.12.1234.
[29]
Wu GJ, Chen ZQ. Progress in study on pain modulation neural pathways[J]. Acupunct Res, 2001, 26(4): 314-320. DOI: 10.3969/j.issn.1000-0607.2001.04.016
[30]
Li LL, Liu XA. Research progress of Houxi point in treating spinal pain[J]. J EmergTradit Chin Med, 2019, 28(10): 1877-1880. DOI: 10.3969/j.issn.1004-745X.2019.10.053.
[31]
Kuner R, Kuner T. Cellular circuits in the brain and their modulation in acute and chronic pain[J]. Physiol Rev, 2021, 101(1): 213-258. DOI: 10.1152/physrev.00040.2019.
[32]
Zhou HY. Functional connectivity network involved in Hegu (LI4)being effective for orofacial based on fMRI[D]. Chengdu: Chengdu University of TCM, 2014.
[33]
Qiao L, Guo MJ, Qian JJ, et al. Research advances on acupuncture analgesia[J]. Am J Chin Med, 2020, 48(2): 245-258. DOI: 10.1142/S0192415X20500135.
[34]
Lee IS, Cheon S, Park JY. Central and Peripheral Mechanism of Acupuncture Analgesia on Visceral Pain: A Systematic Review[J/OL]. Evid Based Complement Alternat Med, 2019 [2022-06-07]. https://pubmed.ncbi.nlm.nih.gov/31186654. DOI: 10.1142/S0192415X20500135.
[35]
Li XL, Cai LN, Wang F, et al. Functional magnetic resonance imaging study of brain effect mechanism of "acupuncture at Chongyangacupoint for the treatment of walking slowly and difficulty"[J]. Chin J Magn Reson Imaging, 2018, 9(11): 831-835. DOI: 10.12015/issn.1674-8034.2018.11.006.
[36]
Li ZW, Lin JS, Zhao XT, et al. Clinical study on single point acupuncture in treating pain of patients with cervical spondylotic radiculopathy[J]. Tradit Chin Med J, 2009, 8(6): 53-56. DOI: 10.3969/j.issn.1671-2749.2009.06.019.
[37]
Chi X, Ju YL, Sun ST. Study of acupuncture Zhongzhu(SJ3) Houxi(SI3) by functional MRI(fMRI)[J]. Chin Arch Tradit Chin Med, 2007, 25(4): 843-844. DOI: 10.13193/j.archtcm.2007.04.204.chix.099.
[38]
Li XL, Li BX, Wang F, et al. Research progress of acupuncture brain effect based on fMRI[J]. China Med Her, 2020, 17(21): 30-33.
[39]
Tang HT, Wang H, Xu HB, et al. FMRI study on peripheral facial paralysis patients by electroacupuncture(EA) Hegu(LI4) on the left[J]. Chin Arch Tradit Chin Med, 2010, 28(5): 964-966. DOI: 10.13193/j.archtcm.2010.05.70.tanght.033.
[40]
Yang J, Li CF, Zhang QP, et al. Preliminary analysis of brain functional imaging in patients with peripheral facial paralysis treated with acupuncture at valley point[J]. J Chang UnivTradit Chin Med, 2012, 28(4): 608-610. DOI: 10.13463/j.cnki.cczyy.2012.04.019.
[41]
Zhang SS, Wang W, Pan YQ. Clinical observation on the treatment of hand dysfunction after stroke with chicken-claw needling at Shangbaxie (Extra) and Hegu (LI 4) combined with acupuncture at Houxi (SI 3)[J]. Zhongguo Zhen Jiu, 2019, 39(3): 271-275. DOI: 10.13703/j.0255-2930.2019.03.013.
[42]
Song QM, Zhang XC, Zhang YC, et al. Analysis on combination regularities of Houxi (SI3) in ancient times of China based on latent structure model[J]. Acupunct Res, 2022, 47(5): 459-465. DOI: 10.13702/j.1000-0607.20210134.
[43]
Xu DS, Zhao S, Cui JJ, et al. A new attempt of re-mapping acupoint atlas in the rat[J]. Zhen Ci Yan Jiu, 2019, 44(1): 62-65. DOI: 10.13702/j.1000-0607.180396.
[44]
Liu SS, Wang B, Zhan SH. Study of fMRI to the resting-state pain related brain networks connectivity in migraine modulated by acupuncture[J]. Chin Imaging J IntegrTradit West Med, 2021, 19(1): 85-87, +91. DOI: 10.3969/j.issn.1672-0512.2021.01.023.
[45]
Li XL, Liu Y, Wang F, et al. Research progress of brain functional magnetic resonance imaging of acupuncture Taichong and its matching points[J]. Chin J MagnReson Imaging, 2020, 11(8): 695-698. DOI: 10.12015/issn.1674-8034.2020.08.025.
[46]
Zhang P, Yin T, Mao YK, et al. Therapeutic effects and central mechanism of acupuncture and moxibustion for treating functional dyspepsia: study protocol for an fMRI-based randomized controlled trial[J/OL]. Trials, 2022, 23(1)[2022-06-07]. https://pubmed.ncbi.nlm.nih.gov/35668441. DOI: 10.1186/s13063-022-06411-9.
[47]
Ju L, Wen Y, Yin J, et al. Metabonomic study of the effects of different acupuncture directions on therapeutic efficacy[J]. J Chromatogr B, 2016, 1009/1010: 87-95. DOI: 10.1016/j.jchromb.2015.12.006.
[48]
Zhong H, Shao XN, Hu SN, et al. Review on the research of acupuncture and moxibustion action mechanism based on metabonomics[J]. World Chin Med, 2019, 14(3): 542-547. DOI: 10.3969/j.issn.1673-7202.2019.03.006.

PREV Research progress of different analysis methods of resting state magnetic resonance imaging in vascular cognitive impairment no dementia
NEXT Research progress of MRI on myelin oligodendrocyte glycoprotein antibody disease in children
  



Tel & Fax: +8610-67113815    E-mail: editor@cjmri.cn