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• Original Articles •
Comparative study on resting functional connection of amygdala between recurrent and first-episode depression
SUN Jifei  MA Yue  GUO Chunlei  LUO Yi  GAO Shanshan  CHEN Qingyan  HONG Yang  ZHANG Guolei  FANG Jiliang 

Cite this article as: Sun JF, Ma Y, Guo CL, et al. Comparative study on resting functional connection of amygdala between recurrent and first-episode depression[J]. Chin J Magn Reson Imaging, 2022, 13(10): 144-149. DOI:10.12015/issn.1674-8034.2022.10.022.


[Abstract] Objective To explore the functional connectivity (FC) alterations in RDE by comparing the resting-state FC differences in amygdala in recurrent depressive episodes (RDE) and first depressive episode (FDE) characteristics.Materials and Methods Twenty-one patients with RDE, patients with FDE, and healthy controls (HCs) were included, and resting-state brain function MRI data were collected from the 3 groups of subjects, and clinical depression, anxiety, and redundancy scales were completed. One-way ANOVA was used to compare the differences between bilateral amygdala and whole brain FC in the 3 groups, and the results were corrected for Gaussian random fields. Time series means (FC values) of the brain regions with differences in FC between the 3 groups were extracted and the results were Bonferroni corrected (P＜0.016) for post hoc two-by-two comparisons of FC values. Finally, Pearson correlation analysis was performed between FC values and clinical scale scores for the statistically different brain regions among the 3 groups.Results (1) Compared with the FDE group, the FC of the left amygdala with the left and right anterior cingulate gyrus/left orbital part of the superior frontal gyrus was increased in the RDE group, and the FC of the right amygdala with the right precentral gyrus/right precuneus and right supplementary motor area/right middle cingulate gyrus was increased in the RDE group. Compared with the HC group, the FC of the left amygdala with the left and right anterior cingulate gyrus/left orbital part of the superior frontal gyrus was increased in the RDE group. (2) The FC values of the left amygdala and the left and right anterior cingulate/left orbital part of the superior frontal gyrus in the RDE group were positively correlated with the Rumination Response Scale (RRS) scores (r=0.460, P=0.033).Conclusions There were differences in FC between RDE and FDE in the amygdala and limbic circuits, reward circuit, somatosensory-motor areas and default mode network, and a more extensive FC alteration feature was present in RDE, which may be the reason why the neuropathological mechanism of RDE is more complex.
[Keywords] recurrent depressive episodes；first episode depression；amygdala；resting-state；magnetic resonance imaging；functional connection

SUN Jifei1   MA Yue1   GUO Chunlei1   LUO Yi1   GAO Shanshan1   CHEN Qingyan1   HONG Yang2   ZHANG Guolei2*   FANG Jiliang1*  

1 Functional Brain imaging Lab, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

2 Department of Radiology, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China

Zhang GL, E-mail: glzhang2009@126.com Fang JL, E-mail: Fangmgh@163.com

Conflicts of interest   None.

ACKNOWLEDGMENTS National Natural Science Foundation of China (No. 82174282, 81774433); National Key Research and Development Program of China (No. 2018YFC1705802); China Academy of Chinese Medical Sciences Innovation Fund (No. CI2021A03301) .
Received  2021-11-24
Accepted  2022-10-13
DOI: 10.12015/issn.1674-8034.2022.10.022
Cite this article as: Sun JF, Ma Y, Guo CL, et al. Comparative study on resting functional connection of amygdala between recurrent and first-episode depression[J]. Chin J Magn Reson Imaging, 2022, 13(10): 144-149. DOI:10.12015/issn.1674-8034.2022.10.022.

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