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• Clinical Articles •
Comparative analysis of white matter fiber changes of chronic stable schizophrenia treated with risperidone and clozapine
LIU Nian  LÜ Su  XIAO Yuan  TANG Biqiu 

Cite this article as: Liu N, Lü S, Xiao Y, et al. Comparative analysis of white matter fiber changes of chronic stable schizophrenia treated with risperidone and clozapine[J]. Chin J Magn Reson Imaging, 2022, 13(10): 79-85. DOI:10.12015/issn.1674-8034.2022.10.011.


[Abstract] Objective To compare the characteristic differences of white matter fiber between patients with chronic stable schizophrenia treated with risperidone and clozapine.Materials and Methods Magnetic resonance diffusion tensor imaging (DTI) data were collected from 27 never-treated chronic schizophrenia patients with more than 5 years illness duration, 20 patients with risperidone monotherapy, 17 patients with clozapine monotherapy for more than 5 years, and 24 healthy controls in West China Hospital of Sichuan University from January 2010 to August 2018. FSL software was used to extract the anisotropy fraction (FA) and mean diffusivity (MD) values of the four groups. Covariance analysis was used for FA and MD values between the four groups. FDR was used for multiple comparison correction. FA and MD were correlated with clinical symptom scores, drug dose, and illness duration.Results Compared with healthy control group, the never-treated group and clozapine-treated group showed decreased FA and increased MD value (P＜0.05), the risperidone-treated group showed decreased FA values of 17 fiber tracts (P＜0.05) except left uncinate tracts and double arcuate tracts (P＞0.05), while MD values had no significant difference (P＞0.05). Compared with the never-treated group, the risperidone-treated group showed significantly increased FA values of the other 18 fasciculus (P＜0.05) except the left arcuate fasciculus and right superior longitudinal fasciculus (P＞0.05), and decreased MD values involving bilateral corticospinal tract, bilateral cingulate cingulate pathway, bilateral inferior fronto-occipital tract, left anterior thalamic radiation, left cingulate cingulate pathway, left inferior longitudinal tract, left superior longitudinal tract, right uncinate tract, the splenium and the genu of the corpus callosum (P＜0.05). There were no significant differences in FA and MD between the clozapine-treated group and never-treated group (P＞0.05). Compared with the clozapine-treated group, the risperidone-treated group showed significantly increased FA values involving bilateral anterior thalamic radiation, bilateral inferior fronto-occipital fasciculus, bilateral inferior longitudinal fasciculus, left corticospinal tract, left uncinate fasciculus, right arcuate fasciculus, right cingulum-hippocampus pathway, the splenium and the genu of the corpus callosum, and significantly decreased MD values involving bilateral inferior frontal-occipital tract, bilateral uncinate fasciculus, left inferior longitudinal fasciculus and right cingulum-hippocampus pathway (P＜0.05). The severity of symptoms in the patients with chronic schizophrenia was negatively correlated with the FA value and positively correlated with the MD value (P＜0.05).Conclusions Patients with chronic schizophrenia with clozapine monotherapy showed more severe and extensive white matter microstructure defects than patients with risperidone monotherapy, suggesting that different antipsychotics had different effects in white matter characteristics.
[Keywords] schizophrenia；risperidone；clozapine；diffusion tensor imaging；anisotropy fraction；mean diffusivity；magnetic resonance imaging

LIU Nian1, 2   LÜ Su2*   XIAO Yuan2   TANG Biqiu2  

1 Department of Radiology, Affiliated Hospital of North Sichuan Medical College, Nanchong 637000, China

2 Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China

Lü S, E-mail:lusuwcums@hotmail.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82071908, 82202124); Doctoral Research Start-up Fund project of North Sichuan Medical College (No. CBY21-QD09).
Received  2022-06-07
Accepted  2022-09-27
DOI: 10.12015/issn.1674-8034.2022.10.011
Cite this article as: Liu N, Lü S, Xiao Y, et al. Comparative analysis of white matter fiber changes of chronic stable schizophrenia treated with risperidone and clozapine[J]. Chin J Magn Reson Imaging, 2022, 13(10): 79-85. DOI:10.12015/issn.1674-8034.2022.10.011.

[1]
Lui S, Zhou XJ, Sweeney JA, et al. Psychoradiology: the frontier of neuroimaging in psychiatry[J]. Radiology, 2016, 281(2): 357-372. DOI: 10.1148/radiol.2016152149.
[2]
Yang CM, Tang J, Liu NC, et al. The effects of antipsychotic treatment on the brain of patients with first-episode schizophrenia: a selective review of longitudinal MRI studies[J/OL]. Front Psychiatry, 2021 [2022-06-08]. https://doi.org/10.3389/fpsyt.2021. DOI: 10.3389/fpsyt.2021.593703.
[3]
Zhao YJ, Zhang Q, Shah C, et al. Cortical thickness abnormalities at different stages of the illness course in schizophrenia: a systematic review and meta-analysis[J]. JAMA Psychiatry, 2022, 79(6): 560-570. DOI: 10.1001/jamapsychiatry.2022.0799.
[4]
Gutman BA, van Erp TGM, Alpert K, et al. A meta-analysis of deep brain structural shape and asymmetry abnormalities in 2, 833 individuals with schizophrenia compared with 3, 929 healthy volunteers via the ENIGMA Consortium[J]. Hum Brain Mapp, 2022, 43(1): 352-372. DOI: 10.1002/hbm.25625.
[5]
Li T, Wang Q, Zhang J, et al. Brain-wide analysis of functional connectivity in first-episode and chronic stages of schizophrenia[J]. Schizophr Bull, 2017, 43(2): 436-448. DOI: 10.1093/schbul/sbw099.
[6]
Krajner F, Hadaya L, McQueen G, et al. Subcortical volume reduction and cortical thinning 3 months after switching to clozapine in treatment resistant schizophrenia[J/OL]. Schizophrenia (Heidelb), 2022 [2022-06-08]. https://doi.org/10.1038/s41537-022-00230-2. DOI: 10.1038/s41537-022-00230-2.
[7]
Xiao Y, Liao W, Long ZL, et al. Subtyping schizophrenia patients based on patterns of structural brain alterations[J]. Schizophr Bull, 2022, 48(1): 241-250. DOI: 10.1093/schbul/sbab110.
[8]
Xiao Y, Sun HQ, Shi SL, et al. White matter abnormalities in never-treated patients with long-term schizophrenia[J]. Am J Psychiatry, 2018, 175(11): 1129-1136. DOI: 10.1176/appi.ajp.2018.17121402.
[9]
Huhtaniska S, Jääskeläinen E, Hirvonen N, et al. Long-term antipsychotic use and brain changes in schizophrenia - a systematic review and meta-analysis[J/OL]. Hum Psychopharmacol, 2017 [2022-06-08]. https://doi.org/10.1002/hup.2574. DOI: 10.1002/hup.2574.
[10]
Liu N, Xiao Y, Zhang WJ, et al. Characteristics of gray matter alterations in never-treated and treated chronic schizophrenia patients[J/OL]. Transl Psychiatry, 2020 [2022-06-08]. https://doi.org/10.1038/s41398-020-0828-4. DOI: 10.1038/s41398-020-0828-4.
[11]
Yao L, Li F, Liu JK, et al. Functional brain networks in never-treated and treated long-term Ill schizophrenia patients[J]. Neuropsychopharmacology, 2019, 44(11): 1940-1947. DOI: 10.1038/s41386-019-0428-2.
[12]
Samartzis L, Dima, Fusar-Poli P, et al. White matter alterations in early stages of schizophrenia: a systematic review of diffusion tensor imaging studies[J]. J Neuroimaging, 2014, 24(2): 101-110. DOI: 10.1111/j.1552-6569.2012.00779.x.
[13]
Holleran L, Ahmed M, Anderson-Schmidt H, et al. Altered interhemispheric and temporal lobe white matter microstructural organization in severe chronic schizophrenia[J]. Neuropsychopharmacology, 2014, 39(4): 944-954. DOI: 10.1038/npp.2013.294.
[14]
Abdolalizadeh A, Ostadrahimi H, Mohajer B, et al. White matter microstructural properties associated with impaired attention in chronic schizophrenia: a multi-center study[J/OL]. Psychiatry Res Neuroimaging, 2020 [2022-06-08]. https://doi.org/10.1016/j.pscychresns.2020.111105. DOI: 10.1016/j.pscychresns.2020.111105.
[15]
Leroux E, Vandevelde A, Tréhout M, et al. Abnormalities of fronto-subcortical pathways in schizophrenia and the differential impacts of antipsychotic treatment: a DTI-based tractography study[J]. Psychiatry Res Neuroimaging, 2018, 280: 22-29. DOI: 10.1016/j.pscychresns.2018.08.008.
[16]
Cui ZX, Zhong SY, Xu PF, et al. PANDA: a pipeline toolbox for analyzing brain diffusion images[J/OL]. Front Hum Neurosci, 2013 [2022-06-08]. https://doi.org/10.3389/fnhum.2013.00042. DOI: 10.3389/fnhum.2013.00042.
[17]
de Leeuw M, Bohlken MM, Mandl RC, et al. Reduced fronto-striatal white matter integrity in schizophrenia patients and unaffected siblings: a DTI study[J/OL]. NPJ Schizophr, 2015 [2022-06-08]. https://doi.org/10.1038/npjschz.2015.1. DOI: 10.1038/npjschz.2015.1.
[18]
Luo CY, Lencer R, Hu N, et al. Characteristics of white matter structural networks in chronic schizophrenia treated with clozapine or risperidone and those never treated[J]. Int J Neuropsychopharmacol, 2020, 23(12): 799-810. DOI: 10.1093/ijnp/pyaa061.
[19]
Kahn RS, Sommer IE. The neurobiology and treatment of first-episode schizophrenia[J]. Mol Psychiatry, 2015, 20(1): 84-97. DOI: 10.1038/mp.2014.66.
[20]
Trépanier MO, Hopperton KE, Mizrahi R, et al. Postmortem evidence of cerebral inflammation in schizophrenia: a systematic review[J]. Mol Psychiatry, 2016, 21(8): 1009-1026. DOI: 10.1038/mp.2016.90.
[21]
Jiang YC, Wang YC, Huang H, et al. Antipsychotics effects on network-level reconfiguration of cortical morphometry in first-episode schizophrenia[J]. Schizophr Bull, 2022, 48(1): 231-240. DOI: 10.1093/schbul/sbab082.
[22]
He M, Fan J, Zhou RQ, et al. NLRP3/caspase-1-mediated pyroptosis of astrocytes induced by antipsychotics is inhibited by a histamine H1 receptor-selective agonist[J/OL]. Front Aging Neurosci, 2022 [2022-06-08]. https://doi.org/10.3389/fnagi.2022.847561. DOI: 10.3389/fnagi.2022.847561.
[23]
Alvarez-Herrera S, Escamilla R, Medina-Contreras O, et al. Immunoendocrine peripheral effects induced by atypical antipsychotics[J/OL]. Front Endocrinol (Lausanne), 2020 [2022-06-08]. https://doi.org/10.3389/fendo.2020.00195. DOI: 10.3389/fendo.2020.00195.
[24]
Lally J, MacCabe JH. Antipsychotic medication in schizophrenia: a review[J]. Br Med Bull, 2015, 114(1): 169-179. DOI: 10.1093/bmb/ldv017.
[25]
Guma E, Rocchetti J, Devenyi GA, et al. Regional brain volume changes following chronic antipsychotic administration are mediated by the dopamine D2 receptor[J]. Neuroimage, 2018, 176: 226-238. DOI: 10.1016/j.neuroimage.2018.04.054.
[26]
Ahmed M, Cannon DM, Scanlon C, et al. Progressive brain atrophy and cortical thinning in schizophrenia after commencing clozapine treatment[J]. Neuropsychopharmacology, 2015, 40(10): 2409-2417. DOI: 10.1038/npp.2015.90.
[27]
Tronchin G, Akudjedu TN, Ahmed M, et al. Progressive subcortical volume loss in treatment-resistant schizophrenia patients after commencing clozapine treatment[J]. Neuropsychopharmacology, 2020, 45(8): 1353-1361. DOI: 10.1038/s41386-020-0665-4.
[28]
Joo SW, Kim H, Jo YT, et al. White matter impairments in patients with schizophrenia: a multisite diffusion MRI study[J/OL]. Prog Neuropsychopharmacol Biol Psychiatry, 2021 [2022-06-08]. https://doi.org/10.1016/j.pnpbp.2021.110381. DOI: 10.1016/j.pnpbp.2021.110381.
[29]
Wei W, Yin YB, Zhang YM, et al. Structural covariance of depth-dependent intracortical myelination in the human brain and its application to drug-naïve schizophrenia: a T1w/T2w MRI study[J]. Cereb Cortex, 2022, 32(11): 2373-2384. DOI: 10.1093/cercor/bhab337.
[30]
Wei W, Zhang YM, Li YF, et al. Depth-dependent abnormal cortical myelination in first-episode treatment-naïve schizophrenia[J]. Hum Brain Mapp, 2020, 41(10): 2782-2793. DOI: 10.1002/hbm.24977.
[31]
Liu JK, Yao L, Zhang WJ, et al. Dissociation of fractional anisotropy and resting-state functional connectivity alterations in antipsychotic-naive first-episode schizophrenia[J]. Schizophr Res, 2019, 204: 230-237. DOI: 10.1016/j.schres.2018.08.005.
[32]
Cheng W, Palaniyappan L, Li ML, et al. Voxel-based, brain-wide association study of aberrant functional connectivity in schizophrenia implicates thalamocortical circuitry[J/OL]. NPJ Schizophr, 2015 [2022-06-08]. https://doi.org/10.1038/npjschz.2015.16. DOI: 10.1038/npjschz.2015.16.
[33]
Wu GW, Palaniyappan L, Zhang MQ, et al. Imbalance between prefronto-thalamic and sensorimotor-thalamic circuitries associated with working memory deficit in schizophrenia[J]. Schizophr Bull, 2022, 48(1): 251-261. DOI: 10.1093/schbul/sbab086.
[34]
Cobia D, Rich C, Smith MJ, et al. Thalamic shape abnormalities differentially relate to cognitive performance in early-onset and adult-onset schizophrenia[J/OL]. Front Psychiatry, 2022 [2022-06-08]. https://doi.org/10.3389/fpsyt.2022.803234. DOI: 10.3389/fpsyt.2022.803234.
[35]
Jung S, Kim JH, Sung G, et al. Uncinate fasciculus white matter connectivity related to impaired social perception and cross-sectional and longitudinal symptoms in patients with schizophrenia spectrum psychosis[J/OL]. Neurosci Lett, 2020 [2022-06-08]. https://doi.org/10.1016/j.neulet.2020.135144. DOI: 10.1016/j.neulet.2020.135144.

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