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• Clinical Articles •
Measurement of the diameter of retrobulbar optic nerve sheath in Chinese healthy adults by MRI and its related factors
LIU Chang  JI Haixia  TIAN Yanghua  XIE Yiju  WANG Lidan  DENG Kexue 

Cite this article as: Liu C, Ji HX, Tian YH, et al. Measurement of the diameter of retrobulbar optic nerve sheath in Chinese healthy adults by MRI and its related factors[J]. Chin J Magn Reson Imaging, 2022, 13(10): 103-107. DOI:10.12015/issn.1674-8034.2022.10.015.


[Abstract] Objective To evaluate the normal values of retrobulbar optic nerve sheath diameter (ONSD) in Chinese adults measured by MRI and analyze the potential factors affecting it.Materials and Methods The materials of healthy adults who underwent brain MRI examination for health screening between July 2017 and November 2020 were retrospective analyzed. The ONSD and eyeball transverse diameter (ETD) of each eye were measured at 3 mm behind the eye. Linear regression was used to determine the relationship between ONSD and the variables such as age, sex, height, weight, body mass index (BMI), mean arterial blood pressure (MABP), and ETD.Results A total of 413 subjects were included in the study. There were 227 males and 186 females, aged (42±12) years. The mean ONSD of 413 subjects was [4.76 (95% CI: 4.72-4.80)] mm. Upon simple linear regression analysis, we observed that the mean ONSD did vary with sex (P=0.002) and ETD (P=0.002). Further multiple linear regression analysis also showed that sex (P＜0.001) and ETD (P=0.001) were associated with ONSD. The mean ONSD for males was (4.86±0.42) mm compared with (4.63±0.40) mm for females, which meant a significant difference between the two groups (P＜0.001). We further assessed a normative value for the ONSD/ETD ratio, the mean value of which was 0.22 (95% CI: 0.21-0.22) mm.Conclusions This study established the range of MRI-based ONSD in healthy Chinese adults. Sex and ETD were the influencing factors of ONSD measurement. The difference in the ONSD value by sex suggest that separate normal reference ranges are need for men and women.
[Keywords] optic nerve sheath diameter；health；Chinese adult；intracranial pressure；magnetic resonance imaging

LIU Chang1   JI Haixia2   TIAN Yanghua2   XIE Yiju1   WANG Lidan1   DENG Kexue1*  

1 Department of Radiology, the First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei 230036, China

2 Department of Neurology, the First Affiliated Hospital of Anhui Medical University, Hefei 230032, China

Deng KX, E-mail: dengkexue-anhui@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 32071054).
Received  2022-06-08
Accepted  2022-09-28
DOI: 10.12015/issn.1674-8034.2022.10.015
Cite this article as: Liu C, Ji HX, Tian YH, et al. Measurement of the diameter of retrobulbar optic nerve sheath in Chinese healthy adults by MRI and its related factors[J]. Chin J Magn Reson Imaging, 2022, 13(10): 103-107. DOI:10.12015/issn.1674-8034.2022.10.015.

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