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Research progress of T2-FLAIR mismatch sign in predicting molecular typing of lower-grade glioma
WANG Hanwei  ZENG Linlan  CHEN Lizhao  WANG Shunan 

Cite this article as: Wang HW, Zeng LL, Chen LZ, et al. Research progress of T2-FLAIR mismatch sign in predicting molecular typing of lower-grade glioma[J]. Chin J Magn Reson Imaging, 2022, 13(9): 136-138, 143. DOI:10.12015/issn.1674-8034.2022.09.032.


[Abstract] T2-fluid attenuated inversion recovery (FLAIR) mismatch sign is an easily recognized imaging sign in conventional magnetic resonance imaging, which is characterized by homogenous hyperintensity of the glioma on T2WI and can be suppressed by FLAIR. A large number of studies have shown that this sign can effectively predict the molecular typing of lower–grade gliomas, especially for the prediction of isocitrate dehydrogenase (IDH) mutation and 1p/19q non-codeletion. T2-FLAIR mismatch sign has great potential in future clinical application due to its noninvasive and high specificity. In this paper, we review the definition of T2-FLAIR mismatch sign, pathological-image mechanism, and clinical application.
[Keywords] magnetic resonance imaging；T2-FLAIR mismatch sign；lower-grade gliomas；molecular typing

WANG Hanwei1, 2   ZENG Linlan1, 2   CHEN Lizhao3   WANG Shunan1, 2*  

1 Department of Radiology, Daping Hospital, Army Medical University, Chongqing 400042, China

2 Chongqing Clinical Research Centre of Imaging and Nuclear Medicine, Chongqing 400042, China

3 Department of Neurosurgery, Daping Hospital, Army Medical University, Chongqing 400042, China

*Wang SN, E-mail: wangshunan@tmmu.edu.cn

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 81701661); Science and Technology Planning Project of Chongqing Clinical Research Centre of Imaging and Nuclear Medicine (No. CSTC2015YFPT-gcjsyjzx0175).
Received  2021-12-26
Accepted  2022-09-06
DOI: 10.12015/issn.1674-8034.2022.09.032
Cite this article as: Wang HW, Zeng LL, Chen LZ, et al. Research progress of T2-FLAIR mismatch sign in predicting molecular typing of lower-grade glioma[J]. Chin J Magn Reson Imaging, 2022, 13(9): 136-138, 143. DOI:10.12015/issn.1674-8034.2022.09.032.

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